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Chinese Journal of Oncology ; (12): 702-705, 2008.
Artigo em Chinês | WPRIM | ID: wpr-255598

RESUMO

<p><b>OBJECTIVE</b>To evaluate the significance of a panel of immunohistochemical markers for distinguishing hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (ICC).</p><p><b>METHODS</b>Ten markers including hepatocyte paraffin 1 (Hep Par 1), polyclonal carcinoembryonic antigen (pCEA), CD34, CD10, CD105, multidrug resistance-associated protein-3 (MRP-3), cyclooxygenase-2 (COX-2), mucinous glycoprotein-1 (MUC-1), aquaporin-1 (AQP-1) and CK19 were immunohistochemically stained in the samples from 90 surgically resected HCC and 80 ICC, respectively,and the positive rate of their expression were compared statistically.</p><p><b>RESULTS</b>The positive expression rates of Hep Par 1, pCEA, CD34, CD10, CD105, MRP-3, COX-2 were 85.6%, 82.2%, 87.8%, 18.9%, 8.9%, 11.1% and 48.9%, respectively, in HCC. While the positive expression rates of MUC-1, AQP-1 and CK19 were 73.8%, 65% and 92.5%, respectively, in ICC.</p><p><b>CONCLUSION</b>Based on our results, Hep Par 1 and CD34 can be used as the first line markers, and pCEA and COX-2 as the second line makers, for differential diagnosis of hepatocellular carcinoma from intrahepatic cholangiocarcinoma. While MUC-1 and CK19 can be used as the first line markers and AQP-1 as the second one for the differential diagnosis of intrahepatic cholangiocarcinoma from hepatocellular carcinoma.</p>


Assuntos
Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias dos Ductos Biliares , Química , Diagnóstico , Ductos Biliares Intra-Hepáticos , Química , Biomarcadores Tumorais , Carcinoma Hepatocelular , Química , Diagnóstico , Colangiocarcinoma , Química , Diagnóstico , Diagnóstico Diferencial , Hepatócitos , Química , Patologia , Imuno-Histoquímica , Neoplasias Hepáticas , Química , Diagnóstico
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