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1.
International Eye Science ; (12): 1012-1016, 2023.
Artigo em Chinês | WPRIM | ID: wpr-973796

RESUMO

AIM: To investigate the difference, correlation, and consistency of corneal thickness and the thinnest point position detected by Pentacam HR corneal topography map and RTVue optical coherence tomography(OCT)in patients with keratoconus.METHODS: Cross-sectional comparative study. The corneal curvature map, corneal thickness map, thinnest point position, and thinnest point thickness were detected by Pentacam HR and RTVue OCT. Paired sample t-test was used for data consistent with normal distribution, and paired sample rank sum test was used for data inconsistent with normal distribution. Spearman correlation analysis and Bland-Altman analysis were used for the correlation and consistency of the two measurement methods.RESULTS: A total of 63 patients(105 eyes)with keratoconus were included in this study, including 49 males(77.8%)and 14 females(22.2%), aged 22.24±6.19 years; among them, relevant data of Pentacam HR topographic map: Km was 47.85±4.73D and Kmax was 55.43±8.72D. In measuring central corneal thickness and the thinnest point thickness of keratoconus, the Pentacam HR was 4.70μm and 19.46μm thicker than the mean value measured by RTVue OCT(P<0.05). There was no significant difference between the horizontal and vertical coordinates of the thinnest points measured by the two devices(P>0.05). The central corneal thickness and the thinnest point thickness measured by the two devices were highly correlated, the horizontal coordinate of the thinnest point was moderately correlated, and the vertical coordinate of the thinnest point was weakly correlated. Bland-Altman analysis showed that the central corneal thickness, the thinnest point thickness, the horizontal coordinate of the thinnest point, and the vertical coordinate of the thinnest point were 95.2%(100/105)and 93.3%(98/105), 95.2%(100/105), 95.2%(100/105)respectively, which were within the 95% consistency limit, while the consistency ranges were -36.00~+26.62μm, -42.27~+3.36μm, -0.80~+0.84mm, and -1.95~+1.06mm, respectively.CONCLUSION: In keratoconus, the central corneal thickness and the thinnest point thickness measured by Pentacam HR were higher than those measured by RTVue OCT. It is not recommended that the central corneal thickness and the thinnest point thickness measured by the two instruments be interchangeable in clinical use because of the wide range of consistency between the two instruments' results. The position of the thinnest corneal point measured by the two instruments is similar and consistent, so it could be considered to replace the measured values of the two instruments in clinical use.

2.
Journal of Korean Academy of Community Health Nursing ; : 254-267, 2021.
Artigo em Inglês | WPRIM | ID: wpr-915181

RESUMO

Purpose@#The purpose of this study was to identify the effects of brain-wave biofeedback training nursing intervention (NFT) upon enhancing self-regulation response in adolescence with emotional behavior problems in school. @*Methods@#A quasi-experimental design was conducted. The participants were assigned to the experimental group (n=24) or the control group (n=24). The experimental group additionally received NFT. The NFT was conducted 10 sessions for 30 minutes per session with the band reward and inhibit training which matched their Quantitative Electroencephalography (QEEG), participant’s demand and chief complaint. Data were collected with QEEG and heart rate variability (HRV) in physiological response, self-efficacy in cognitive response, depression in emotional response, impulsivity and delay gratification in behavioral response of self-regulation. @*Results@#The general characteristics and the pre-test scores of two groups were all homogeneous. The experimental group was reported to be significantly higher in QEEG homeostasis, HRV homeostasis, self-efficacy, and delay gratification than the control group. The experimental group was reported to be significantly lower in depression and impulsivity. @*Conclusion@#The results indicate that NFT using brain cognitive neuroscience approach is effective in enhancing self-regulation response. Therefore, this nursing intervention using brain cognitive neuroscience approach can be applied as an effective self-regulation nursing intervention for adolescents with emotional behavior problems in communities for adaptive life.

3.
Korean Journal of Rehabilitation Nursing ; : 34-45, 2021.
Artigo em Coreano | WPRIM | ID: wpr-920342

RESUMO

Purpose@#This study aimed to investigate the influence of the propensity for dispositional optimism and food-related lifestyle on health promotion behaviors in middle-aged early onset stroke patients. @*Methods@#With a descriptive study design, this study covered middle-aged patients aged 40 to 65 years old who were admitted to P city general hospital after the onset of hemorrhagic or ischemic stroke. Date were collected with a questionnaire including dispositional optimism, food-related lifestyle, and health promoting behaviors. Using SPSS/MIN 23.0 program, data were analyzed with descriptive statistics, frequency, t-test, one-way ANOVA, Pearson's correlation coefficients and multiple regression. @*Results@#The dispositional optimism had a significant correlation with health promotion behavior. Positive awareness and coping with life (β=.28, p<.001) showed the greatest influence on health promotion behavior. In food-related lifestyle, health type (β=.26, p<.001), foodie type (β=.20, p=.002), and stable type (β=.14, p=.027) and occupation (β=-.14, p=.037) influenced on health promotion behavior. The explanatory power value of regression model was 46.5% and it was statistically significant (F=16.73, p<.001). @*Conclusion@#An early program may help health promotion behavior by enhancing the dispositional optimism and food-related lifestyle in middle-aged early onset stroke patients.

4.
Chinese Journal of Applied Physiology ; (6): 235-239, 2020.
Artigo em Chinês | WPRIM | ID: wpr-827811

RESUMO

To investigate the effects of exogenous NaHS on myelin basic protein (MBP) and learning and memory of hippocampal neurons in mice with spinocerebellar ataxia type 3 (SCA3) and its therapeutic significance. Twelve male normal mice were randomly selected as normal control group (NC Group), and 48 SCA3 mice were randomly selected as SCA3 model group (M Group), low dose group (NL Group, 10 μmol/kg), medium dose group (NM Group, 50μmol/kg) and high dose group (NH Group, 100 μmol/kg), 12 rats in each group. The drug treated groups were injected with NaHS intraperitoneally once a day for 4 weeks. The changes of learning and memory ability of SCA3 mice before and after the intervention of different doses of NaHS were determined by Morris water maze, the content of hydrogen sulfide (HS) in hippocampus was measured by spectrophotometry, the expression of MBP was detected by immunohistochemistry, and the morphological changes of neuron myelin sheath were observed by electron microscope. Compared with the control group, the learning and memory ability of SCA3 mice was decreased significantly (P<0.05), and the content of HS in hippocampus was decreased (P<0.05). After different doses of exogenous NaHS treatment, the learning and memory ability was improved in different degrees (P<0.05), and the contents of HS and MBP in hippocampus of SCA3 mice were also improved in different degrees (P<0.05). Exogenous NaHS may increase the contents of HS and MBP in the hippocampus of SCA3 mice, which may have a protective effect on the neurons, and then improve the learning and memory ability of SCA3 mice, and provide a new idea for the treatment of SCA3.

5.
Korean Journal of Anesthesiology ; : 151-157, 2020.
Artigo | WPRIM | ID: wpr-833974

RESUMO

Background@#BMS-470539, a recently introduced selective agonist of the melanocortin 1 receptor, is known to have anti-inflammatory properties. In this study, we investigated the effects of BMS-470539 on lipopolysaccharide (LPS)-induced inflammatory responses and delayed apoptosis with its signaling pathways in human neutrophils. @*Methods@#Isolated human neutrophils were incubated with various concentrations of BMS-470539 (1, 10, and 100 µM) in the presence or absence of LPS (100 ng/ml), and the expression of pro-inflammatory cytokines, such as tumor necrosis factor alpha, interleukin (IL)-6, and IL-1β, were assessed. The effects of BMS-470539 on the expression of mitogen-activated protein kinases (MAPKs), such as p38, extracellular-signal-regulated kinase 1/2, and c-Jun N-terminal kinase, and the expression of nuclear factor kappa B (NF-κB) in LPS-stimulated human neutrophils, were evaluated by enzyme-linked immunosorbent assay. Neutrophil apoptosis was also measured by fluorescence-activated cell sorting (annexin V/propidium iodide) in LPS-stimulated neutrophils under treatment with BMS-470539. @*Results@#BMS-470539 attenuated LPS-induced expression of pro-inflammatory cytokines, and phosphorylation of MAPKs and NF-κB. LPS stimulation reduced neutrophil apoptosis compared to the controls; however, BMS-470539 significantly inhibited the reduction of neutrophil apoptosis. @*Conclusions@#BMS-470539 can suppress the inflammatory responses of LPS-stimulated neutrophils by inhibition of MAPK pathways or NF-κB pathway, and it can also inhibit LPS-delayed neutrophil apoptosis.

6.
Chinese Medical Journal ; (24): 1654-1659, 2019.
Artigo em Inglês | WPRIM | ID: wpr-771170

RESUMO

BACKGROUND@#The coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) is termed overlap syndrome (OS). COPD and OSA both have increased risks of developing cardiovascular diseases. This study aimed to explore if patients with OS exhibited a higher prevalence of cardiovascular complications, and if patients with OS exhibited vascular endothelial dysfunction and abnormalities in the cellular immune function of T lymphocytes.@*METHODS@#Totally 25 patients with stable COPD (COPD group), 25 patients with OSA (OSA group), 25 patients with OS (OS group), and 20 healthy adults (control group) were enrolled between January 2017 and December 2017 from the Respiratory Department of Tianjin Medical University General Hospital. The clinical characteristics of the four groups were collected and the expression levels of soluble vascular cell adhesion molecule-1 (sVCAM-1), tumor necrosis factor-α (TNF-α), and T-lymphocyte subsets were detected. One-way analysis of variance, χ test and Pearson correlation were used to manage the data.@*RESULTS@#The prevalence of hypertension and coronary heart disease was significantly higher in the OS group than in the control, OSA, and COPD groups (χ = 20.69, P < 0.05 and χ = 11.03, P < 0.05, respectively). The levels of sVCAM-1 and TNF-α were significantly higher in the OS group than in other groups (F = 127.40, P < 0.05 and F = 846.77, P < 0.05, respectively). The percentage of CD4+ lymphocytes and CD4+/CD8+ were both significantly lower in the OS group than in any other group (F = 25.40, P < 0.05 and F = 75.08, P < 0.05, respectively). There were significantly negative correlations in the levels of sVCAM-1 and TNF-α with CD4+/CD8+ lymphocytes (r = -0.77, P < 0.05 and r = -0.83, P < 0.05, respectively).@*CONCLUSIONS@#The prevalence of hypertension and coronary heart disease was higher in patients with OS than in patients with either OSA or COPD alone. Patients with OS exhibited more severe vascular endothelial injury, stronger inflammatory response, and lower cellular immune function.

7.
Chinese Medical Journal ; (24): 1654-1659, 2019.
Artigo em Inglês | WPRIM | ID: wpr-802622

RESUMO

Background@#The coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) is termed overlap syndrome (OS). COPD and OSA both have increased risks of developing cardiovascular diseases. This study aimed to explore if patients with OS exhibited a higher prevalence of cardiovascular complications, and if patients with OS exhibited vascular endothelial dysfunction and abnormalities in the cellular immune function of T lymphocytes.@*Methods@#Totally 25 patients with stable COPD (COPD group), 25 patients with OSA (OSA group), 25 patients with OS (OS group), and 20 healthy adults (control group) were enrolled between January 2017 and December 2017 from the Respiratory Department of Tianjin Medical University General Hospital. The clinical characteristics of the four groups were collected and the expression levels of soluble vascular cell adhesion molecule-1 (sVCAM-1), tumor necrosis factor-α (TNF-α), and T-lymphocyte subsets were detected. One-way analysis of variance, χ2 test and Pearson correlation were used to manage the data.@*Results@#The prevalence of hypertension and coronary heart disease was significantly higher in the OS group than in the control, OSA, and COPD groups (χ2 = 20.69, P < 0.05 and χ2 = 11.03, P < 0.05, respectively). The levels of sVCAM-1 and TNF-α were significantly higher in the OS group than in other groups (F = 127.40, P < 0.05 and F = 846.77, P < 0.05, respectively). The percentage of CD4+ lymphocytes and CD4+/CD8+ were both significantly lower in the OS group than in any other group (F = 25.40, P < 0.05 and F = 75.08, P < 0.05, respectively). There were significantly negative correlations in the levels of sVCAM-1 and TNF-α with CD4+/CD8+ lymphocytes (r = –0.77, P < 0.05 and r = –0.83, P < 0.05, respectively).@*Conclusions@#The prevalence of hypertension and coronary heart disease was higher in patients with OS than in patients with either OSA or COPD alone. Patients with OS exhibited more severe vascular endothelial injury, stronger inflammatory response, and lower cellular immune function.

8.
Journal of Korean Critical Care Nursing ; (3): 58-70, 2018.
Artigo em Coreano | WPRIM | ID: wpr-788152

RESUMO

PURPOSE: This study examined the factors influencing posttraumatic and conflict management styles for nursing performance in intensive care units (ICUs).METHOD: In this study, 250 nurses from eight general hospitals in three cities participated. Structured self-report questionnaires were used to collect data on posttraumatic, conflict management styles, and nursing performance. Finally, the data were analyzed by SAS 9.3 program.RESULTS: The mean of total sum scores was 31.29, and the high risk of posttraumatic symptoms was 61.2%. It was noted that nursing performance is significantly correlated with collaboration, compromise, accommodation styles, and intrusion. Collaboration styles (β=0.39, p < .001) and hyperarousal (β=−0.22, p=.050), ICU experience below 1 year (β=−0.21, p=.027) and that of 5–10 years (β=−0.19, p=.049), and compromise style (β=0.16, p=.049) were found to be the factors influencing nursing performance with 35.9% explanatory power value of regression model.CONCLUSION: The results of the study reveal that conflict management styles, hyperarousal, and ICU experience are factors predicting the successful performance of ICUs. These findings emphasize the need of developing interventions to reduce stress symptoms and conflicts in ICUs.


Assuntos
Comportamento Cooperativo , Cuidados Críticos , Hospitais Gerais , Unidades de Terapia Intensiva , Métodos , Enfermagem , Desempenho Profissional
9.
Journal of Korean Academy of Nursing ; : 208-220, 2018.
Artigo em Coreano | WPRIM | ID: wpr-713956

RESUMO

PURPOSE: The aim of this study was to analyze the effects of neurofeedback training for reducing stress and enhancing self-regulation in late adolescence to identify the possibility of use for nursing intervention. METHODS: A nonequivalent control group pre-post quasi-experimental design was used. Participants were 78 late adolescents assigned to the experimental group (n=39) that received the neurofeedback training and the control group (n=39). Data were collected on heart rate variability (HRV) and skin conductance level (SCL) to assess stress-biomarker response. The questionnaire contained 164 items from: Positive and Negative Affect Schedule (PANAS), Symptom Checklist-90-Revised (SCL-90-R) and Self-regulatory Ability scale. The neurofeedback training was based on the general adaptation syndrome and body-mind medicine. The intervention was conducted in a total of 10 sessions for 30 minutes per session with high-beta, theta and sensory motor rhythm training on scalp at central zero. RESULTS: There were significant difference in standard deviation of normal to normal interval (p=.036) in HRV and SCL (p=.029) of stress-biomarker response between the two groups. Negative affect (p=.036) in PANAS and obsessive compulsive (p=.023) and depression (p < .001) in SCL-90-R were statistically significant. Self-regulation mode (p=.004) in self-regulation ability scale showed a significant difference between the two groups. CONCLUSION: The results indicated that the neurofeedback training is effective in stress-biomarkers, psychoemotional stress response and self-regulation. Therefore, neurofeedback training using neuroscientific approach based on brain-mind-body model can be used as an effective nursing intervention for late adolescents in clinics and communities for effective stress responses.


Assuntos
Adolescente , Humanos , Agendamento de Consultas , Depressão , Síndrome de Adaptação Geral , Frequência Cardíaca , Neurorretroalimentação , Enfermagem , Couro Cabeludo , Autocontrole , Pele , Estresse Fisiológico , Estresse Psicológico
10.
Anesthesia and Pain Medicine ; : 62-67, 2017.
Artigo em Coreano | WPRIM | ID: wpr-21261

RESUMO

The most frequent perioperative cardiovascular event is cardiac dysrhythmia, defined as an abnormality of cardiac rate, rhythm or conduction. Although the occurrence of arrhythmia during the perioperative period is not uncommon, a case of newly developed perioperative atrial flutter which spontaneously converts to atrial fibrillation is rare. We report a case of atrial flutter that developed immediately after induction of general anesthesia, in a 70-year-old male patient who previously had a normal sinus rhythm. Atrial flutter changed spontaneously to atrial fibrillation after discharge to the recovery room. Dysrhythmia was unresponsive to drug therapy, and the atrial fibrillation disappeared after electric cardioversion.


Assuntos
Idoso , Humanos , Masculino , Anestesia Geral , Arritmias Cardíacas , Fibrilação Atrial , Flutter Atrial , Tratamento Farmacológico , Cardioversão Elétrica , Período Perioperatório , Sala de Recuperação
11.
Journal of Korean Academy of Nursing ; : 305-318, 2017.
Artigo em Coreano | WPRIM | ID: wpr-164202

RESUMO

PURPOSE: The aim of this study was to identify the effects of a newly developed instructional coaching program regarding Attention Deficit Hyperactivity Disorder (ADHD) for teachers. METHODS: Seventy teachers participated in this study involving a nonequivalent control group and a pretest-posttest design. The instructional coaching program consisted of eight 60-minute sessions. The program was developed through a theoretical development program involving six steps. To evaluate the effects of the program, data were collected through self-report questionnaires including the Knowledge Scale of Attention Deficit Disorder, Attitude Scale of Primary School Teachers Experiencing Students with ADHD, Practice Scale of Educational Intervention Activity, and the Korean ADHD Rating Scale. Data were analyzed with an independent t test, a chi-square test, and an ANCOVA using SPSS WIN version 20. RESULTS: The intervention program consisted of 3 sectors, 8 subjects, and 24 content items. The experimental group showed a significant improvement in attitudes toward ADHD (F=22.83, p<.001). In addition, teacher's knowledge regarding ADHD (F=7.16, p=.010) and the implementation of instructional interventions (F=4.29, p=.043) improved. Further, teachers reported a reduction in children's ADHD-related behavior (F=4.34, p=.041). Results showed that the coaching program made a positive contribution to teaching skills and understanding of school-age children with ADHD. CONCLUSION: The instructional coaching program was well structured and significantly improved not only teachers'attitudes, knowledge, and teaching skills but also the behavior of children with ADHD in class. Therefore, the program is recommended as a means of facilitating teaching and managing children with ADHD in class.


Assuntos
Criança , Humanos , Transtorno do Deficit de Atenção com Hiperatividade , Desenvolvimento de Programas
12.
Obstetrics & Gynecology Science ; : 75-78, 2016.
Artigo em Inglês | WPRIM | ID: wpr-180137

RESUMO

Iatrogenic parasitic myomas are rare. The condition is defined by the presence of multiple smooth-muscle tumorous nodules in the peritoneal cavity. This may be attributable to seeding of myoma particles during uterine surgery. The clinical course is usually indolent. The disease is often asymptomatic and is usually discovered only incidentally. A 38-year-old woman who had undergone abdominal myomectomy 7 months prior presented with acute abdominal pain and a huge pelvic mass. We performed exploratory laparotomy. A parasitic mass 17 cm in diameter with a twisted omental pedicle was identified. En bloc excision of the mass and omentum was performed, followed by total abdominal hysterectomy. Histopathological examination of multiple sections revealed features compatible with an infarcted leiomyoma. Thus, we present a very rare case of an iatrogenic, rapidly growing parasitic myoma complicated by omental torsion (which caused the acute abdominal pain). We also offer a literature review.


Assuntos
Adulto , Feminino , Humanos , Dor Abdominal , Histerectomia , Laparotomia , Leiomioma , Mioma , Omento , Cavidade Peritoneal
13.
Journal of Korean Academy of Nursing ; : 169-182, 2015.
Artigo em Coreano | WPRIM | ID: wpr-87259

RESUMO

PURPOSE: This study was a meta-analysis designed to identify effects of Cognitive Behavioral Therapy (CBT) interventions in alleviating main symptoms of Attention Deficit Hyperactivity Disorder (ADHD) among school-aged children in Korea. METHODS: Examination of several databases including Research Information Sharing Service, Korean Studies Information Service System, Data Base Periodical Information Academic and hand-searched article references, resulted in identification of 1,298 studies done between 2000 and 2013 of which 21 met the inclusion criteria. Comprehensive Meta-Analysis version 2.0 was used to analyze effect sizes, explore possible causes of heterogeneity, and check publication bias with a funnel plot and its trim-and-fill analysis. RESULTS: Overall effect size of CBT intervention was large (g=1.08) along with each outcome of self-control (g=1.26), lack of attention (g=1.02), social skills (g=0.92), and hyperactivity (g=0.92). For heterogeneity, moderator analysis was performed, but no significant differences were found between the RCT (Randomized Controlled Trials) group and the NRCT (Non RCT) group. Also, meta-regression was performed using sample size, number of sessions, and length of session as predictors, but no statistically significant moderators were found. Finally, a funnel plot along with trim-and-fill analysis was produced to check for publication bias, but no significant bias was detected. CONCLUSION: Based on these findings, there is clear evidence that CBT intervention has significant positive effects on the main symptoms of school-aged children suffering ADHD. Further research is needed to target diverse age groups with ADHD along with more RCT studies to improve the effectiveness of the CBT intervention.


Assuntos
Criança , Humanos , Atenção , Transtorno do Deficit de Atenção com Hiperatividade/terapia , Terapia Cognitivo-Comportamental , Bases de Dados Factuais , Agitação Psicomotora , República da Coreia , Autocontrole/psicologia , Habilidades Sociais
14.
Gut and Liver ; : 214-223, 2015.
Artigo em Inglês | WPRIM | ID: wpr-136381

RESUMO

BACKGROUND/AIMS: Hematological abnormalities during hepatitis C virus (HCV) combination therapy with pegylated interferon alpha and ribavirin often necessitate dose reduction. Variants of the ITPA gene have been reported to protect against anemia during the early stages of HCV combination treatments but have also been associated with larger decreases in platelet counts. We aimed to identify the association between specific ITPA gene polymorphisms and hematological abnormalities in patients undergoing HCV combination therapy. METHODS: In this retrospective study, 175 patients treated with HCV combination therapy were enrolled at St. Martin De Porres Hospital in Taiwan between 2006 and 2012. Two single nucleotide polymorphisms (SNP) within or adjacent to the ITPA gene (rs1127354, rs6051702) were genotyped. We investigated the effect of ITPA gene variants on hematological abnormalities during the therapy. RESULTS: The ITPA rs1127354 minor variants were significantly associated with protection against anemia at week 4 (p=1.86 x 10(-6)) and with more severe decreases in platelet counts during HCV combination therapy. SNP rs6051702 was not associated with the hemoglobin decline to >3 g/dL at week 4 in our study (p=0.055). CONCLUSIONS: The ITPA SNP rs1127354 is a useful predictor of ribavirin-induced anemia in Taiwanese patients and may be related to more severe decreases in platelet counts during the early stage of HCV combination therapy.


Assuntos
Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Anemia/induzido quimicamente , Antivirais/efeitos adversos , Estudos Transversais , Quimioterapia Combinada/efeitos adversos , Doenças Hematológicas/induzido quimicamente , Hepacivirus , Hepatite C/tratamento farmacológico , Interferon-alfa/efeitos adversos , Polimorfismo de Nucleotídeo Único , Pirofosfatases/genética , Estudos Retrospectivos , Ribavirina/efeitos adversos , Taiwan , Trombocitopenia/induzido quimicamente
15.
Gut and Liver ; : 214-223, 2015.
Artigo em Inglês | WPRIM | ID: wpr-136380

RESUMO

BACKGROUND/AIMS: Hematological abnormalities during hepatitis C virus (HCV) combination therapy with pegylated interferon alpha and ribavirin often necessitate dose reduction. Variants of the ITPA gene have been reported to protect against anemia during the early stages of HCV combination treatments but have also been associated with larger decreases in platelet counts. We aimed to identify the association between specific ITPA gene polymorphisms and hematological abnormalities in patients undergoing HCV combination therapy. METHODS: In this retrospective study, 175 patients treated with HCV combination therapy were enrolled at St. Martin De Porres Hospital in Taiwan between 2006 and 2012. Two single nucleotide polymorphisms (SNP) within or adjacent to the ITPA gene (rs1127354, rs6051702) were genotyped. We investigated the effect of ITPA gene variants on hematological abnormalities during the therapy. RESULTS: The ITPA rs1127354 minor variants were significantly associated with protection against anemia at week 4 (p=1.86 x 10(-6)) and with more severe decreases in platelet counts during HCV combination therapy. SNP rs6051702 was not associated with the hemoglobin decline to >3 g/dL at week 4 in our study (p=0.055). CONCLUSIONS: The ITPA SNP rs1127354 is a useful predictor of ribavirin-induced anemia in Taiwanese patients and may be related to more severe decreases in platelet counts during the early stage of HCV combination therapy.


Assuntos
Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Anemia/induzido quimicamente , Antivirais/efeitos adversos , Estudos Transversais , Quimioterapia Combinada/efeitos adversos , Doenças Hematológicas/induzido quimicamente , Hepacivirus , Hepatite C/tratamento farmacológico , Interferon-alfa/efeitos adversos , Polimorfismo de Nucleotídeo Único , Pirofosfatases/genética , Estudos Retrospectivos , Ribavirina/efeitos adversos , Taiwan , Trombocitopenia/induzido quimicamente
16.
Journal of Korean Academic Society of Nursing Education ; : 382-391, 2014.
Artigo em Coreano | WPRIM | ID: wpr-150525

RESUMO

PURPOSE: The purpose of this study was to identify the predictors influencing on educational intervention for Attention Deficit Hyperactivity Disorder (ADHD) after analyzing the relationship among teachers' internal-external locus of control, leadership type and educational intervention for ADHD. METHODS: A cross sectional study design was conducted with 255 teachers in three schools located in D, K and Y city. The data were analyzed by t-test, one-way ANOVA, Pearson correlation coefficients and multiple regression using SPSS 20.0. RESULTS: Internal locus of control showed significantly positive correlations with educational intervention for ADHD. Efficient leadership type, harmony-oriented leadership type showed significant differences in inefficient leadership type on educational intervention for ADHD. Significant factors of the educational intervention were efficient leadership type, harmony-oriented leadership type, task-oriented leadership type and internal locus of control that were explained by 20.0% (F=12.5, p<.001) of educational intervention for ADHD. CONCLUSION: Based on the findings of this study, it is necessary to have teacher's efficient leadership type focused on ADHD symptoms. Teachers need to enhance their positive domain of internal-external locus of control towards students with ADHD to increase the effectiveness of their educational interventions for ADHD.


Assuntos
Humanos , Transtorno do Deficit de Atenção com Hiperatividade , Educação , Controle Interno-Externo , Liderança
17.
Journal of Korean Academy of Nursing ; : 552-562, 2014.
Artigo em Coreano | WPRIM | ID: wpr-202155

RESUMO

PURPOSE: This study was done to identify the patterns and significant predictors influencing hospitalization of Korean men for alcohol use disorder. METHODS: A descriptive study design was utilized. Data were collected using self-report questionnaires from 143 inpatients who met the DSM-5 alcohol use disorder criteria and were receiving treatment and 157 social drinkers living in the community. The questionnaires included Alcohol Use Disorders Identification Test (AUDIT), Alcohol Problems, Alcohol Expectancy Questionnaire (AEQ), Life Position, and The Korean version of the Children of Alcoholics Screening Test (CAST-K). Data were analyzed using descriptive statistics, t-test, chi2-test, F-test, Pearson correlation coefficients, and logistic regression with forward stepwise. RESULTS: AUDIT had significant correlations with alcohol problems, alcohol expectancy, and parents' alcoholism. In logistic regression, factors significantly affecting hospitalization were divorced (OR=4.18, 95% CI: 1.28-13.71), graduation from elementary school (OR=28.50, 95% CI: 8.07-100.69), middle school (OR=6.66, 95% CI: 2.21-20.09), high school (OR=6.31, 95% CI: 2.59-15.36), drinking alone (OR=9.07, 95% CI: 1.78-46.17), family history of alcoholism (OR=2.41, 95% CI: 1.11-5.25), interpersonal relationship problems (OR=1.28, 95% CI:1.17-1.41), and sexual enhancement of alcohol expectancy (OR=0.83, 95% CI: 0.72-0.94), which accounted for 53% of the variance. CONCLUSION: Results suggest that interpersonal relationship programs and customized cognitive programs for social drinkers in the community are needed to decreased alcohol related hospitalization in Korean men.


Assuntos
Adulto , Idoso , Humanos , Masculino , Pessoa de Meia-Idade , Transtornos Relacionados ao Uso de Álcool/diagnóstico , Povo Asiático , Divórcio , Relações Familiares , Hospitalização , Relações Interpessoais , Modelos Logísticos , Razão de Chances , Valor Preditivo dos Testes , Inquéritos e Questionários , República da Coreia
18.
Journal of Korean Academy of Psychiatric and Mental Health Nursing ; : 45-55, 2013.
Artigo em Coreano | WPRIM | ID: wpr-153819

RESUMO

PURPOSE: The purpose of this study was to identify how empathy mediates the relationship between teachers' knowledge of Attention Deficit Hyperactivity Disorder (ADHD) and educational interventions. METHODS: A survey for structural equation modeling was conducted with 334 teachers from 61 schools in D and Y cities in Korea. Data were collected from April 2012 to July 2012 through self-report questionnaires using standardized instruments. The data were analyzed using SPSS Win 20 and AMOS 20, and Sobel tests were conducted to determine the significance of mediation and Bootstrapping tests to construct confidence intervals. RESULTS: Teachers' empathy provided complete mediation between teachers' knowledge and educational interventions in classrooms. Results showed that empathy contributes positively to educational interventions in ADHD by increasing understanding of children with ADHD and the situation. CONCLUSION: Based on the findings of this study, teachers need to enhance their empathy towards students with ADHD to increase the effectiveness of their educational interventions for ADHD. These results suggest the importance of focusing on increasing teachers' empathy in the classroom in order to provider better education interventions for children with ADHD.


Assuntos
Criança , Humanos , Transtorno do Deficit de Atenção com Hiperatividade , Empatia , Coreia (Geográfico) , Negociação , Inquéritos e Questionários
19.
Journal of Korean Academy of Psychiatric and Mental Health Nursing ; : 147-158, 2013.
Artigo em Coreano | WPRIM | ID: wpr-101049

RESUMO

PURPOSE: The purpose of this study was to identify predictors influencing adjustment during army life after analyzing the relationship among relational self, community attitudes toward the mentally ill (CAMI), and adjustment during army life in Korea. METHODS: A cross sectional study design was conducted with 230 soldiers from two military units located in Y and B cities. Data were analyzed using t-test, one-way ANOVA, Pearson correlation coefficients, and multiple regression with SPSS/WIN 18.0. RESULTS: Empathy-care showed significantly positive correlations with adjustment during army life. Avoidance of relationships showed significantly negative correlations with adjustment. Negative concepts in CAMI, such as authoritarianism and social restrictiveness, became were getting more negative. Positive concepts in CAMI, such as benevolence and community mental health ideology, were lacking. Significant factors were empathy-care, authoritarianism, overdependence on relations, and social restrictiveness which explained 30.1% (F=8.55, p<.001) of adjustment during army life. CONCLUSION: To improve military adjustment for soldiers, it is necessary to reduce misunderstandings of people with mentally illness as well as to make efforts towards systematic interpersonal relationship interventions for positive evaluation of self and others to enhance the mental health of soldiers.


Assuntos
Humanos , Autoritarismo , Beneficência , Saúde Mental , Pessoas Mentalmente Doentes , Militares , Psicologia do Self , Ajustamento Social
20.
Journal of Korean Academy of Psychiatric and Mental Health Nursing ; : 11-20, 2012.
Artigo em Coreano | WPRIM | ID: wpr-34392

RESUMO

PURPOSE: This study was done to identify predictive factors influencing suicide probability in Korean adolescents. METHODS: Participants in the study were 575 adolescents from 17 schools with quota sampling by each region in D city. The data were collected from October to November, 2010 using self-report questionnaires about interpersonal relationships and suicide probability (SPS) and analyzed using descriptive statistics, one-way ANOVA with Scheffe of Post Hoc, Pearson's correlation coefficients, and stepwise multiple regression analysis with SPSS/WIN 16.0 program. RESULTS: Suicide probability showed a significantly negative correlation for interpersonal relations with parents, friends and teachers. Interpersonal relationship with parents (p<.001) explained 32% of suicide probability, compared to relationships with peers or teachers, which together was accounted for 46% of the variance. CONCLUSION: The findings suggest that interpersonal relationships with parents should be considered when adolescents suffer from suicidal thinking. Various effective strategies to improve relationships with parents are important to reduce suicide in adolescents.


Assuntos
Adolescente , Humanos , Amigos , Relações Interpessoais , Pais , Inquéritos e Questionários , Suicídio , Pensamento
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