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Objective To observe the efficacy of somatostatin on elderly patients with acute suppurative cholecystitis and its impact on the C-reactive protein (CRP), prealbumin (PA) and total bilirubin (TBIL) effects before or after operation. Method 110 elderly patients with acute suppurative cholecystitis, which from January 2011 to June 2013, were randomly divided into observation group and control group, each group had 55 cases, the control group were gave operation, the observation group were treated with somatostatin on basis of control group before and after operation. The operative time, blood loss, postoperative visual analog scale (VAS) score and morbidity were observed. At the same time, the levels of CRP, PA and TBIL were detected before and after operation. Results After treatment, the blood loss, postoperative hospital stay and postoperative complication rate in observation group were significantly lower than those in control group (P<0.01), while the differences in operative time and postoperative VAS score between two groups were not significant . After treatment, the levels of CRP, and TBIL appear significantly lower than those before treatment (P<0.01), while the PA levels appear significantly higher compared with those before treatment (P<0.01), the decreasing or increasing levels in observation group were more obvious compared with control group (P<0.01). Conclusion The adjuvant therapy efficacy of somatostatin were obvious before and after operation, they can significantly reduce the body's inflammatory response, and promote the postoperative recovery.
RESUMO
Objective To investigate the differentiation of neuroendocrine component (NEC) in colorectal adenocarcinoma in relation to its significance by comparing the outcome between patients with or without NEC.Methods The paraffin sections from patients with pathologically confirmed colorectal adenocarcinoma were retrospectively collected and screened for those with NEC by morphological examination and immunohistochemistry with neuroendocrine markers.Control patients (n=54) without NEC were selected from colorectal cancer database and 2: 1 matched on the basis of clinical features with NEC positive patients (n=27).Relative analysis was performed between two groups.Results With a median follow-up of 72 months,the 5-year disease free survival was 58.0% (16/27) in NEC positive group and 79.1% (43/54) in control group (P=0.036).Similarly,the 5-year cancer-specific overall survival was significantly lower in NEC positive group than in control group (58.3% versus 81.1%,P=0.037).Cox regression showed that the 5-year cumulative risks of disease recurrence and cancer-caused death in NEC positive patients were 2.38 and 2.41 times higher than those in control patients,respectively.Conclusions NEC appears to bear a poor prognosis in patients with colorectal adenocarcinoma.