Curative efficacy of Angelica containing selenium in treatment of chronic renal failure and its effects on Micro-inflammatory state / 国际检验医学杂志

Objective To study curative efficacy of Angelica containing selenium in treatment of chronic renal failure and its effects on Micro-inflammatory state.Methods A total of 80 patients of chronic renal failure who received therapy from March 2014 to March 2015 in our hospital were selected as research objects,and divided into observation group and control group,40 patients in each group.The control group was treated with routine treatment,while the observation group was treated with routine treatment with selenium enriched Angelica.Then renal function indicators including blood urea nitrogen(BUN),serum creatinine (SCr),hemoglobin(Hb)levels changes,micro inflammatory state including C reactive protein(CRP),interleukin-6 (IL-6),tumor necrosis factor (TNF-a) level changes,TCM syndrome points,treatment efficacy of two groups before and after treatment were compared.Results After treatment,BUN,SCr in observation group were less than those in the control group[(16.08±3.29)mmol/L vs.(21.50±3.68)mmol/L,(330.21±81.96)μmol/L vs.(390.86±84.24)μmol/L],Hb was higher than that in the control group[(107.38±7.37)g/L vs.(98.27±6.36)g/L](P<0.05).CRP,IL-6,TNF-α in observation group were less than those the control group[(5.92±1.14)mg/L vs.(7.26±2.02)mg/L,(24.75±7.12)pg/mL vs.(41.08±9.07)pg/mL,(112.16±20.16)ng/L vs.(134.46±22.16)ng/L],the differences were statistically significant(P<0.05).The score of TCM syndrome in observation group was smaller than that in control group[(5.01±1.21)score vs.(9.36±2.43)score],the difference was statistically significant(P<0.05).The total effective rate of the observation group after therapy was better than the control group[95.00%(38/40) vs.75.00%(30/40)],The difference was statistically significant(P<0.05).Conclusion Angelica containing selenium is well for chronic renal failure,which could effectively improve the micro inflammatory state,and could improve the therapeutic effect.

Analysis of prevalence and risk factors of hyperuricemia in subjects undergoing routine physical examinations in Guangzhou / 南方医科大学学报

<p><b>OBJECTIVE</b>To investigate the prevalence and risk factors of hyperuricemia in the subjects undergoing routine physical examinations in Guangzhou.</p><p><b>METHODS</b>This study was conducted among 8302 subjects (5136 male and 3166 female) undergoing routine physical examinations in a hospital in Guangzhou during the period from October 1, 2010 and December 31, 2011. For all the subjects, such indices as body height, weight, waist circumference, hip circumference, blood pressure, heart rate, and blood biochemistry were examined, and the body mass index (BMI) and waist-hip ratio were calculated. The risk factors of hyperuricemia were analyzed using univariate and multivariate logistic regression analysis.</p><p><b>RESULTS</b>Hyperuricemia was detected in 35.68% of the total subjects, and the detection rates were significantly higher in male than in female subjects (46.83% vs 17.59%, P<0.0001). Unconditional logistic regression analysis showed a significant correlation of hyperuricemia with age, sex, BMI, hypertension, waist-hip ratio, triglycerides, low-density lipoprotein (LDL), very low-density lipoprotein cholesterol (VLDL-C), creatinine, and blood urea nitrogen (P<0.05). Multivariate logistic regression analysis identified BMI, blood pressure, waist-hip ratio, hypertriglyceridemia, LDL, VLDL-C, creatinine, and urea nitrogen as the risk factors for hyperuricemia, and age and gender were negatively correlated with the incidence of hyperuricemia with OR values of 0.991 and 0.660, respectively.</p><p><b>CONCLUSION</b>Hyperuricemia has a high prevalence in the subjects undergoing routine physical examinations in Guangzhou. The risk factors of hyperuricemia include hypertension, hypertriglyceridemia, and elevations of BMI, waist-hip ratio, LDL, VLDL-C, creatinine, and blood urea nitrogen. Age and gender can be protective factors against hyperuricemia.</p>

Effects of Sheng Mai San on the level of cell factors induced by lipopolysaccharide in chronic liver failure rats / 中国医师杂志

Objective To study the Sheng Mai San on the levels of cell factors induced by lipopolysaccharide in acute liver failure rats. Methods The models of chronic liver failure were constructed by injecting CCl4 in the abdomen of rats. The serum levels of lipopolysaccharide and cell factors were determined after treating with LPS and Sheng Mai San for 2 hours. Results The serum level of IL-6［(64.50±18.79)pg/ml vs (4.79±0.57)pg/ml］, ICAM-1［(25100.00±5258.85)pg/ml vs (4215.50±942.79)pg/ml］ and TNF-α［(17.55±2.39)pg/ml vs (10.92±5.02)pg/ml］ was increased by CCl4 (P＜0.05), but there is no effect on the serum level of LPS in rats ［(0.058±0.007)EU/ml vs (0.040±0.002)EU/ml,P＞0.05］. Sheng Mai San can significantly reduce the serum level of IL-6, ICAM-1 and TNF-α in rats with acute liver failure induced by CCl4 ［(17.20±3.12)pg/ml,(9490.00±2725.78)pg/ml,(3.00±1.00)pg/ml,P＜0.05］. After treating with LPS for 2 hours, the serum level of LPS, TNF-α, IL-6, ICAM-1 markedly increased ［(0.501±0.019)EU/ml,(19750.00±9655.17)pg/ml,(5615.00±490.50)pg/ml,(41000.00±589.88)pg/ml,P＜0.01］. Sheng Mai San could reduce the serum levels of LPS, TNF-α, IL-6, ICAM-1 and in rats with chronic liver failure (P＜0.01). Conclusions SD Rats in the state of chronic liver fail-ure, existing serious serum endotoxin, can induce the levels of cell factors by diversification inflammation reaction and. ShengMaiSan can regulating the levels of cell factors in rats with chronic liver failure.

The role of beta irradiation on neointimal formation and apoptosis in vein grafts model / 中华外科杂志

<p><b>OBJECTIVE</b>To evaluate the effect of beta irradiation on intimal proliferation and apoptosis in vein grafts.</p><p><b>METHODS</b>Autogenous vein graft model was established in 80 rats by transplanting the internal branch of the jugular vein to the carotid artery by end to end anastomosis. The veins were irradiated by (32)P solution before anastomosis. Two dose schedules were studied: control group (graft, nonirradiated) and radiation group (20 Gy). The grafted veins were harvested at 3, 1, 2 and 4 week respectively after the operation. intimal hyperplasia (IH), smooth muscle cell (SMC), proliferation, p53, bcl-2 and bax were observed pathologically and immunohistochemically. They were analyzed by a computerized system. The presence of apoptotic VSMC was demonstrated by TUNEL method.</p><p><b>RESULT</b>There was a significant decrease in the average intimal thickness at 7, 14 and 28 days (t = 15.694, P < 0.05) in the radiation group. Immunohistochemical analysis of PCNA indicated decreased positive cells in the radiation group compared with the controls at 1 and 2 weeks (t = 60.157, P < 0.01). Apoptosis of VSMC was higher in the radiation group than in the control group at 2 weeks (t = 56.176, P < 0.01). There was no significant difference in expression of P(53) between the two groups, and there was a significant increase in bax/bcl-2 in the radiation group at 2 weeks (t = 9.783, P < 0.05).</p><p><b>CONCLUSION</b>These preliminary results demonstrated that low dose of beta irradiation in the vein graft inhibits SMC proliferation and induces the apoptosis of VSMC in rats.</p>

Discussion on Construction of University Students' Social Duty for Harmonious Society / 中华医学教育探索杂志

Social duty is an important component of university students' moral quality and a weak link of current students' comprehensive quality.University education should pay adequate attention to and reinforce this link,look for reasons from society,university,family and etc,take corresponding measures,culture and construct university students' social duty,improve their comprehensive quality to adapt to the need for the great goal of building socialistic harmonious society.

Influence of Literary Fashion on Contemporary University Students and the Countermeasures / 中华医学教育探索杂志

Fashion literary is profoundly affecting higher school students'ideological and cultural concept,while answering their material and spiritual demands.The paper holds that discussing the enlightenment of fashion literary and proposing new measures is an important topic on the ideological and political education of higher schools,since fashion literary is applauded by university students and can successfully give them profound influence.

Expression of E-cadherin and ?-catenin in breast carcinoma and its′ significance / 中国普通外科杂志

Objective To detect the expression of E-cadherin and ?-catenin in breast carcinoma and analyze the relationship between E-cadherin and ?-catenin and the clinicopathological features. Methods The expression of E-cadherin and ?-catenin in breast cancer, paracarcinoma breast tissue, simple mastoplasia and atypical mastoplasia were detected by immunohistochemical method and the results were compared. Results The abnormal expression rates of E-cadherin and ?-catenin in breast cancer tissue were 51.9% and 61.1 %,respectively. Abnormal expression of E-cadherin was significantly correlated with histological grade. Abnormal expression of ?-catenin was significantly correlated with TNM staging, axillary lymph nodes metastasis and postoperative distant metastasis. COX multiple factor analysis showed that neither E-cadherin nor ?-catenin expression was an independent indicator for the prognosis of breast cancer. Conclusions Abnormal expressions of E-cadherin and ?-catenin are correlated with occurrence and development of breast carcinoma. Abnormal expressions of E-cadherin and ?-catenin are good indicators to judge invasion and metastasis of breast carcinoma.

Ductal carcinoma in situ of breast:a report of 123 cases / 中国普通外科杂志

Objective In order to deeper understand DCIS,improve the rate of diagnosis and therapeutic efficacy.Methods The clinical data of 123 DCIS treated at the First Affiliated Hospital of China Medical University were retrospectively analyzed in regards to age at onset of disease,clinical features,breast ultrasound examination,mammography examination,pathology,immunohistochemistry examination,and surgical methods.Results(1) The average age at onset was(47.7?9.3) years.(2)The major features on physical examination were breast lump in 79cases,nipple discharge in 19cases,and breast pain with glandular thickening in 30 cases.(3)Among 45 cases that underwent both ultrasound and mammography examination,in 17cases(60%) and 30 cases(66.7%) respectively,might be positive for malignancy,but the difference between the 2 melhods was not significant.With the use of both methods togather,diagmosis of possible malignant lesion was made in 37 cases(82.2%).(4) Sixty-five cases underwent breast ultrasound examination,substantive mass was found in 43 cases(66%),blood flow signals in 41 cases(63%),ductal dilatation in 52 cases(80%) and intraductal spotty strong light beam in 33 cases(50.7%).(5) Fifty-two cases underwent breast mammography examination,which showed sand-like calcification,mass with calcification clusters,localized gland density and breast tumor.(6)The immunohistochemistry examination included estrogen receptor(ER),progesterone receptor(PR),p53 and c-erbB-2,but the rate of positive expressios of those indices showed no significance difference between DCIS and DIS with microvasion(DCIS-MI).(7)Six cases underwent radical mastectomy(of which there were 3 cases of DCIS-MI).Modified radical mastectomy was done in 86 cases,including 59 cases of DCIS,27 cases of DCIS-MI.Lymph node metastasis was found in 2 cases of DCIS,and 5 cases of DCIS-MI.ConclusionsCombined breast ultrasound and mammography can increase the rate of DCIS diagnosis.

Mutation and expression of ?-catenin gene in breast cancer / 中国普通外科杂志

Objective To investigate the role of ?-catenin gene in breast tumorigenesis.Methods Mutation and expression of ?-catenin gene in 42 breast cancer tissues were detected by polymerase chain reaction-single strand conformation polymorphism and immunohistochemistry.Results The rate of abnormal expression of ?-catenin in breast cancer tissuse was 59.5%(25/42).Mutation of ?-catenin gene was not detected in breast cancer tissue.Conclusions Abnormal expression of ?-catenin plays an important role in human breast tumorigenesis,but the cause of abnormal expression of ?-catenin is not mutation of ?-catenin gene.