RESUMO
Objective To evaluate patient-controlled epidural analgesia (PCEA) with morphine on breastfeeding neonatal neurological arid adaptive capacity after cesarean section.Methods Thirty healthy parturients after cesarean section under epidural block were randomly selected as test group, and thirty healthy parturients with natural childbirth served as control group without any opioids administration. In test group the patients received PCEA after cesarean section. The regimen included a loading dose of morphine 2mg, bupivacaine 12.5mg and droperidol 0.5mg in 10ml of normal saline, followed by background infusion at 2 ml?h~(-1) with an 2ml bolus dose and a 20min lockout interval. The PCEA solution contained morphine 20mg, bupivacaine 125mg and dreporidol 5 mg in 100ml of normal saline. The samples of intravenous blood and colostrums were taken 2, 4, 8,12 and 24 h after the loading dose administration for measurement of plasma and colostrums concentrations of morphine. The neonatal neurological and adaptive capacity scores(NACS) of both groups were recorded at corresponding time points, Results Concentrations of morphine in colostrum and plasma kept decreasing following the loading dose administration. There was a significant positive correlation between concentrations of morphine in colostrum and plasma (r=0.998, P