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1.
Malaysian Orthopaedic Journal ; : 54-56, 2019.
Artigo em Inglês | WPRIM | ID: wpr-777681

RESUMO

@#Pseudogout and gout are common types of inflammatory joint disease in the elderly. However, the existence of both in a single joint in a patient is relatively rare. This case report describes an interesting case of a 42-year old man who presented with simultaneous gout and pseudogout in the knee joint, diagnosed via polarised light microscopy. There was no radiographic evidence of pseudogout. This case report serves to illustrate the need to actively exclude concomitant pseudogout, especially in patients suffering from recurrent attacks of gout.

2.
Braz. j. med. biol. res ; 50(11): e6353, 2017. tab, graf
Artigo em Inglês | LILACS | ID: biblio-888951

RESUMO

This study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study factors on drug absorption, including drug mass concentration, absorption site, and the different types and concentrations of absorption inhibitors. Within the scope of experimental concentrations, three curcumin constituents were absorbed in rat small intestines through the active transport mechanism.


Assuntos
Animais , Masculino , Feminino , Adjuvantes Farmacêuticos/farmacologia , Curcumina/análogos & derivados , Curcumina/farmacocinética , Inibidores Enzimáticos/farmacocinética , Absorção Intestinal , Intestino Delgado/metabolismo , Valores de Referência , Fatores de Tempo , Desacopladores/farmacologia , Verapamil/farmacologia , Probenecid/farmacologia , Reprodutibilidade dos Testes , Cromatografia Líquida de Alta Pressão/métodos , Ratos Sprague-Dawley , Transportadores de Cassetes de Ligação de ATP/antagonistas & inibidores , 2,4-Dinitrofenol/farmacocinética , Curcumina/química , Proteínas Associadas à Resistência a Múltiplos Medicamentos/análise , Proteínas Associadas à Resistência a Múltiplos Medicamentos/antagonistas & inibidores , Emulsões , Imagem de Perfusão/métodos , Absorção Intestinal/efeitos dos fármacos , Intestino Delgado/efeitos dos fármacos
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