The effect of octreotide, a ling-acting somatostatin analogue, on the reduction of mucosal secretion after ileocystoplasty in rats / 대한비뇨기과학회지

The use of isolated intestinal segments is currently the best method of augmenling bladder capacity. Pedicled segments of ileum and colon used in lower urinary tract reconstruction retain their normal neurovascular input and might be expected to retain their physiological function despite their new anatomical situation. The mucus secreted mostly by goblet cells in the grafted intestinal mucosa elicits various problems in patient management. This study was attempted to evaluate the effect of octreotide, a long-acting somatostatin analogue on the mucosal secretion. The animals, weighing 250-320gm, were divided into 2 groups: control group, in which only ileocystoplasty was done, and octreotide injection group after ileocystoplasty. Oclreolide was injected daily S.C. 0.002 micrometer/gm after posloperalive 1 week. Cystectomies were performed at postoperative 1. 2, 3, 4 weeks. Histopathologic examination of the ileocystoplasty specimens was done by light microscopy after PAS reaction. 24-hour urine was collected for each rat weekly and then the amount of lyophilized dry mucus in urine was measured. The number of goblet cells within 10(3) micrometer2 of mucosal epithelium in the grafted ileal segments were evaluated by morphometric analysis using an image analyzer. The results were as follows: 1. Microscopically, transitional epithelium extended well over the intestinal mucosa through the anastomotic site at both 4 weeks groups. 2. The amount of urinary lyophilized dry mucus at control group was increased at postoperative 2. 3 weeks (64.2 mg, 67.7 mg) and decreased at 4 weeks (32.7 mg). After octreotide injection, the amount of lyophilized dry mucus significantly decreased when compared with the control group at 2, 3 weeks (15.2 mg, 18.9 mg, p<0.01) 3. The number of goblet cells within 10(3) micrometer2 of mucosal epithelium in control group was increased at 2. 3 weeks after operation (1.94+/-0.31, 2.19+/-0.36) and decreased at 4 weeks (1.61+/-0.25). After octreotide injection. The number of goblel cells significantly decreased when compared with the control group at 2, 3 weeks (1.28+/-0.36, 1.54+/-0.26, p<0.01). These results suggest that octreotide may be effect on the reduction of mucosal secretion after ileocystoplasty. Further investigation using this method will be needed for clinical application.

A case of collecting duct carcinoma of the kidney / 대한비뇨기과학회지

Collecting duct carcinoma is an unusual variant of renal cell carcinoma, which is originated from the collecting tubules of the kidney. The typical histological appearance is that of a papillary adenocarcinoma with infiltrating tubules and desmoplastic reaction. And there is mainly tubulo-papillary. structure in histologic examination. We report a case of collecting duct carcinoma of kidney in a 47 years old female, which was managed by radical nephrectomy.

A case of retroperitoneal neurilemmoma / 대한비뇨기과학회지

Neurilemmoma is wel1 encapsulated tumor of Schwann cell origin. It is more often solid than cystic and. usually solitary and may be benign. The treatment is surgical excision. We report a 42-year-old man hospitalized with complaints of RUQ pain and palpable mass. There was no endocrinological abnormality. Ultrasonography, computerized tomography and angiography revealed right huge extrarenal mass without metastatic evidence. The patient underwent surgical excision.