Activation of periphery group III metabotropic glutamate receptors inhibits formalin-induced activation of spinal p38-MAPK in rats / 中国应用生理学杂志

<p><b>AIM</b>To explore the effects of periphery injection of L-SOP on the activation of p38MAPK in spinal cord in formalin pain model in rats.</p><p><b>METHODS</b>Fourty-eight male Wistar rats were divided randomly into four groups (n=12): NS group and three different dose of L-SOP groups. For each group, 6 rats used to observe flinching and licking time every as nociception behavior 3 minutes in 1 hour after formalin injected and the other 6 rats used to observe the activation of p38(P-p38) by Western blotting.</p><p><b>RESULTS</b>All the three different groups of L-SOP could inhibit nociception behavior in the tonic phase,and 250 nmoVl/L and 500 nmol/L groups could suppress not only in the tonic phase but also in the acute phase. 250 nmol/L and 500 nmol/L groups could reduce activated or phosphorylated p38MAPK in spinal cord.</p><p><b>CONCLUSION</b>Periphery injection of L-SOP can reduce nociceptive behavior and phosphorylated p38MAPK in the spinal cord in formalin-induced hyperalgia, it is suggested that there is functional expression of mGluRs III in the periphery and is involved in the processing of peripheral noxious informations.</p>

Observation on therapeutic effect of electroacupuncture plus blood-letting puncture at Weizhong (BL 40) on acute lumbar disc herniation / 中国针灸

<p><b>OBJECTIVE</b>To find a better method for treatment of acute lumbar disc herniation.</p><p><b>METHODS</b>One hundred cases were randomly divided into 2 groups. The observation group of 52 cases was treated with electroacupuncture at Yaoyangguan (GV 3), Dachangshu (BL 25), Guanyuanshu (BL 26), Xiaochangshu (BI. 27) as main points, and blood-letting puncture at stagnant collaterals nearby Weizhong (BL 40); the control group of 48 cases was treated with traction combined with electroacupuncture at main points Jiaji (EX-B 2), Shenshu (BL 23), Dachangshu (BL 25). Their therapeutic effects were observed and compared.</p><p><b>RESULTS</b>The cured rate and the cured markedly effective rate were 55.8% and 82.7% in the observation group and 33.3% and 54.2% in the control group, respectively, with significant differences between the two groups (P < 0.05, P < 0.01).</p><p><b>CONCLUSION</b>Electroacupuncture combined with blood letting puncture at stagnant collaterals nearby Weizhong (BL 40) has a signifi cant therapeutic effect on acute lumbar disc herniation.</p>