RESUMO
Objective: To find out the preventive effect of flaxseed oil on the hepatic damage produced by the Lipofundin, a soya-bean based lipid emulsion used in parenteral therapies
Study Design: Experimental study
Place and Duration of Study: The study was carried out at the University of Health Sciences, Lahore for a period of one year, from Jan 2015 to Dec 2015
Material and Methods: Experimental study has been performed to study the effect of flaxseed oil on the lipofundin induced hepatotoxicity. Thirty-two male adult albino rats were obtained from animal house of University of Health Sciences, Lahore and divided into four equal groups. Group A [control group] was given flaxseed oil 3ml/kg intraperitonially daily for 10 days and sacrificed on day 11. Group B was given Lipofundin 2ml/kg intravenously daily for 10 days and sacrificed on day 11. Group C was given Lipofundin 2ml/kg intravenously daily for 10 days and sacrificed on day 21. Group D was given Lipofundin 2ml/kg intravenously for 10 days followed by Flaxseed oil 3ml/kg intraperitonially for 10 days and sacrificed on day 21
Results: Flaxseed oil was observed to restore the hepatic tissue damage caused by the lipofundin administration
Conclusion: Flaxseed oil has an ameliorative effect on the hepatic tissue damage caused by the Lipofundin.Hence its use may help prevent hepatic tissue damage caused by lipofundin used in parenteral therapies
RESUMO
For differentiation and maintenance of epithelial cells in vitro and vivo wider the influence ofretinoic acid treatment, skin seems to be a major target organ for both the normal and patholo-gical states. The current study was conducted to evaluate the effects ofretinoic acid on fetal skin if given to albino mice during pregnancy. Twelve pregnant albino mice were divided into two groups of 6 each; the experimental group was given 60 mg/kg/day ofretinoic acid [RA] dissolved in o.iml of olive oil orally on 7, 8 and 9 day of gestation. Fetuses were delivered and dissected on 18[th] day of gestation; skin samples were removed and processed for microscopic study. Histological examination of fetal skin in RA treated group showed increased keratinocyte proliferation resulting in increased number of epidermal cell layers and increased epidermal thickness. It also inhibited the development of hair follicles which are seen in the form of rudimentary buds in the dermis. So its usage during pregnancy should be warranted. Given the essential role of retinoids in epidermal differentiation and their effectiveness in the treatment of several skin orders it is important to see its histological effects on skin