RESUMO
BACKGROUND: Kaposi varicelliform eruption (KVE) is a disseminated viral infection primarily caused by the herpes simplex virus in the setting of an underlying chronic skin disease. Few studies have reported the clinical characteristics and predisposing factors for recurrent KVE.OBJECTIVES: To characterize the clinical features and predisposing factors for recurrent KVE.METHODS: This retrospective comparative study of recurrent vs. single-episode KVE was performed at the Pusan National University Hospital between 2004 and 2017.RESULTS: A total of 84 episodes occurred in 60 patients, and of these, 13 patients developed recurrence (21.7%). No statistically significant intergroup difference was observed in the mean age and sex distribution. The face was the most common site of involvement in both groups, followed by the trunk and the upper and lower extremities. Atopic dermatitis was the most common pre-existing disease in both groups; however, Darier's disease was more common in the recurrent KVE group, and this difference was statistically significant. Most patients with KVE (66.7%) showed aggravation of the underlying skin disease within 3 months of KVE onset. This finding was more prominent in patients with recurrent episodes (91.7%) than in those with single-episode KVE (58.3%), (p=0.040).CONCLUSION: This study can contribute to a better understanding of recurrent KVE and guide clinicians in treating patients with conditions predisposing to KVE.
Assuntos
Humanos , Causalidade , Doença de Darier , Dermatite Atópica , Erupção Variceliforme de Kaposi , Extremidade Inferior , Cobertura de Condição Pré-Existente , Recidiva , Estudos Retrospectivos , Distribuição por Sexo , Simplexvirus , DermatopatiasRESUMO
Dermatofibroma is a fibrohistiocytic tumor of the skin that commonly occurs as a solitary lesion on the lower extremities of young women. Multiple eruptive dermatofibromas (MEDFs), defined as the presence of 5 to 8 dermatofibromas appearing within a period of 4 months, are rare, and the etiology of MEDFs remains unknown. However, MEDFs are frequently thought to be associated with altered immunity, such as autoimmune diseases and immunosuppression. It is unclear why MEDFs occur in association with these conditions, but this relationship may suggest that MEDFs are the result of an abortive immunoreactive process. We herein describe a middle-aged woman who developed multiple dermatofibroma. She had myasthenia gravis for 8 years, and developed MEDFs after undergoing oral corticosteroid treatment (245 mg/week) for 3 months. Therefore, our case suggests that the use of immunosuppressants is a more dominant factor for the development of MEDFs than underlying autoimmune diseases.
Assuntos
Feminino , Humanos , Doenças Autoimunes , Histiocitoma Fibroso Benigno , Terapia de Imunossupressão , Imunossupressores , Extremidade Inferior , Miastenia Gravis , PeleRESUMO
No abstract available.
Assuntos
Dermoscopia , Cabelo , Hamartoma , Hipertricose , Músculo LisoRESUMO
Trichorhinophalangeal syndrome (TRPS) is a rare autosomal dominant hereditary disease caused by mutations in the TRPS1 or the EXT1 gene. Patients show 3 different forms (TRPS I-TRPS III) of this condition sharing similar clinical features including sparse hair, a bulbous nose, an elongated philtrum, short stature, and shortened phalanges. A 10-year-old girl presented with sparse hair and thin hair shafts since birth. She also showed a bulbous nose, an elongated philtrum, brachydactyly of the great toes, and a short stature. Radiological examination showed cone-shaped epiphyses and shortened phalanges. Genetic analysis revealed a novel missense mutation c.2759G>C (p.Trp920Ser) in the TRPS1 gene. We diagnosed this patient with TRPS type III. To our knowledge, only 3 reports have described a genetically analyzed TRPS1 gene mutation among the 11 reported cases of TRPS in the Korean literature. Furthermore, we identified a novel missense mutation in the TRPS1 gene.
Assuntos
Criança , Feminino , Humanos , Braquidactilia , Epífises , Doenças Genéticas Inatas , Cabelo , Lábio , Mutação de Sentido Incorreto , Nariz , Parto , Dedos do PéRESUMO
Granuloma annulare is a benign granulomatous skin disease, clinically characterized by dermal papules tending to form annular shapes. Granuloma annulare is classified into localized, generalized, subcutaneous, and perforating types. Localized granuloma annulare is likely to resolve spontaneously, while generalized granuloma annulare usually takes a chronic course. Topical steroids, phototherapy, isotretinoin, dapsone, hydroxychloroquine, and other various treatments have been proposed, but some cases have been resistant to all of those treatment modalities. We experienced 3 cases of generalized granuloma annulare demonstrating a recalcitrant course that were successfully treated with methotrexate and propose that methotrexate may be an effective option for recalcitrant generalized granuloma annulare treatment.
Assuntos
Dapsona , Granuloma Anular , Granuloma , Hidroxicloroquina , Isotretinoína , Metotrexato , Fototerapia , Dermatopatias , EsteroidesRESUMO
No abstract available.
Assuntos
Mãos , Hiperpigmentação , Deficiência de Vitamina B 12 , Vitamina B 12 , VitaminasRESUMO
BACKGROUND: Labial melanotic macules (LMMs) are benign pigmented lesions that usually take the shape of flat asymmetrical macules with tan-brown to black color and variable size. Whereas the dermoscopic features of other pigmented skin lesions have been relatively well described, little is known about LMMs. OBJECTIVE: To describe the dermoscopic features and find typical and schematic dermoscopic patterns in LMMs. METHODS: A retrospective dermoscopic study was conducted on 80 lesions with histopathologically proved LMMs. RESULTS: We described and defined, for the first time to our knowledge, landscape painting patterns found in 65 of 80 melanotic lesions (81.3%), characterized by parallel lines or circle lines, overlapping vessels with background brown pigmentation. The background brown pigmentations were observed in 74 of 80 lesions (92.5%), the parallel lines in 62 (77.5%), the circle lines in 20 (25.0%), and overlapping vessels in 69 (86.3%). The structureless black pigmentations were only presented in 26 of 80 (32.5%). CONCLUSION: Dermoscopy can be useful for the clinical detection of LMMs, and “Landscape painting patterns” may represent a dermoscopic clue for the diagnosis of these lesions.
Assuntos
Dermoscopia , Diagnóstico , Pintura , Pinturas , Pigmentação , Estudos Retrospectivos , PeleRESUMO
Unilateral linear capillaritis (ULC) is a rare variant of pigmented purpuric dermatosis (PPD). ULC is clinically characterized by unilateral linear macules on the lower extremities, which fade spontaneously. We present three patients with linearly distributed purpuric macules on only one side of the lower extremities. Skin biopsy showed histopathological features of PPDs. We diagnosed ULC based on these clinicopathological findings. For all patients, the skin lesions began to fade spontaneously within several months to a few years after onset. ULC has been reported rarely, with only about 20 cases worldwide and no cases described in the Korean literature.
Assuntos
Humanos , Biópsia , Extremidade Inferior , Pele , DermatopatiasRESUMO
No abstract available.