Reaction between antineoplastic nitidine chloride and sodium hydroxide solution / 第二军医大学学报

Objective: To challenge the previously proposed anticancer mechanism of nitidine chloride, which suggest there exist anti tumor C(6)=N(5) double bond structure. Methods: An antitumor alkaloid, nitidine chloride, was treated in aqueous sodium hydroxide solution without the presence of certain kinds of amino acids and oxygen. Results and Conclusion: It had been revealed that virtually equal amount of 5, 6 dihydronitidine and oxynitidine was produced under such circumstances. The results suggest the anticancer mechanism of nitidine chloride need further investigation. [

Synthesis and Antithrombotic Effect of CI-930 / 第二军医大学学报

A novel cardiotonic CJ-930 was successfully designed and synthesized with a new synthetic route. The method and reactive condition on acylating, hydrolytic and condensating reaction were also improved.In addition to convenience of operation, a new synthetic route showed also the advantage over Sircar's method on the raising of total yield 26% to 36%.This compound significantly inhibited the in vitro aggregation of rabbit platelet induced by arachidonic acid, U46619, collagen, ADP and platelet activating factor(PAF). In rabbit or rat platelet, CI-930 depressed the synthesis of thromboxane A.