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1.
Asian Pac J Allergy Immunol ; 2003 Dec; 21(4): 205-10
Artigo em Inglês | IMSEAR | ID: sea-37012

RESUMO

Chemokine receptor expression has been shown to be associated with the differentiation of T helper cells. The CCR3, CXCR4 and CCR5 expression on circulating T cells were studied in 30 house dust mite sensitive-patients with allergic diseases and in another 30 healthy controls. The expression was analyzed in CD4, CD8 and double negative (DN) T cells by triple fluorescence staining. In addition, intracellular cytokine staining was performed in the CCR3+ CD4+ T cells. Increased circulating portions of CCR3+ CD4+ T cells and CCR3+ DN T cells were found in these patients (p < 0.01). There was no statistically significant difference in the expression of CXCR4 and CCR5 on T cells. The follow-up data of the patients did not show a statistically significant change in the CCR3 expression. IL-4 was expressed within CCR3+ CD4+ T cells upon activation. The IL-4 secreting CCR3+ type 2 T helper cells may play a pathogenetic role in immune responses of house dust mite-sensitive Chinese patients with allergic diseases.


Assuntos
Adolescente , Adulto , Animais , Linfócitos T CD4-Positivos/imunologia , Poeira/imunologia , Feminino , Humanos , Hipersensibilidade/imunologia , Interleucina-4/metabolismo , Masculino , Pessoa de Meia-Idade , Ácaros/imunologia , Receptores CCR3 , Receptores de Quimiocinas/metabolismo , Taiwan , Células Th2/imunologia
2.
Asian Pac J Allergy Immunol ; 2002 Dec; 20(4): 223-7
Artigo em Inglês | IMSEAR | ID: sea-36891

RESUMO

The anti-C1q antibody has been shown to be associated with lupus patients with renal involvement. We conducted a study to determine the relationship between the serum anti-C1q titer and the renal deposition of C1q. The serum anti-C1q was measured in 26 healthy controls and 47 systemic lupus erythematosus (SLE) patients who were divided into 2 groups as non-nephritis and nephritis SLE. We analyzed the relationship between the anti-C1q titers and SLE, renal C1q staining and the WHO classification for lupus nephritis. The result revealed that the serum anti-C1q was present in 50.8% of the SLE patients, that its levels in those with renal involvement were significantly higher than in the normal control group (61.540 +/- 87.720 U/ml vs 15.750 +/- 2.530 U/ml, p = 0.005). Besides, the serum anti-C1q levels were higher in the patients with lupus nephritis with C1q deposition in the kidney tissue (66.038 +/- 91.141 U/ml vs 16.652 +/- 3.097 U/ml, p < 0.01). There seems to be evidence supporting that the autoantibody anti-C1q might play a pathogenic role in lupus nephritis.


Assuntos
Adulto , Autoanticorpos/sangue , Complemento C1q/imunologia , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Rim/imunologia , Lúpus Eritematoso Sistêmico/sangue , Nefrite Lúpica/sangue , Masculino
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