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ObjectiveTo assess the epidemic trend of COVID-19 Omicron and the effectiveness of containment measures in Shanghai by estimating the time-varying reproduction number （Rt）. MethodsBased on the daily reported confirmed cases and asymptomatic infections in Shanghai from February 20 to April 26， 2022， the R package "Epiestim"， which was built by Bayesian framework method， was used to estimate the variation curve of Rt during the epidemic period and to analyze the trend of the epidemic. ResultsIn the early stage of the epidemic， after the implementation of school closure and nuclear acid screening in some communities， Rt continued to fluctuate between 2.000 and 3.000， reaching a peak of 2.740 （95%CI： 2.640‒2.830） on March 21， but began to decline around one week after the city lock-down on April 1. As of April 18， the Rt value in Shanghai was below the threshold of 1.000 for the first time， reaching 0.955 （95%CI： 0.951‒0.961）. ConclusionAfter the implementation of public health measures with increasing strength of containment in Shanghai， the transmission rate gradually decreased， reflecting the effectiveness of the interventions. In the actual prevention and control process， the containment work should not be relaxed in order to keep the Rt below 1.000.
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Objective:To evaluate the efficacy and safety of using platelet-rich plasma (PRP) eyedrops for the treatment of moderate to severe dry eye disease (DED).Methods:A total of 395 patients (790 eyes) with moderate to severe DED diagnosed and treated in the Armed Police Liaoning Corps Hospital and the PLA 967 Hospital from March 2018 to October 2019 were collected. Random number table method was used to divide into autologous PRP treatment group (196 cases, 392 eyes) treated with autologous PRP and control group (199 cases, 398 eyes) treated with artificial tears. The changes of subjective symptoms of DED, Schirmer test (ST), corneal fluorescein staining (CFS) and Ocular Surface Disease Index (OSDI) before and after treatment were observed in both groups.Results:After 1 course of treatment, the ST values of both groups increased, which was statistically significant compared with before treatment ( P<0.05). After treatment, the OSDI and CFS scores of the two groups were reduced. The difference in OSDI and CFS scores of the PRP treatment group before and after treatment was statistically significant ( P<0.05), and there was no statistically significant difference in the control group before and after treatment ( P>0.05). After treatment, the OSDI and CFS scores of the PRP treatment group were lower than those of the control group [(16.8 ± 18.7) scores vs. (43.2 ± 14.5) scores, (0.21 ± 0.53) scores vs. (1.62 ± 0.69) scores], the differences were statistically significant ( P<0.05). After one course of treatment, the total effective rate of the autologous PRP treatment group was higher than that of the control group [80.1% (157/196) vs. 51.76% (103/196)], the difference was statistically significant ( P<0.05). Conclusions:Autologous PRP can treat patients with moderate-to-severe autologous PRP treatment group, which can greatly improve patients' eye discomfort and other symptoms.
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Objective To evaluate the security of inspiring high concentration oxygen by detecting the reactive oxygen species of the rats brain homogenates after inspiring high concentration oxygen for a certain time.Methods Sixty wister rats weighting 150~200g were randomly devided into five groups(the group of 4h、8h、12h、16h and the control group,12/group).The experimental rats were exposed to 85%~100% oxygen in a self-made chamber and the control animals were kept in normal room air.The Concentration of the MDA,SOD,GSH,NO,NOS,CAT and T-AOC of the brain homogenates was detected.Results Compared with the control group,the level of MDA,NO and NOS in the brain homogenates grew up markedly(P