Research progress of microRNAs in sepsis-associated acute kidney injury / 中华危重病急救医学

Sepsis is a life-threatening organ dysfunction syndrome caused by the host's maladjusted response to infection, and is one of the important causes of acute kidney injury (AKI). Sepsis-associated acute kidney injury (SA-AKI) has a high incidence, poor prognosis and high mortality. The pathogenesis of SA-AKI is very complex, and its pathogenesis has not been fully elucidated. Therefore, finding effective biomarkers for early diagnosis, treatment, disease development and prognosis of SA-AKI is an urgent clinical problem.

Research progress in human breast milk microecology / 中华围产医学杂志

It is widely acknowledged that breast milk is the first choice for infant.The presence of complex commensal bacteria in human breast milk has been confirmed by traditional culture-dependent methods,while in recent years,some advanced technologies,such as next-generation sequencing,have revealed that a complex microbial ecosystem exist in human milk.Microbes in human breast milk has different origins,and its composition is influenced by various factors.Moreover,the micro-ecosystem of human breast milk,which is considered as an important source of infant intestinal flora,is vital for infants' growth and long-term health because of its antibacterial effect and abilities of promoting the growth of beneficial bacteria and regulating the immune system as well as intestinal nutrition metabolism.Hence,in-depth research on the complex microecosystem of human breast milk will be of great value.

Risk factors for left ventricular hypertrophy in children with chronic kidney disease / 临床儿科杂志

Objectives To investigate the prevalence of left ventricular hypertrophy (LVH) and risk factors in children with chronic kidney disease (CKD). Methods The biochemical indices, blood pressure and left ventricular mass index (LVMI) in pa-tients with CKD were retrospectively analyzed. The risk factors of LVH were analyzed using Logistic regression. Results In 125 CKD patients, 32.00%were at 4th stage and 68.00%were at 5th stage. The estimate glomerular ifltration rate (eGFR) and hemo-globin (Hb) level were signiifcantly higher in CKD patients at 4th stage than in those at 5th stage. The intact parathyroid hormone (iPTH), serum phosphorus and LVMI were signiifcantly lower in CKD patients at 4th stage than in those at 5th stage (P<0.01). LVH was detected in 33.60%CKD patients. The eGFR and Hb level were signiifcantly lower in CKD patients with LVH than in those without LVH. The iPTH, serum phosphorus, systolic blood pressure and diastolic blood pressure were signiifcantly higher in CKD patients with LVH than in those without LVH (P<0.05). Logistic regression analysis indicated that only hypertension, hyperphosphatemia, moderate and severe anemia were the risk factors of LVH. Conclusion Control of hypertension, hyperphos-phatemia and anemia is the key to prevent LVH in CKD patients.