Flattening the biological age curve by improving metabolic health: to taurine or not to taurine, that' s the question / 老年心脏病学杂志（英文版）

The aging population is an important issue around the world especially in developed countries. Although medical advances have substantially extended life span, the same cannot be said for the duration of health span. We are seeing increasing numbers of elderly people who are frail and/or have multiple chronic conditions; all of these can affect the quality of life of the elderly population as well as increase the burden on the healthcare system. Aging is mechanistically related to common medical conditions such as diabetes mellitus, ischemic heart disease, cognitive decline, and frailty. A recently accepted concept termed 'Accelerated Biological Aging' can be diagnosed when a person's biological age-as measured by biomarkers of DNA methylation-is older than their corresponding chronological age. Taurine, a conditionally essential amino acid, has received much attention in the past few years. A substantial number of animal studies have provided a strong scientific foundation suggesting that this amino acid can improve cellular and metabolic health, including blood glucose control, so much that it has been labelled one of the 'longevity amino acids'. In this review article, we propose the rationale that an adequately powered randomized-controlled-trial (RCT) is needed to confirm whether taurine can meaningfully improve metabolic and microbiome health, and biological age. This trial should incorporate certain elements in order to provide the much-needed evidence to guide doctors, and also the community at large, to determine whether this promising and inexpensive amino acid is useful in improving human metabolic health.

Quality management requirements of clinical mass spectrometry method in the United States / 中华检验医学杂志

Mass spectrometry technique has been very well received in the clinical lab since the commercial liquid chromatography tandem mass spectrometry instrument became available. As majority of the clinical mass spectrometry assays are lab developed tests without Food and Drug Administration clearance, proper quality management of a clinical mass spectrometry method is critical to ensure reliable testing results. Clinical and Laboratory Standards Institute guideline C62-A, a high standard and best practice guidance, has been published to address the quality management requirements of a clinical mass spectrometry method. This review describes quality management requirements of a mass spectrometry method during the development, validation, and daily operation in an accredited clinical lab in the United States. The consistency and standardization of quality management requirements of clinical mass spectrometry methods are not only the foundation of comparability of testing results, but remain as difficulties and challenges among labs.