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Objective:To analyze the clinical characteristics and prognosis of pregnant women with hemorrhagic fever with renal syndrome (HFRS).Methods:A total of 11 pregnant women with HFRS admitted to The Second Affiliated Hospital of Xi′an Jiaotong University (four cases), The Second Affiliated Hospital of Air Force Medical University (four cases), The First Affiliated Hospital of Xi′an Jiaotong University (one case) and Central Hospital of Xianyang City (two cases) between November 2009 and February 2019 were included as the study group, and 24 age-matched non-pregnant women with HFRS were selected as the control group. The age, complications, clinical classification and laboratory indexes of the two groups were analyzed retrospectively, and the clinical outcomes of pregnant women and their fetuses in the study group were followed up. The data between two groups were compared using Mann-Whitney U test or chi-square test. Results:Patients in the study and control groups were 29 (22, 33) and 32 (24, 37) years old, respectively. Seven of 11 patients in study group were severe and critical cases, which was significantly higher than that in the control group (16.7%(4/24), χ2=7.722, P=0.015). In the study group, 10 patients had hypervolemic syndrome, 10 patients had pulmonary edema and six patients had overlapping hypotension shock phase and oliguria phase, which were all higher than those in the control group ((2/24, 8.3%), (2/24, 8.3%) and (2/24, 8.3%), respectively; χ2=22.828, 22.828 and 9.135, respectively, all P<0.01). Compared with the control group, the pregnant patients in study group had a higher urea nitrogen maximum and serum creatinine maximum, and the differences were both statistically significant ( Z=-2.453 and -2.336, respectively, both P<0.05), while they had a lower serum albumin minimum, hemoglobin maximum and hemoglobin minimum, and the differences were all statistically significant ( Z=-3.742, -3.350 and -4.034, respectively, all P<0.01). All pregnant women with HFRS recovered. Nine pregnant women gave birth to nine healthy infants. All of them received breastfeeding and the feeding duration were more than six months. No abnormal growth and development were found during an average follow-up of three years. Conclusions:Pregnancy can aggravate the severity of HFRS, and pregnant women have higher risk of the multiple stages overlap and the complications such as hypervolemic syndrome and acute pulmonary edema. After recovery from HFRS, mother may carry to full-term pregnancy.
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Objective To observe and investigate b-type natriuretic peptide(BNP)levels in patients with hemorrhagic fever of seriously renal syndromes line of continuous renal replacement therapy(CRRT)application value.Methods From January 2015 to October 2015 were 48 cases of patients with hemorrhagic fever of seriously renal syndromes as the research object.Conservative treatment after 3 d better person to be included in the control group(24cases), no better continue CRRT(CRRT group, 24cases).Records in the two groups before the conservative treatment in patients with mean arterial pressure(MAP), albumin(propagated), hemoglobin(Hb), b-type natriuretic peptide(BNP)and a 24 h urine(24 h urine);Record after conservative treatment 3 d urea nitrogen, serum creatinine, BNP and 24 h urine(24 h urine).Compare the differences between the two groups of the clinical indicators.Results The control group with CRRT group propagated, urea nitrogen, serum creatinine, BNP-I, BNP-Ⅱ, 24 h urine-Ⅰ, 24 h urine-Ⅱ comparison, the difference had statistical significance (P<0.05).Conclusion The short term the 24 h urine after conservative treatment and BNP levels can better predict whether patients with hemorrhagic fever of Seriously renal syndromes should be line of CRRT.