Diagnosis and treatment of esthesioneuroblastoma in the nasal cavity and sinuses / 南方医科大学学报

<p><b>OBJECTIVE</b>To discuss the clinical characteristics, diagnosis and treatment of esthesioneuroblastoma (ENB).</p><p><b>METHODS</b>The clinical data of 7 patients with ENB were analyzed retrospectively, and the clinical characteristics, diagnosis, surgical approaches and prognosis of the disease were discussed.</p><p><b>RESULTS</b>The 7 patients received surgical treatment combined with radiotherapy and chemotherapy. Tumor relapse occurred within one year in two cases, which were treated with a second operation combined with radiotherapy, and one patient died and one survived with tumor after a one-year follow-up.</p><p><b>CONCLUSION</b>Early diagnosis of ENB can be difficult. Transnasal-frontal approach with nasal endoscope is effective approach to ENB treatment, and the patients may benefit from postoperative radiotherapy and chemotherapy to improve the prognosis.</p>

Mastoid surgery for secretory otitis media with mixed hearing loss / 南方医科大学学报

<p><b>OBJECTIVE</b>To analyze the therapeutic effect of mastoid surgery for secretory otitis media with mixed hearing loss.</p><p><b>METHODS</b>A retrospective analysis was conducted of the data from 26 cases (43 ears) of secretory otitis media with bone conduction hearing loss collected from 2001 to 2008. Thirty-two ears were treated with mastoid surgery and myringotomy with insertion of ventilation tubes. All the patients received medications after the operation.</p><p><b>RESULTS</b>All the patients showed obvious improvement after mastoid surgery. The average pure tone of air conduction hearing threshold was about 25 dB after the surgery, with the average pure tone of bone conduction hearing threshold of about 15 dB. The patients were followed up for 1-2 years during which no significant change in hearing was recorded, and no middle ear effusion in the tympanic cavity was found after removal of the ventilation tubes.</p><p><b>CONCLUSION</b>Persistent secretory otitis media can be associated with mixed hearing loss, and mastoid surgery can significantly enhance the hearing level to produce positive therapeutic effects.</p>