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Objective:To evaluate the efficacy and safety of cognitive rehabilitation in the treatment of cognitive dysfunction caused by radiation-induced encephalopathy.Methods:A total of 63 patients with radiation-induced cognitive impairment were divided into treatment group (cognitive rehabilitation combined with conventional therapy) and control group (conventional treatment alone) for 12 weeks. The cognitive function was assessed according to Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) before and after 12 weeks treatment.Results:After 12 weeks treatment, the patients in treatment group demonstrated significant improvement in cognitive function. In treatment group, the scores of patients after cognitive rehabilitation in MoCA and MMSE were obviously higher than the control group( t=5.20, 3.18, P<0.01). The scores in the visual space, naming, attention, abstract thinking, delayed memories and orientating also had improved, with statistically significant difference( t=-3.51, -3.09, -3.18, -2.57, -3.52, -3.39, P<0.05). Conclusions:Cognitive rehabilitation combined with conventional treatment was signally effective in the therapy of cognitive dysfunction caused by radiation-induced encephalopathy.
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@#［18F］6-fluoro-3, 4-dihydroxy-L-phenylalanine(［18F］F-DOPA)has been used as a radiotracer for Parkinson′s disease over 30 years. The previously reported electrophilic synthesis method has low radiochemical yield(RCY), low specific activity(SA)and other defects. Recent reported nucleophilic synthesis of ［18F］F-DOPA could overcome the disadvantages. In this paper, the nucleophilic synthetic methods for ［18F］F-DOPA are reviewed.
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A series of triazole derivatives were designed and synthesized based on a natural product cembrane separated from Croton laevigatus Vahl which showed potential antitumor activity against HeLa cells.Twelve novel compounds were synthesized and their structures were characterized by 1H NMR, 13C NMR and HRMS.Their cytotoxicities in vitro were evaluated for HeLa,K562 and K562/A02 cells by MTT assay.The results showed that some cembrane derivatives possessed antitumor activities.Substituted triazole connected to cembrane derivatives exhibited potent activity toward drug-resistant K562/A02 cells.
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Objective The objectives of this study were to investigate the relationship between DKK1 protein expression and lymph node invasion,and prognosis in patients with intrahepatic cholangiocarcinoma.Methods From January 2005 to December 2012,78 patients with intrahepatic cholangiocarcinoma were treated with endoscopic resection.Tissue microarray of intrahepatic cholangiocarcinoma and adjacent tissues were done and biochemical indexes were measured before operation.The patients were recruited every 3 months after operation.The Kaplan-Meier method was used to analyze the recurrence-free survival curve and the overall survival curve.The Cox proportional hazards regression model was used to analyze the multivariate analysis and to determine the factors that affect the disease-free survival(RFS)and overall survival(OS).Results There were significant differences in the expression of GGT,hepatic portal lymph node invasion,Child-Pugh grade,MMP9 and DKK1 protein in the negative and positive expression of intrahepatic cholangiocarcinoma(P ＜ 0.05).The positive expression rate of DKK1 protein in intrahepatic cholangiocarcinoma was 35.90％ (28/78),and the positive expression rate of DKK1 protein in hilar cholangiocarcinoma was 14.10％ (11/78).RFS and OS in 78 cases of intrahepatic cholangiocarcinoma were 51.28％ (40/78) and 50.00％ (38/78),41.03 ％ (32/78) and 38.46％ (30/ 78),25.64％ (20/78) and 23.08％ (18/78) after surgery for 1,3 and 5 years,respectively.The results from univariate and multivariate analysis showed that GGT,CA19-9,CEA,tumor size,DKK1 and hilar lymph node invasion were the prognostic factors of OS in patients with intrahepatic cholangiocarcinoma.CEA,tumor size,DKK1 and hilar lymph node involvement were prognostic factors for RFS in patients with intrahepatic cholangiocarcinoma.DKK1 protein expression positive and negative OS curve or RFS curve showed that 5 years after intrahepatic cholangiocarcinoma patients DKK1 protein expression positive and negative OS were 28.20％ and 20.51％;RFS were 24.36％ and 21.79％.Conclusion The expression of DKK1 protein is closely related to lymph node invasion in patients with intrahepatic cholangiocarcinoma.The expression of DKK1 protein is the prognostic factor of OS and RFS in patients with intrahepatic cholangiocarcinoma.
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Objective To study the internal reliability and construct validity of Clinical Memory Scale in patients with Parkinson's dis-ease (PD). Methods 155 PD patients were assessed with Clinical Memory Scale. Results Cronbach'sαof Clinical Memory Scale was 0.772, while split-half reliability coefficient was 0.770. One factor had been extracted with factor analysis, which explained 53.18%of variance, and loaded 5 items. Conclusion Clinical Memory Scale is available for PD patients with acceptable internal reliability and construct validity.
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@# Objective To study the characteristic of memory impairment and its related factors in patients with Parkinson's disease (PD). Methods 155 PD patients were assigned to 4 age groups. Clinical memory scale, Hamilton Rating Scale for Depression (HAMD) and Hamilton Rating Scale for Anxiety (HAMA) were used to assess them. Results The memory quotient (MQ) of PD patients were significantly lower than the norm (P<0.01). The scores of associational learning, direct memory, picture recall and portrait association in each age groups were lower than norm (P<0.05), but nonsense figure recognition (P>0.05). The MQ of PD patients was significantly related with education and depression or anxiety (P<0.01), and was not correlated with age, gender and course of disease (P>0.05). Conclusion The MQ of PD patients are lower especially in associational learning, direct memory, picture recall and portrait association. The MQ of PD patients is correlated with education and depression or anxiety significantly.