Relationship between Homocysteine Levels in Patients with Acute Ischemic Stroke and Discharged Outcome / 现代检验医学杂志

Objective To investigate the relationship between plasma homocysteine on admission and the outcome at discharge of acute ischemic stroke.Methods A non-concurrent cohort study was performed and a total of 1 3 1 9 patients with acute is-chemic stroke were continuously included in this study.According to tertile range of plasma homocysteine,patients were di-vided into three group.Logistic regression analysis was used to assess the independent association between plasma homocys-teine on admission and poor outcome at discharge of acute ischemic stroke.Results The difference of plasma homocysteine on admission between the poor outcome and those with good outcome had statistical significance (P<0.000 1).Without the adj ustment of multiple factors,when comparing to the first group,the second and third tertile seemed to have a tendency of increasing the risk of poor outcome at discharge,the OR (95%CI)was 2.111 (1.297~3.437,P<0.05),2.113 (1.361~3.279,P<0.05).After adjustment for multivariate,the second and third tertile also seemed to have a tendency of increasing the risk of poor outcome at discharge,the OR (95%CI)was 1.876 (1.160~3.036,P<0.05),2.396 (1.414~4.062,P<0.05).Conclusion The current study indicated that higher plasma homocysteine level was an independent risk factor for poor outcome at discharge in ischemic stroke patients.It would increase the risk of the outcome at discharge in patients with acute ischemic stroke,and suggests that there is a dose-response relationship between plasma homocysteine level on admis-sion and the poor outcome at discharge.

Relationship between Uric Acid Levels in Patients with Acute Ischemic Stroke and Discharged Outcome / 现代检验医学杂志

Objective To examine the association between uric acid (UA)levels of patients with acute ischemic stroke at ad-mission and discharged outcome.Methods The acute ischemic stroke patients of Xinganmeng People’s Hospital in Inner Mongolia,from June 1,2009 to May 31,2012 were continuity included in the present study,the included analysis sample size were 3 440 cases.Poor discharged outcome was defined as the occurrence of disability or death.With reference to the Modi-fied Rankin's Scale (MRs)Stroke Scale,Scores were recorded in the questionnaires,score of 3 or more (MRs≥3)was de-fined as disability.The patients were all grouped by P20,P60,P90 of UA,binary logistic regression were used in studying of risk factors,calculated the odds ratios (Odds ratio,OR)and 95% confidence interval (95% Confident interval,95%CI).All tests were two-sided test and a significance level of 0.05.Results A total of 359 people occurred poor outcomes in the stud-y,accounting for 10.44%.Univariate logistic regression analysis of poor outcome occurred showed that relative to the lowest group(P20,UA≤222.6 mmol/L),the second and third group (UA:222.7 ~ 310.9 mmol/L and 311.0~419.7 mmol/L) OR (95% CI)were:0.70(0.53~0.91)(P <0.05)and 0.66(0.49~0.88)(P <0.05).After adjusted age,body tempera-ture,high blood pressure,hyperglycemia,history of stroke,high triglycerides,high LDL-C and smoking,relative to the low-est level group,the second and third group occurred poor outcoming OR (95% CI)were:0.70(0.53~0.93)(P <0.05)and 0.66(0.48~0.90)(P <0.05).Conclusion Higher levels of uric acid levels in patients with acute ischemic stroke may inde-pendently related with occurred poor discharged outcome.

Outcomes and correlated factors in patients with impaired fasting glucose: a ten-year follow-up analysis / 中华流行病学杂志

<p><b>OBJECTIVE</b>To investigate the outcomes and relative risk factors in subjects with impaired fasting glucose in Inner Mongolia, China.</p><p><b>METHOD</b>A total number of 32 villages in Kezuohou Banner and Naiman areas in Inner Mongolia were selected as the baseline surveys study fields from 2002 to 2003. Patients with IFG (5.6 mmol/L≤FPG<7.0 mmol/L) but without history of diabetes were selected as the study subjects. A follow-up study was conducted in 2013. Multinomial logistic regression analysis was used to evaluate the correlated factors.</p><p><b>RESULTS</b>There were 384 patients with IFG recruited in the study. Out of them, 150 (39.1%) progressed to normoglycaemia, 174 (45.3%) remained as IFG, and 60 (15.6%) developed into type 2 diabetes mellitus. Through adjustment multivariately, patients that returning to the status of normoglycaemia were significantly associated under the function of TG (OR = 0.692, 95%CI:0.502-0.952, P < 0.05)and those developed to diabetes were significantly associated with factors as age(OR = 1.052, 95%CI:1.014-1.090, P < 0.05) or obesity (OR = 2.924, 95% CI:1.353-6.320, P < 0.05).</p><p><b>CONCLUSION</b>15.6% of the IFG patients developed diabetes mellitus among the Inner Mongolian population. Elevated TG was an inhibition factor for patients returning to normoglycaemia while both age and abdominal obesity were risk factors for the development of diabetes in the Inner Mongolian population.</p>

0utcomes and correlated factors in patients with impaired fasting glucose: a ten-year follow-up analysis / 中华流行病学杂志

Objective To investigate the outcomes and relative risk factors in subjects with impaired fasting glucose in Inner Mongolia,China.Method A total number of 32 villages in Kezuohou Banner and Naiman areas in Inner Mongolia were selected as the baseline surveys study fields from 2002 to 2003.Patients with IFG(5.6 mmol/L≤FPG＜7.0 mmol/L) but without history of diabetes were selected as the study subjects.A follow-up study was conducted in 2013.Multinomial logistic regression analysis was used to evaluate the correlated factors.Results There were 384 patients with IFG recruited in the study.Out of them,150 (39.1％) progressed to normoglycaemia,174 (45.3％) remained as IFG,and 60 (15.6％) developed into type 2 diabetes mellitus.Through adjustment multivariately,patients that returning to the status of normoglycaemia were significantly associated under the function of TG (OR=0.692,95％CI:0.502-0.952,P＜0.05) and those developed to diabetes were significantly associated with factors as age (OR=1.052,95％CI:1.014-1.090,P＜ 0.05) or obesity (OR=2.924,95％ CI:1.353-6.320,P＜0.05).Conclusion 15.6％ of the IFG patients developed diabetes mellitus among the Inner Mongolian population.Elevated TG was an inhibition factor for patients returning to normoglycaemia while both age and abdominal obesity were risk factors for the development of diabetes in the Inner Mongolian population.

0utcomes and correlated factors in patients with impaired fasting glucose: a ten-year follow-up analysis / 中华流行病学杂志

Objective To investigate the outcomes and relative risk factors in subjects with impaired fasting glucose in Inner Mongolia,China.Method A total number of 32 villages in Kezuohou Banner and Naiman areas in Inner Mongolia were selected as the baseline surveys study fields from 2002 to 2003.Patients with IFG(5.6 mmol/L≤FPG＜7.0 mmol/L) but without history of diabetes were selected as the study subjects.A follow-up study was conducted in 2013.Multinomial logistic regression analysis was used to evaluate the correlated factors.Results There were 384 patients with IFG recruited in the study.Out of them,150 (39.1％) progressed to normoglycaemia,174 (45.3％) remained as IFG,and 60 (15.6％) developed into type 2 diabetes mellitus.Through adjustment multivariately,patients that returning to the status of normoglycaemia were significantly associated under the function of TG (OR=0.692,95％CI:0.502-0.952,P＜0.05) and those developed to diabetes were significantly associated with factors as age (OR=1.052,95％CI:1.014-1.090,P＜ 0.05) or obesity (OR=2.924,95％ CI:1.353-6.320,P＜0.05).Conclusion 15.6％ of the IFG patients developed diabetes mellitus among the Inner Mongolian population.Elevated TG was an inhibition factor for patients returning to normoglycaemia while both age and abdominal obesity were risk factors for the development of diabetes in the Inner Mongolian population.

Correlation of bilirubin at the time of admission and the composite outcome in acute ischemic stroke dis?charged patient / 中国神经精神疾病杂志

Objective To explore the association of serum bilirubin level at the time of admission with the compos?ite outcome（disability or death）in discharged patients with acute ischemic stroke. Methods In a retrospective cohortstudy from June 1st 2009 to May 31st 2012, we continuously included 3151 patients with acute ischemic stroke and col?lected demography,lifestyle,clinical manifestations and laboratory test data. Functional outcome was measured with themodified Rankin scale (mRS) when subjects were discharged. Disability was defined as mRS≥3 and composite outcomewas defined as mRS≥3 or death. Serum bilirubin was divided into four groups according to the quartile. Multiple Coxregression analysis was used to assess the independent relation between serum bilirubin and disability death and the com?posite outcome. Results There were 407 disabled patients，the disability rate was 12.9%；and 104 patients were dead，the fatality rate was 3.3%.After adjusting for multiple factors, we found the risks of composite outcome with total bilirubin in the four quartile were higher than that in the first quartile, aHR and 95%CI were 1.335(1.047～1.702) respectively；The risks of composite outcome with indirect bilirubin in the four quartile were higher than that in the first quartile, aHR and 95%CI were 1.355(1.062～1.728) respectively; The risks of composite outcome with bilirubin direct in the third and the forth quartile were higher than that in the first quartile, aHR and 95% CI were11.403(1.089～1.807)and 1.431 (1.118～1.833) respectively.With the increase of total bilirubin，indirect bilirubin and direct bilirubin level，the compos?ite outcome of discharged patient was on the increase. Conclusions The study indicated that higher serum bilirubincould increase the risk of composite outcome in ischemic stroke patients, there was dose-response relationship ,and bili?rubin was a independent risk factor.

Association between insulin resistance and primary hypertension in Chinese Mongolian population / 中国组织工程研究

BACKGROUND: Insulin resistance may be a risk factor for hypertension,but the relationship between insulin resistance and hypertension are quite different from different race or nationalities. OBJECTIVE: To analyze the relationship between insulin resistance and hypertension in Chinese Mongolian population.DESIGN: Prevalent investigation.SETTING: Staff Room of Epidemiology, Public Health College of Harbin Medical University. PARTICIPANTS: Totally 232 patients with primary hypertension and persons with normal blood pressure, aged from 30-60 years from Kezuohouqi of Tongliao city in June 2001 based on the prevalent survey, and they all Mongoloid population. Examination was performed and blood pressure was measured. They were involved in this investigation after signing the consent. Other cardiovascular disease patients were excluded.METHODS: A total of 115 patients with primary hypertension and 117normotensives were selected with cluster sampling method. Height, body mass, waistline, hip line and waist-to hip ratio (WHR), I.e. Waist line/ hip line were standardization method. Body mass index (BMI) ＜ 24 kg/m2 or waist-to-hip ratio (WHR) ＜ 0.9, body mass or somatotype was partial to normal. Blood glucose was detected with glucose meter. Radio-immunoassay (RIA) were utilized to measure insulin and C-peptide. Degree of insulin resistance was determined by means of insulin sensitivity index (ISI), ISI =-ln [glucose (mmol/L) × insulin (Mu/L)]. After considering the effect of BMI and WHR as well as the stratification of BMI (≥24 kg/m2 and ＜ 24 kg/m2) and WHR (≥ 0.9 and ＜ 0.9), statistical analysis was performed. MAIN OUTCOME MEASURES: ISI of the investigational subjects of the two groups. RESULTS: Totally 232 included investigational subjects were involved in the result analysis, without drop out. ①Comparison of ISI of the investigational subjects of the two groups: The ISI of the hypertension group was slightly lower than that of the normotensive group, but the difference was not significant [-3.56±0.27,-3.50±0.20(P ＞ 0.05)]. ②Comparison of ISI of the investigational subjects of the two groups after delamination according to BMI and WHR: When the BMI was less than 24, the ISI in the hypertension group was lower distinctly than that in the normotensive group [-3.56+0.27,-3.48±0.17(F=5.037, P ＜ 0.05)]. When the WHR was less than 0.9, the ISI of the hypertension group was lower dramatically than that in the normotensive group [-3.57+0.27,-3.49+0.20(F=4.537, P ＜ 0.05 )].CONCLUSION: The insulin resistance may be related to primary hypertension in non-obese Chinese Mongolian population.