Relationship between gene mutations and intelligence in children with Duchenne muscular dystrophy / 中国当代儿科杂志

<p><b>OBJECTIVE</b>To study the level of intelligence in children with Duchenne muscular dystrophy (DMD), and the relationship between the level of intelligence and gene mutations.</p><p><b>METHODS</b>One hundred and two children with DMD between January 2009 and March 2011 were enrolled. DMD gene detection was performed through the multiplex ligation-dependent probe amplification (MLPA) in 84 cases. The level and the structure of intelligence were evaluated by Chinese Wechsler Intelligence Scale for Children (C-WISC) in 50 children with DMD (≥6 years old; DMD group) and in 50 age-and gender-matched healthy children (control group).</p><p><b>RESULTS</b>The average intelligence quotient (IQ) was 84±21 in 102 children with DMD. Thirty patients (29.4%) had the full intelligence quotient (FIQ) less than 70. The FIQ, verbal intelligence quotient (VIQ), performance intelligence quotient (PIQ) and the scores of 11 sub-tests of intelligence in the DMD group were significantly lower than those in the control group (P<0.01). The IQ in patients with gene mutations at exon 56-79 was the lowest (59.3±11.9), followed by in patients with gene mutations at exon 45-55 (88.6±1.9), at exon 1-29 (97.5±9.6) and at exon 30-44 (102.8±3.8) (P<0.01).</p><p><b>CONCLUSIONS</b>The FIQ, VIQ and PIQ in children with DMD are lower than those in healthy children. There is association between mental retardation and gene mutations.</p>

Comparative study on sensory integration function in children with primary nocturnal enuresis / 中国当代儿科杂志

<p><b>OBJECTIVE</b>To study the sensory integration function in children with primary nocturnal enuresis (PNE).</p><p><b>METHODS</b>The sensory integration function was assessed by the Childhood Sensory Integration Ability Development Checklist in 70 children with PNE and was compared with that in 74 normal children(control group).</p><p><b>RESULTS</b>The incidence of sensory integration dysfunction (76%) in the PNE group were significantly higher than that in the control group (35%; P<0.01). Severe sensory integration dysfunction occurred in more children in the PNE group compared with the control group (39% vs 18%; P<0.01). The scores of all sensory integration indexes revealed by sensory integration function testing in the PNE group were significantly lower than those in the control group (P<0.01).</p><p><b>CONCLUSIONS</b>The majority of children with PNE have sensory integrative dysfunction which presents in various aspects. It is necessary to assess the sensory integration function in children with PNE.</p>

Gender analysis on prenatal care in rural areas of Xinjiang and Anhui province / 中华流行病学杂志

Objective To introduce the gender-specific view to the prenatal care and analysing the health behavior and its influencing factors. Methods Random sampling in cluster was used to select those study population and face to face interview was carried out at their residence in Xinjiang and Anhui province. Results The overall socioeconomic status of women in rural areas of Xinjiang and Anbui province was low and 93.2% of the women had education level on junior middle school or below. Politically women were less interested in these issues with only 63.1% of them ever participated in the election program or voting. In household daily life, women' s status was almost equal to or even higher than men, but men always called the shots when something important in family happened. Men still held the power of decision making. In 47.3% of the families, the husband played a decisive role on decision making. In 37.7% of the families, husbands controlled the money. When getting into expensive expenditure, 35.2% of the families having men made the final approval. When there were different opinions between the couples, husband usually made the final decision in 44.2% of all the families compared to 6.3% of the families that wives made the final decision. 73.9% of women under survey bad undergone prenatal examination and the rate on household deliveries reached 30.3%. Both gender consciousness and educational level had influenced the effect on prenatal care. Conclusion It is important to better prenatal health service in rural areas and to improve socioeconomic status on gender consciousness of women.

Intelligence level and structure in school age children with fetal growth restriction / 中国当代儿科杂志

<p><b>OBJECTIVE</b>To study the intelligence level and structure in school age children with fetal growth restriction (FGR).</p><p><b>METHODS</b>The intelligence levels were tested by the Wechsler Children Scales of Intelligence (C-WISC) in 54 children with FGR and in 84 normal children.</p><p><b>RESULTS</b>The full intelligence quotient (FIQ), verbal IQ (VIQ) and performance IQ (PIQ) in the FGR group were 105.9+/-10.3, 112.4+/-11.2 and 97.1+/-10.6 respectively, and they all were in a normal range. But the PIQ was significantly lower than that in the control group (104.8+/-10.5; p<0.001), and the picture arrangement and the decipher subtest scores were significantly lower than those in the control group (p<0.01). The scores of perception/organization and memory/attention factors in the FGR group were 99.8+/-11.1 and 116.3+/-14.4, respectively, which were inferior to those in the control group (104.6+/-11.5 and 113.4+/-14.5 respectively; p<0.05).</p><p><b>CONCLUSIONS</b>The total intelligence level of children with FGR is normal, but there are imbalances in the intelligence structure and dysfunctions in performance ability related to right cerebral hemisphere. Performance trainings should be done from the infancy in children with FGR.</p>

Attentiveness in school children: effect of cesarean section birth / 中国当代儿科杂志

<p><b>OBJECTIVE</b>To study the effect of cesarean section birth based on different indications on attentiveness in school children.</p><p><b>METHODS</b>A total of 308 school children were assigned to three groups according to their birth model: natural delivery (n = 105), cesarean section due to social factors (n = 101) or medical factors (n = 102). The integrated visual and auditory continuous performance test (IVA-CPT) was performed for assessing attentiveness.</p><p><b>RESULTS</b>The IVA-CPT demonstrated that there were significant differences in the quotients of combination control, auditory response control, combination attention, auditory attention, visual attention, auditory vigilance, visual concordance, visual vigilance and visual attention among the three groups (p<0.05). The results of the IVA-CPT in the group of cesarean section due to medical factors was obviously poorer than that of the natural delivery group and the group of cesarean section due to social factors. However no significant differences were observed between the groups of natural delivery and of cesarean section due to social factors.</p><p><b>CONCLUSIONS</b>Cesarean section itself has no significant impacts on attentiveness in school children, while medical indications for cesarean section may contribute to major cause of attention deficit disorder.</p>

Study on status of nutrition in children under three years old in rural area in China / 中华流行病学杂志

<p><b>OBJECTIVE</b>To understand the nutrition status of children under three years in rural area of western China and to explore the influencing factors so as to provide reasonable suggestions for policy making.</p><p><b>METHODS</b>Use PPS sampling method to investigate the 13,532 children under three years old. Height and weight were used as nutritional indexes.</p><p><b>RESULTS</b>The prevalence of stunting (height for age Z-score < -2), underweight (weight for age Z-score < -2) and wasting (weight for height Z-score < -2) were 12.4%,11.8% and 5.7% respectively. Boys, minority and the children from western China had higher prevalence rate. The prevalence rates of the Han nationality children's underweight and stunting were 9.5% and 9.8%, but these rates of the minority children were 15.6% and 16.5% respectively, which were obviously higher than the Han ethnicity children with significant differences between them (P <0.01).The prevalence of malnutrition was rising with age and the peak age of stunting, underweight and wasting appeared at 21 months, 12 months and 15 months, respectively. Compared with growth reference of NCHS/WHO, the HAZ, WAZ and WHZ left moved 0.59,0.60 and 0.26 units which indicated the whole nutritional status of children from program area impaired to some extent. Underweight inclined to have higher two-week prevalence rates of diarrhea and flu than in the normal children,achieving 15.9% and 13.5%, but with significant differences between them (P<0.01). We administered non-conditional logistic regression analysis to identify the influencing factors of malnutrition. Under-6-month children who were not taken care by their mothers showed higher risk of stunting. Over-6-month children stunting had significant relationship with age, gender, sibling order, nationality,maternal educational level,special cooking for children and residential region. Underweight of over-6-month children significantly related to age, nationality, and maternal educational level, yolk supply during 6-8 month old and living region.</p><p><b>CONCLUSION</b>Malnutrition was really prevalent among children in China,suggesting that intervention should be done according to the influencing factors.</p>