RESUMO
Autoimmune disease refers to a series of diseases caused by the body's immune response to autoantigens leading to autologous tissue damage. The examples include rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and psoriasis, etc. Janus kinases (JAKs) are a class of non-receptor tyrosine kinases that are essential signaling mediators in the signal transduction and expression of the inflammatory cytokines, which are closely related to the occurrence and development of the autoimmune diseases. Studies have shown that the inhibitors targeting JAK can exert anti-inflammatory and immuno-modulatory pharmacological activities by modulation of the cell signaling pathways related to the inflammatory cytokines. In this paper, the literature about small-molecule drugs targeting JAK on autoimmune diseases in recent years are summarized to provide valuable information for the research and development of drugs.
RESUMO
The ulcerative colitis is closely related to colitis associated cancer.The main mechanisms related to the occurrence,development and malignant transformation of CAC includes NF-κB pathway,signal transducers and ac-tivator of transcription(STAT) and related protein pathways,intestinal microflora imbalance,the immune microen-vironment,Toll-like receptor (TLR)-related pathway and so on.