Comparative study of the chronic toxicity of two organotin compounds on albino rats

This study was conducted on 360 adult albino rats of both sexes to evaluatesome of the chronic toxicity of two organotin compounds [TBTO and MBTCL]. Therats were grouped into two control groups orally received the vehicles and twoother groups orally received 1/10 of oral LD50 of TBTO and MBTCL. Monthly forthree months, biochemical and histopathological investigations were done. Tenrats were taken monthly from each group to make their chromosomal patterns. As regards nephrotoxicity, both compounds produced remarkable progressivehistopathological changes with no significant increase in blood urea andcreatinine. The hepatotoxin of both compounds were nearly the same throughthe study [biochemically and histopathologically]. Also, both compounds causeprogressive histopathological changes of almost the same degree in lungs,intestine, brain and heart. Regarding the cytogenetic study, TBTO was foundto be more toxic than MBTCL. This was deduced from the very highlysignificant increase in the number of cells with structural chromosomalanomalies and the total number of structural anomalies in the TBTO treatedgroup as compared with MBTCL treated group. It can be concluded that both TBTOand MBTCL were potentially toxic to the liver, kidneys and lungs. They hadalso mild to moderate toxic effects on intestine, brain and heart. Bothcompounds were highly genotoxic to albino rats. TBTO having more genotoxicpotential. Most of the toxic effects of both compounds were progressive

Improvement of some cases of impotence from the medicolegal point of view

A detailed study on a new treatment of male impotence by using a smooth muscle relaxant drugs which is papaverine by local intracavernous injection. This treatment found to be successful in all cases of psychogenic impotence and almost all cases of organic impotence giving hope to many patients who were until recently beyond any hope of ever achieving an erection again. In light of this study a new evaluation diagnosis and judgment in many cases of impotence will emerge on the medicolegal surface and we must consider these cases with a different perspective

Vascular changes and medicolegal aspects of sudden death

A detailed histopathological study of three different arteries basilar, coronary and femoral was carried out on 30 subjects [9 females, 21 males] with age ranged from 17-55 years old who died suddenly in Sharkia governorate and were submitted to medicolegal examination at department of Forensic Medicine. 16 only out of 30 individuals [53.33%] were affected by one or more pathological changes in their different arteries [13 males and 3 females]. The pathological changes were much more common among men than women and the incidence of the lesions increases with the age until it reach the maximum above the age of 40 Y. 100%. The atheromatous changes was the most common pathological changes found in almost all affected persons and we also noticed that coronary artery was the most common affected artery in our series [13 out of 16 persons]