RESUMO
<p><b>OBJECTIVE</b>To investigate the effect of an oral preparation of Alternathera philoxeroides Griseb (APG) against respiratory syncytical virus (RSV) in mice.</p><p><b>METHODS</b>APG preparation was administered orally in RSV-infected mice at different daily doses (2.5, 4.5 and 6.5 g/kg) to observe the therapeutic effect of the preparation.</p><p><b>RESULTS</b>Distinct differences were observed between the death rate of the mice treated with APG at daily dose of 4.5 and 6.5 g/kg and that of the untreated mice with infection. After AGP treatment of the mice at 6.5 g/kg, the detection rate of the virus was 31.3% in the blood and 37.5% in the lung tissue, significantly lower than that in the untreated mice. The virus detection rate was 43.8% in the lung tissues of mice treated with APG at 4.5 g/kg, also significantly lower than that in the untreated control. APG treatment at the 3 doses resulted in different lung indices from that of the control.</p><p><b>CONCLUSION</b>APG may be effective for treatment of RSV infection.</p>
Assuntos
Animais , Feminino , Masculino , Camundongos , Administração Oral , Amaranthaceae , Química , Antivirais , Usos Terapêuticos , Relação Dose-Resposta a Droga , Pulmão , Patologia , Virologia , Camundongos Endogâmicos BALB C , Fitoterapia , Preparações de Plantas , Usos Terapêuticos , Distribuição Aleatória , Infecções por Vírus Respiratório Sincicial , Tratamento Farmacológico , Vírus Sinciciais Respiratórios , Resultado do TratamentoRESUMO
<p><b>OBJECTIVE</b>To investigate the association of Coxsackie B virus (CBV) with habitual abortion.</p><p><b>METHODS</b>CBV IgM antibody, viral RNA and virions were detected in 86 women with habitual abortion and 40 with induced abortion by means of enzyme-linked immunosorbent assay (ELISA), RT-PCR and virus isolation, respectively.</p><p><b>RESULTS</b>The positivity rate of CBV IgM were 87.2% and 35% in the two groups, respectively, and the detection rate of the viral RNA was 53.5% and 17.5% in blood lymphocytes, and 59.3% and 17.5% in the placentas. The virions were found in the placentas in 41.9% and 6.9% of the women, respectively. The positivity rates of CBV IgM, viral DNA and virions showed significant difference between the two groups (P<0. 01).</p><p><b>CONCLUSION</b>CBV might be one of the causes responsible for habitual abortion.</p>