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Objective:To investigate the effect of bel canto breathing training method on the respiratory rehabilitation of patients with chronic obstructive pulmonary disease in stable stage.Methods:Using a quasi-experimental research method, 40 patients with chronic obstructive pulmonary disease in stable stage from September to December 2018 in two wards (the first ward and the second ward) with the same level of diagnosis and treatment of respiratory physicians, nurses' nursing ability and the ward environment of the First Hospital of Lanzhou University were selected. The first ward was used as the experimental group, and the second ward was used as the control group, there were 20 cases in each group. The patients in the experimental group were given bel canto breathing training and conventional breathing training, while the patients in the control group were given conventional breathing training. A WeChat group was established, and training videos were distributed in the WeChat group after discharge to urge patients to perform training. After 3 months of intervention, the quality of life, anxiety, depression, and pulmonary function were evaluated by St George′s Respiratory Questionnaire (SGRQ), Hospital Anxiety and Depression Scale (HADS), proportion of forced expiratory volume in forced vital capacity in the first second(FEV1/FVC).Results:The SGRQ score, HADS score and FEV1/FVC value in the experimental group before intervention respectively were (41.35 ± 9.94), (16.55 ± 4.29) points and (47.13 ± 8.85)%, at discharge respectively were (28.95 ± 5.66), (11.20 ± 2.75) points and (59.51 ± 10.49)% and after three months of intervention respectively were (21.75 ± 6.31), (7.15 ± 3.51) points and (66.69 ± 7.87)%, while the SGRQ score, HADS score and FEV1/FVC value in the control group before the intervention respectively were (42.10 ± 10.50), (16.60 ± 4.73) points and (46.23 ± 10.14)%, at discharge respectively were (34.90 ± 10.16), (13.35 ± 2.37) points and (52.91 ± 7.86)%, and after three months of intervention (35.80 ± 7.27), (14.20 ± 5.05) points and (52.65 ± 8.60)%. With the increase of the intervention time of bel canto breathing training, the SGRQ score and HADS score decreased ( F=29.65, 17.44, both P<0.05), and the FEV1/FVC value increased ( F=27.38, P<0.05). Within-group comparisons the SGRQ score, HADS score, and FEV1/FVC value in the experimental group at discharge, three months after the intervention versus pre-intervention, and three months after the intervention versus discharge showed statistically significant differences ( t values were -7.73 - 7.38, all P<0.05). SGRQ score, HADS score, and FEV1/FVC value in the control group were only statistically significant at discharge versus pre-intervention ( t=-4.63, -2.79, 5.28, all P<0.05). The SGRQ, HADS score and FEV1/FVC value between the 2 groups were not statistically significant before the intervention, but statistically significant at discharge and three months after the intervention ( t values were -6.53 - 5.39, all P<0.05). Conclusions:Bel canto breathing training can improve the quality of life, reduce anxiety, depression and increase FEV1/FVC in patients with chronic obstructive pulmonary disease in stable stage.
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Doxorubicin is an effective anthracycline chemotherapeutic drug, which is widely used in single or combined chemotherapy for various malignant tumors. However, the cardiotoxicity caused by doxorubicin has limited its clinical application. Despite a large amount of research investment, no suitable target has been found to reduce cardiotoxicity caused by doxorubicin while guaranteeing the effect of chemotherapy. Recent studies have found that non-coding RNA is related to doxorubicin-induced cardiomyopathy. Further explaining the relationship between the two may provide new strategies for the diagnosis, prevention and treatment of doxorubicin-induced cardiotoxicity.
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【Objective】 To investigate and summarize the clinical and imaging features of a few patients with coronavirus disease 2019 (COVID-19) in Lanzhou City. 【Methods】 We carried out a retrospective analysis of the epidemiological data, laboratory results and clinical imaging features of eight hospitalized patients with confirmed COVID-19 in The First Hospital of Lanzhou University from January 23 to February 23, 2020. 【Results】 The sex ratio (men to women) of the 8 patients was 5∶3 while their age ranged from 24 to 57 years old. The incubation period was 1-10 days. Of the 8 patients, 7(87.5%) had COVID-19 brought in from other places in China and 1(12.5%) was a secondary infection case. The main clinical manifestations included cough in 6 cases (75%), fever in 4 cases (50%), expectoration in 3 cases (37.5%), and fatigue in 2 cases (25%). All the 8 cases indicated abnormal manifestations in blood routine examinations, 4 cases (50%) decreased in WBC, 7 cases (87.5%) decreased in Lym count, 5 cases (62.5%) increased in LDH, 1 case (12.5%) increased in CK, 1 case(12.5%) increased in CK-MB, 4 cases (50%) increased in CRP, 2 cases (25%) increased in PCT, and 1 case (12.5%) increased in D-dimer. Of the 2 patients examined by chest digital radiography (DR), one DR finding was not typical and the other one suggested increased bilateral lung markings. Six patients were examined by HRCT, of whom four (50%) showed multiple ground glass opacities on both lobes and two (25%) showed multiple ground glass opacities only on the right lobe; none of the 6 imaging findings suggested pleural effusion. Six patients were discharged from hospital after being cured and 1 patient still underwent treatment. 【Conclusion】 Most of these 8 patients had COVID-19 imported from outside the city, and the patients were relatively young with few underlying diseases. Their major symptoms were fever, cough, and expectoration. All of them exhibited abnormal findings in blood routine examinations; half of them suggested increased CRP while a few ones showed abnormal CK and Ddimer values. The imaging manifestations of most patients were multiple ground glass opacities near the peripheral pleura.
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Objective·To compare the efficacy of video-assisted thoracic surgery (VATS) and conventional lung volume reduction surgery for the treatment of patients with severe chronic obstructive pulmonary disease with a meta-analysis.Methods·Randomized controlled trials (RCT) and non-randomized control studies of VATS (the VATS group) and conventional lung volume reduction surgery (the thoracotomy group) for treating patients with severe chronic obstructive pulmonary disease were collected from databases,including Web of Science,EMbase,PubMed,the Cochrane Library,CNKI,CBM disc,WanFang Data,and VIP.The latest literature was published in November 2016.The assessment included the quality of literature and RevMan5.3 software was used to perform the meta-analysis.Results·Of 779 retrieved articles,12 studies involving 966 patients were included according to the inclusion criteria.The results of meta-analysis showed that the operation time of bilateral LVRS was longer in the VATS group than in the thoracotomy group,but the difference in the operation time of single LVRS between the two groups was not statistically significant.The difference in the duration of chest tube drainage for bilateral LVRS between the two groups was not statistically significant,while the duration of chest tube drainage for single LVRS was significantly shorter in the VATS group than in the thoracotomy group.The amount of intraoperative blood loss postoperative drainage was significantly smaller in the VATS group than in the thoraeotomy group.Postoperative pulmonary function and blood gas analysis showed that the 6 min walking distance was longer in the VATS group than in the thoracotomy group.The differences in FEV1 and PaO2 between the two groups were not statistically significant,as well as the difference in postoperative complications between the two groups.Conclusion·Comparing to conventional lung volume reduction surgery,Video-Assisted thoracic lung volume reduction surgery is a better choice.However,randomized control trials with higher quality and larger scale are required for verification this conclusion due to limitations of the quality and samples of these studies.