Preparation of nasal thermosensible gels of Chinese medicine Xingbi and release behavior in vitro / 中国中药杂志

<p><b>OBJECTIVE</b>To prepare the nasal thermosensible gels of Chinese medicine Xingbi and study the release mechanism.</p><p><b>METHOD</b>The gels were prepared by using P407 as the gel matrix and P188 and PEG 6000 were used to adjust the gelatination temperature. The formulations were screened by the method of orthogonal test. Mathematic models were used to imitate the drug release.</p><p><b>RESULT</b>20% poloxmar 407, 2% poloxmar 188 and 2% PEG 6000 were suitable to Chinese medicine Xingbi thermosensitive gel in situ. Nasal thermosensible gels of Chinese medicine Xingbi was gelated at the temperature between 32-34 degrees C and the dissolution curves in vitro showed that the drug release could be best described by the Higuchi equation.</p><p><b>CONCLUSION</b>The formulation of the nasal thermosensible gels of Chinese medicine Xingbi is reasonable and it is worth doing further research.</p>

Determination of tanshinol and protocatechuic aldehyde in shenkangling granula by HPLC / 中国中药杂志

<p><b>OBJECTIVE</b>To develop an HPLC method for gradient elution determination of danshensu and protocatechuic aldehyde in Shengkangling granula.</p><p><b>METHOD</b>The analysis was carried on a column of Hypersil ODS2-C18 with a mobile phase consisted of methanol-1% glacial acetic acid 0-8 min (5:95), 8-11 min (6:94-5:95), 11-20 min (5:95) gradient elution at the flow rate of 1 mL x min(-1). The detection wavelength was 280 nm.</p><p><b>RESULT</b>The linearity was obtained in the range of 0.0504-0.504 microg (r = 0.9998) for tanshinol and 0.1090-1.090 microg (r = 0.9999) for protocatechuic aldehyde, respectively. The average recoveries of tanshinol and protocatechuic aldehyde in Shenkangling granula were 98.40% and 98.85%, and the RSDs were all less than 2.0%.</p><p><b>CONCLUSION</b>The method is simple, accurate and rapid. It may be suitable for the usual quality control of tanshinol and protocatechuic aldehyde in Shengkangling granula.</p>