Comparison of the clinical efficacy of minimally invasive closed reduction and open reduction and internal fixation for ankle fracture / 中国基层医药

Objective@#To compare the clinical efficacy of minimally invasive closed reduction and open reduction and internal fixation in the treatment of ankle fractures.@*Methods@#133 cases with ankle fractures were selected.They were divided into closed group (65 cases) and incision group (68 cases) according to random table method.The closed group was treated with minimally invasive closed reduction, and the incision group was treated with open reduction and internal fixation.The therapeutic effect, amount of bleeding, time of fracture healing, time of operation and postoperative complications were compared between the two groups.@*Results@#The good rate of the closed group (98.46%) was higher than that of the control group(85.29%, χ2=7.594, P<0.05). The amount of bleeding in the closed group[(19.40±3.56) mL] was less than that in the incision group[(39.84±4.15)mL], the fracture healing time in the closed group[(10.24±2.15)weeks] was shorter than that in the incision group[(15.46±3.67)weeks], the operation time in the closed group[(38.94±8.71)min] was shorter than that the incision group[(59.38±13.25)min](t=30.424, 9.950, 10.462, all P<0.05). The incidence rate of postoperative complication in the closed group (1.54%) was lower than that in the incision group (16.18%, χ2=8.675, P<0.05).@*Conclusion@#Minimally invasive closed reduction in the treatment of ankle fractures is better than open reduction and internal fixation, and has important research value.

Expression of NonO protein during murine erythroleukemia cell differentiation induced by sodium butyrate / 解剖学报

Objective To study NonO protein expression changes in murine erythroleukemia ( MEL ) cell differentiation induced by sodium butyrate .Methods Benzidine staining was used to test sodium butyrate-induced erythroid differentiation of MEL cells .We detected NonO protein expression changes in MEL cell differentiation induced by sodium butyrate and NonO protein localization in MEL cells by Western blotting and immunocytochemistry .Furthermore , we applied PCR technique to detect NonO RNA expression in differentiation process .Results We found that NonO protein was upregulated at gene and protein levels in the erythroid differentiation process of MEL cells induced by sodium butyrate and located in cytoplasm and nucleus in MEL cells .Conclusion These results show that NonO protein is closely related with MEL cell differentiation induced by sodium butyrate , which may provide important clues for further study of the mechanism of leukemia .