RESUMO
Objective To study the curative efficacy of oxycodone hydrochloride sustained release tablet combined with morphine tablets in the treatment of patients with severe cancer pain,and its influence on quality of life.Methods 80 patients with severe cancer pain were selected as research subjects.They were randomly divided into observation group and control group,45 cases in each group.The control group was treated with morphine tablets,while the observation group was treated with oxycodone hydrochloride sustained release tablet combined with morphine tablets.Then,the adverse reaction,quality of life score,pain relief were compared between the two groups.Results After treatment,there was no significant difference in the incidence of adverse reactions between the two groups (x2 =1.216,P ＞0.05).The appetite,sleep,daily activities,mental state,emotion,and interpersonal,life interest score in the observation group were lower than those in the control group[(3.20 ±0.78) points vs.(5.36 ±0.90) points,(2.80 ± 0.80)points vs.(4.39 ± 0.72) points,(3.40 ± 0.51) points vs.(4.98 ± 0.60) points,(2.33 ± 0.41) points vs.(4.58 ± 0.50) points,(3.59 ± 0.45) points vs.(5.90 ± 0.50) points,(3.56 ± 0.42) points vs.(4.98 ± 0.45) points,(3.18 ± 0.92) points vs.(5.87 ± 1.01) points,t =12.166,9.910,13.460,23.343,23.036,15.475,13.208,all P ＜0.05].The pain relief rate of the observation group was statistically higher than that of the control group[95.55％ (43/45) vs.80.00％ (36/45),x2 =5.075,P ＜ 0.05].Conclusion Oxycodone hydrochloride sustained release tablet combined with morphine tablets has significant effect on cancer patients,and it can alleviate the suffering of patients,improve the quality of life of patients.