RESUMO
To study the frequency of bleeding and associated risk factors among patients undergoing Percutaneous Coronary Intervention [PCI]. This cross-sectional study was conducted on 500 consecutive patients, who underwent PCI at Punjab Institute of Cardiology, Lahore. Bleeding was defined according to REPLACE - 2 criteria. There were 82 females [16.4%] and 418 males [83.6%]; mean age 53.4 [ +/- 9.6 years]. Bleeding complications occurred in 6.2% [n=31] of patients; major bleed 0.8% [n= 4] and minor bleed 5.6% [n= 27]. One patient with major bleed [retroperitoneal] died in hospital. The frequency of bleeding complications was 8.5% among females and 5.7% among males [P=0.24]. Radial route was used in majority [88.6%]. The risk factors found to be significantly associated with the development of post-PCI bleeding were diabetes [OR: 6.4; P < 0.0001], hypertension [OR: 13.2; P < 0.0001], smoking [OR:8.31; P<0.0001] and BMI > 40 [OR: 6.8; P < 0.002], use of streptokinase [OR: 3.1; P < 0.0005], femoral approach [OR:4.2; P < 0.02], anaemia [OR: 44.8; P < 0.0001] and ACT >/- 350 [OR: 3.73; P < 0.0005]. In our study, female gender, procedure time >/-60 minutes, use of Glycoproteins IIb/IIIa inhibitors [GPI], and patient's age >/-50 years did not show significant association with post PCI bleeding. Major bleeding complications during Percutaneous Coronary Intervention [PCI] though occur rarely, are an important cause of patient morbidity and mortality