RESUMO
Parathyroid carcinoma is a rare endocrine malignancy accounting for less than 1% of all cases of hyperparathyroidism. We present a case of a middle-aged woman who was undiagnosed for 3 years before presenting with renal stones and advanced musculoskeletal disease. Investigations revealed primary hyperparathyroidism. Focused cervical exploration and left inferior parathyroidectomy was carried out based on the pre-operative localization studies. Parathyroid carcinoma was diagnosed on histopathology postoperatively. Subsequent en bloc resection was not performed and the patient is being monitored with serial parathyroid hormone levels which have not shown any increase in 6 months of follow-up. Only two previous cases of parathyroid carcinoma have been reported from Pakistan
RESUMO
To find the association of tumor size with grade of tumor and its extra capsular extension. A review of record of all renal biopsies performed at pathology department King Edward Medical University over a period of two years was done. It was found that large sized tumors tend to have a higher grade and this correlation was found to be statistically significant [P=0.02]. A significant correlation was also seen between the size of tumor and extra capsular extension [P=0.001]. It was concluded patients presenting with larger renal tumors, who subsequently underwent nephrectomy and histopathological analysis were diagnosed with a higher grade. This relation implies that these patients with larger tumors will in turn have poorer prognosis