RESUMO
OBJECTIVE@#To investigate the mechanism of expression and significance of vascular endothelial growth factor (VEGF) and p53 in degenerate intervertebral disc tissue.@*METHODS@#Pathological sections collected from 156 patients with lumbar disc herniation after surgery were tested by immunohistochemistry method, for evaluation of the expression of VEGF and p53 in degenerate intervertebral disc tissue.@*RESULTS@#98 cases (62.8%) with vascular infiltration phenomenon are found, and positive rates of VEGF and p53 in degenerate intervertebral disc tissue are 73.42% (116/156) and 58.97% (92/156); co-expression rate is 53.2%(83/156); the expression rates of VEFG and p53 are significantly higher in the tissue with blood vessel infiltration than in the tissue without infiltration; there is a close relationship of VEGF with p53.@*CONCLUSIONS@#VEGF and p53 gene synergetic express in degenerate intervertebral disc tissue, working together in neovascularization and infiltration, and accelerating intervertebral disc tissue degeneration.
Assuntos
Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos de Casos e Controles , Distribuição de Qui-Quadrado , Imuno-Histoquímica , Disco Intervertebral , Metabolismo , Degeneração do Disco Intervertebral , Metabolismo , Proteína Supressora de Tumor p53 , Fator A de Crescimento do Endotélio Vascular , MetabolismoRESUMO
<p><b>OBJECTIVE</b>To compare the efficiency difference in chronic orchialgia between electroacupuncture and western medicine and explore the better therapy for chronic orchialgia.</p><p><b>METHODS</b>Eighty-six cases of chronic orchialgia were randomly divided into an electroacupuncture group (56 cases) and an Indomethacin group (30 cases). Except the conventional oral administration of Amitriptyline for anti-depression, electroacupuncture was applied at Shenshu (BL 23), Ciliao (BL 32), Sanyinjiao (SP 6), Taichong (LR 3) and others in electroacupuncture group, and Indometacin suppository anal therapy was used in Indometacin group. The session of treatment in two groups was 2 weeks. Before and after treatment, pain number assessment scale was adopted for the assessment of pain severity separately to compare the differences in pain score on 3rd, 7th, 10th and 14th days after treatment.</p><p><b>RESULTS</b>The pain score at each time point was improved remarkably as compared with that before treatment in two groups (P < 0.05, P < 0.01). In comparison on the 7th, 10th and 14th days of two groups, the pain scores in electroacupuncture group was lower than those in Indometacin group (all P < 0.05).</p><p><b>CONCLUSION</b>Electroacupuncture combined with Amitriptyline treatment is quite effective on chronic orchialgia, which is superior to the effect of Indo methacin combined with Amitriptyline treatment and deserves to be promoted in application.</p>