Research advances in association between diseases outside the gallbladder and gallstones / 临床肝胆病杂志

Gallstones is a common digestive system disease in China and has a complex pathogenesis. It is often considered that it is mediated by many factors in the genetic background, including biliary cholesterol supersaturation, intestinal cholesterol hyperabsorption, abnormal cholesterol nucleation in bile, dysfunction in gallbladder dynamics, and cholestasis. This article reviews the role of the above mechanisms in the association between diseases outside the gallbladder and gallstones. Based on current evidence, the above diseases may promote the formation of gallstones, and active intervention of the above diseases outside the gallbladder may help to expand new strategies for the prevention and treatment of gallstones.