RESUMO
<p><b>OBJECTIVE</b>To observe the effect of transplantation of allogeneic adipose-derived stem cells (ADSCs) on serum biochemical indicators and sporting ability in highly endurance-trained rats from a fasciological perspective.</p><p><b>METHODS</b>The ADSCs were cultured in vitro. Forty male Wistar rats were randomized into 4 equal groups, namely the blank control group, overtraining (model) group, transplantation without training group and overtraining plus transplantation group. The rats in the two overtraining groups were subjected to exhaustive swimming for 1 week, and in the two transplantation groups, cultured allogeneic ADSCs (2×10(6)/ml) were injected via the tail vein. The exhaustion time in swimming and the serum levels of BUN, LDH, BLa, and Hb of the rats were recorded after the treatments.</p><p><b>RESULTS</b>The rats in the model group showed significantly increased serum BUN, LDH and BLa levels and decreased Hb level with a extended exhaustion time as compared with those in the blank control group (P<0.01). The BUN, LDH and BLa was significantly lower, Hb level higher and the exhaustion time significantly longer in the overtraining plus transplantation group than those in the model group (P<0.01).</p><p><b>CONCLUSIONS</b>ADSCs can effectively prolong the exhaustion time of rats during exhaustive swimming and enhance their sporting ability.</p>
Assuntos
Animais , Masculino , Ratos , Tecido Adiposo , Biologia Celular , Nitrogênio da Ureia Sanguínea , Fadiga , Hidroliases , Sangue , Ácido Láctico , Sangue , Condicionamento Físico Animal , Fisiologia , Esforço Físico , Fisiologia , Ratos Wistar , Transplante de Células-Tronco , Métodos , NataçãoRESUMO
ObjectiveTo compare the results of controlled- release glipizide and immediate-re- lease glipizide in treating type 2 diabetes mellitus.Methods22 patients took controlled-release glipi- zide as treating group, 20 took immediate-release glipizide as compared. The glucose tolerance, insulin, C- peptide and HbA1c were measured before and after treatment. ResultsBoth of controlled-release glipizide and immediate-release glipizide had good results for controlling blood sugar, but controlled-re- lease glipizide did not increase insulin and C-peptide level. Conclusion The controlled-release glipizide had safe and reliable results for controlling blood sugar and decreasing insulin resistence.