Endogenous fatty acid profile in android abese women [nondiabetic-diabetic]: its relationship to lipoprotein metabolism

Obese premenopausal women with high waist-hip ratio [WHR] of the android pattern displayed an increased risk of metabolic disorderes in comparison with age-matched normal control women as evidenced by their atherogenic plasma lipid and lipoproteins profiles together with high plasma insulin and glucose levels, these latter two point to a state of insulin resistance. When compared with their normal controls the chromatographic study of the fasting plasma fatty acids of the obese android females [both the non diabetics and diabetics] showed a rise in the saturated fatty acids C11:0, C12:0, C14:0 and C20:0 and the monounsaturated fatty acid C18:1. Meanwhile the polyunsaturated fatty acids were significantly reduced specially linolenic acid [C18:3]. These obese android females had got near normal concentrations for precursor satiric acid C18:0, the rise of the lower unsaturated individuals more than the higher unsturations of this acid was not met within the normal controls. This rise of the lower unsaturations of C18:0 seems to be the expense of the higher ones i.e. A shift to the left is prominent in these patients. Failure to achieve-higher unsaturations was attributed either to a deficient or defective desaturase enzyme which might have been aggravated by the accompanying insulin resistance state of those patients. The combination of elevated plasma saturared fatty acids and the absence of higher unsaturated fatty acids underlie the pathological metabolic complications that characterize android obesity. Correlation studies between the individual fatty acids and the different atherogenic parameters of the different plasma lipoproteins could reveal that in android obese patients there was an inverse correlation between the atherogenic index [VLDL-C+LDL-C/HDL-C] and the different protective fatty acid rations. These correlations were more strong and pronounced in the diabetic androids

Serum prolactin level in individuals occupationally exposed to organic dust

In the present work 80 wheat workers and 20 unexposed volunteers were studied. Clinical examination together with measuring the level of serum IgG, IgG, and prolactin were done. This had demonstrated that exposed workers may get sensitized to antigens in the wheat dust and give rise to allergic manifestations including respiratory problems. It was found that the level of serum IgE and prolactin were significantly increased in the exposed group as a whole when compared with the controls [P <0.01 and <0.001]. The atopic exposed individuals showed a significantly increased serum prolactin and IgE as well as when compared with the non-atopic workers [P = 0.05 and <0.001]. There was also a significant positive correlation between the serum prolactin level and the IgE level in the whole exposed group but a weak +ve correlation in the atopic sub-group [r = 0.368 and r = 0.223]. In the asthmatic sub-group there was a -ve insignificant correlation between the prolactin and IgE levels [r = 0.178]. This proved that exposure more than the atopic trait is behind the increased prolactin level. The mechanism of increased prolactin level is that IgE-mast cell interaction leads to histamine release which is a potent prolactin stimulant. The lack of correlation between the level of prolactin and IgE in asthmatics was explained