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Artigo em Inglês | IMSEAR | ID: sea-163309

RESUMO

Aims: To determine antioxidant, cytotoxic and antimicrobial activities of organic extracts from leaves of Acridocarpous orientalis (qafas) from Sultanate of Oman. Study Design: Brine shrimp test, DPPH assay and Disc diffusion method. Place and Duration of Study: School of Pharmacy, University of Nizwa, Oman, December 2012. Methodology: Hexane, chloroform, ethylacetate and hydroalcoholic extract were obtained by Kupchan’s partitioning of ethanol extract isolated from leaves of A. orientalis by maceration. Antioxidant activity was determined by free radical scavenging of (2,2- diphenyl-1-picrylhydrazyl, DPPH). The antimicrobial activity was checked using agar disc diffusion method against Gram-positive bacteria (Staphylococcus aureus) and two Gramnegative bacteria (Escherichia coli and Pseudomonus aeruginosa). Brine shrimp test was used to measure cytotoxic activity. Results: All extracts demonstrated potential antioxidant activities, hydroalcoholic extract showed the strongest activity (RC50 = 6.11 g/ml). The order of antioxidant activity was hydro alcohol > ethyl acetate > chloroform > hexane extract. Ethylacetate extract showed low activity against Pseudomonus aeruginosa. None of the extracts was found to be active against brine shrimp larvae. Conclusion: A. orientalis could be considered as a good source of antioxidant compounds.


Assuntos
Antibacterianos/análise , Antibacterianos/química , Antibacterianos/farmacologia , Anti-Infecciosos/análise , Anti-Infecciosos/química , Anti-Infecciosos/farmacologia , Antineoplásicos/análise , Antineoplásicos/química , Antineoplásicos/farmacologia , Antioxidantes/análise , Antioxidantes/química , Antioxidantes/farmacologia , Técnicas In Vitro , Malpighiaceae/química , Omã , Folhas de Planta/química , Folhas de Planta/farmacologia
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