High-resolution cellular traction force recovery in two dimensional Fourier domain / 医用生物力学

Objective To develop a new set of algorithms for high-resolution cellular traction force recovery based on two-dimensional Fourier domain by addressing the ill-posed nature of classic cellular force traction recovery. Methods By exploring the inherent characteristics and rules of displacement data on the substrates and Green’s function in the Fourier domain, the phenomenon of ill-posed deconvolution arising in cellular force traction recovery was investigated and a set of self-adaptive filtering algorithms was consequently developed to remarkably restrain the high frequency noise amplification. Results The ill-posed nature of classical Fourier transform traction cytometry (FTTC) made cellular traction force recovery extremely unstable, especially for relatively dense displacement data sampling. In contrast, the proposed self-adaptive filtering algorithms based on FTTC could make cellular traction force distribution more stable and reliable, as the effect of high frequency noise in displacement field on recovery results was weakened significantly. Conclusions This new technique for cellular traction force recovery can effectively suppress the noise and therefore improve the stability of force recovery procedure and spatial resolution, which is expected to find wider application in the study of cell substrate interactions.

B-type natriuretic peptides and subclinical target organ damage in essential hypertensive patients / 南方医科大学学报

<p><b>OBJECTIVE</b>To investigate the relationship between B-type natriuretic peptides (BNP) and subclinical target organ damage in essential hypertensive (EH) patients.</p><p><b>METHODS</b>A total of 317 EH patients were divided into 3 groups according to BNP levels, namely normal (BNP<600 ng/L) group (n=102), moderate (600-883.5 ng/L) group (n=116), and elevated BNP (>883.5 ng/L) group (n=99). The blood pressure, left ventricular mass index (LVMI), the intima media thickness (IMT) of the common carotid artery, the plaque size in the coronary artery (CS) and microalbuminuria levels were analyzed in these patients.</p><p><b>RESULTS</b>The EH patients with moderate and elevated BNP showed significantly higher LVMI, IMT, CS and microalbuminuria levels than those with normal BNP level (LVMI: 102.8∓23.12 and 123.9∓26.47 vs 91.09∓18.71 g/m2; IMT: 0.95∓0.32 and 1.16∓0.37 vs 0.84∓0.28 mm; microalbuminuria: 31.36∓20.55 and 36.73∓22.07 vs 23.21∓18.68, P<0.01). After adjustment, BNP was positively correlated to LVMI, IMT, CS and microalbuminuria level (r=0.45, 0.43, 0.39 and 0.41, respectively, P<0.01). Multivariate logistic regression analysis showed that age, systolic blood pressure, BNP, FPG, and microalbuminuria, LDL-C, and BMI were all related to the occurrence of subclinical target organ damages.</p><p><b>CONCLUSION</b>BNP is positively correlated to subclinical target organs damages in EH patients.</p>

Comparison of bisoprolol and carvidilol in antihypertensive effects and reversing left ventricular hypertrophy in patients with essential hypertension / 中国基层医药

Objective To investigate the effects of antihypertension and reversing left ventricular hypertro- phy by carvedilol or bisoprolol in patients with mild to moderate essential hypertension.Methods 40 cases of mild to moderate essential hypertension patients were selected for this random single-blind,paralleling controlled clinical study.Results Patients were randomized to take 12.5～25mg carvedilol tablet orlce daily or bisoprolol 2.5～5mg once daily if DBP was still in the range of 12.0～14.6kPa(90～110mmHg)after 2 weeks' placebo baseline. Carvedilol group included 20 cases,bisoprolol group included 20 cases,and the course was 24 weeks.Blood pressure and heart rate were measured and symptoms and signs were recorded.At the end of placebo and in 24 weeks heart ultrasound,blood routine,serum glucose,blood lipid,hepatic function and renal function were examined.SBP,DBP and heart rate of patients in two groups decreased obviously.There were significant differences between the two groups.Ventricular hypertrophy of carvedilol group improved than that in pretherapy.There were significant differ- ences between the two groups.Conclusion Carvedilol was well-tolerated with less side effects such as mild headache,tiredness,dizziness,slightly elevating of serum glucose.Carvedilol could well treat the mild moderate essen- tial hypertension effectively and safely by 12.5～25mg once daily.