Mechanism of Protective Effect of Grape Seed Procyanidin Extract on Model Rats with Acetic Acid-induced Colitis / 中国药房

OBJECTIVE:To study the mechanism of action of grape seed proanthocynidins extract(GSPE)in treating acetic acid-induced colitis gravis in rats.METHODS:Rats model with acetic acid-induced colitis was built,the animals were di-vided into normal control group,model group,positive control group and GSPE group(which were subdivided into low,medium and high dose subgroups by intragastric administration).On the8th day of administration of drugs,the changes of myeloperoxidase(MPO),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)and malonaldehyde(MDA)in colonic tissue were detected,respectively.RESULTS:The model group had a significantly higher level of MPO content than did the normal control group(P