A predictive model of lymph node metastasis after thoracoscopic surgery for lung adenocarcinoma with a diameter≤3 cm / 中国胸心血管外科临床杂志

@#Objective    To predict the probability of lymph node metastasis after thoracoscopic surgery in patients with lung adenocarcinoma based on nomogram. Methods    We analyzed the clinical data of the patients with lung adenocarcinoma treated in the department of thoracic surgery of our hospital from June 2018 to May 2021. The patients were randomly divided into a training group and a validation group. The variables that may affect the lymph node metastasis of lung adenocarcinoma were screened out by univariate logistic regression, and then the clinical prediction model was constructed by multivariate logistic regression. The nomogram was used to show the model visually, the receiver operating characteristic (ROC) curve, calibration curve and clinical decision curve to evaluate the calibration degree and practicability of the model. Results    Finally 249 patients were collected, including 117 males aged 53.15±13.95 years and 132 females aged 47.36±13.10 years. There were 180 patients in the training group, and 69 patients in the validation group. There was a significant correlation between the 6 clinicopathological characteristics and lymph node metastasis of lung adenocarcinoma in the univariate logistic regression. The area under the ROC curve in the training group was 0.863, suggesting the ability to distinguish lymph node metastasis, which was confirmed in the validation group (area under the ROC curve was 0.847). The nomogram and clinical decision curve also performed well in the follow-up analysis, which proved its potential clinical value. Conclusion    This study provides a nomogram combined with clinicopathological characteristics, which can be used to predict the risk of lymph node metastasis in patients with lung adenocarcinoma with a diameter≤3 cm.

Exploration of CT imaging features of cystic pulmonary nodules and establishment of a prediction model for benign and malignant pulmonary nodules / 中国胸心血管外科临床杂志

@#Objective To explore the CT imaging features and independent risk factors for cystic pulmonary nodules and establish a malignant probability prediction model. Methods The patients with cystic pulmonary nodules admitted to the Department of Thoracic Surgery of the First People's Hospital of Neijiang from January 2017 to February 2022 were retrospectively enrolled. They were divided into a malignant group and a benign group according to the pathological results. The clinical data and preoperative chest CT imaging features of the two groups were collected, and the independent risk factors for malignant cystic pulmonary nodules were screened out by logistic regression analysis, so as to establish a prediction model for benign and malignant cystic pulmonary nodules. Results A total of 107 patients were enrolled. There were 76 patients in the malignant group, including 36 males and 40 females, with an average age of 59.65±11.74 years. There were 31 patients in the benign group, including 16 males and 15 females, with an average age of 58.96±13.91 years. Multivariate logistic analysis showed that the special CT imaging features such as cystic wall nodules [OR=3.538, 95%CI (1.231, 10.164), P=0.019], short burrs [OR=4.106, 95%CI (1.454, 11.598), P=0.008], cystic wall morphology [OR=6.978, 95%CI (2.374, 20.505), P<0.001], and the number of cysts [OR=4.179, 95%CI (1.438, 12.146), P=0.009] were independent risk factors for cystic lung cancer. A prediction model was established: P=ex/(1+ex), X=–2.453+1.264×cystic wall nodules+1.412×short burrs+1.943×cystic wall morphology+1.430×the number of cysts. The area under the receiver operating charateristic curve was 0.830, the sensitivity was 82.9%, and the specificity was 74.2%. Conclusion Cystic wall nodules, short burrs, cystic wall morphology, and the number of cysts are the independent risk factors for cystic lung cancer, and the established prediction model can be used as a screening method for cystic pulmonary nodules.

Conditions for the determination of intrinsic uniformity and intrinsic spatial linearity of SPECT / 中国辐射卫生

Objective To address the absence of matrix specified for the determination of intrinsic uniformity in the current standard, and to investigate the effect of source distances on intrinsic spatial linearity, the intrinsic uniformity and intrinsic spatial linearity of 16 probes in eight SPECT devices were measured and analyzed with different matrices and source distances, in order to determine the optimal measurement conditions. Methods According to the standard Specification for Testing of Quality Control in Gamma Cameras and Single Photon Emission Computed Tomograph (SPECT) (WS 523—2019), the intrinsic uniformity was measured using 64 × 64 and 256 × 256 matrices and the intrinsic spatial linearity was measured using of 1.7 and 3 m source distances. Results When intrinsic uniformity was measured with the 64 × 64 matrix, more than 50% of the probes showed lower values. When intrinsic spatial linearity was measured with the 3 m source distance, more probes showed lower values. Conclusion The 64 × 64 matrix is recommended for the determination of intrinsic uniformity and a source distance of ＞5 FOV is recommended for the measurement of intrinsic spatial linearity.

Measurement of thyroid 131I activity in 162 iodine treatment workers in Hubei Province, China / 中国辐射卫生

Objective To determine the current status of occupational internal exposure to 131I in the thyroid of nuclear medicine workers, to explore the influencing factors for internal exposure, and to provide a basis for the radiation safety management of nuclear medicine. Methods The cluster sampling method was used to select 162 workers practicing 131I treatment in 24 hospitals in Hubei Province, China. Thyroid 131I activity levels were measured in vitro using a portable γ-spectrometer, and the committed effective dose was estimated. Results The thyroid 131I activity detected in 13 (54.17%) hospitals was above the lower limit of detection of the instrument. Two hospitals had the highest detection rates, 62.50% and 61.90%; the difference was significant compared with the remaining 11 hospitals (P < 0.0001). Thyroid 131I was detected in 34 workers in total, with a detection rate of 20.99% and a mean activity of 179.09 ± 138.71 (6.02-589.74) Bq. The highest detection rates were found in cleaners and nurses, which were 35.71% and 33.33%, respectively, with no significant difference in detection rate between positions (least P > 0.08). The mean value of the committed effective dose was 0.68 ± 0.52 (0.02-2.22) mSv/a in the 34 workers. Conclusion The 131I consumption and workplace ventilation may be important factors affecting the level of internal exposure. It is important to strengthen the training of nuclear medicine workers on radioprotection and workflow management, as well as the regular monitoring of occupational internal exposure for 131I treatment-related workers.

Psychological impact of nuclear accidents on specific populations / 中国辐射卫生

The purpose of establishing nuclear power plants is to meet the growing energy demand. Unfortunately, there have been five major nuclear accidents in history, which have diverse and lasting effects on individuals and society. The well-known health effects are tissue reactions caused by high radiation doses and carcinogenic effects of low radiation doses. In recent years, studies on adult residents, mothers with young children, and clean-up/decontamination workers exposed to high doses of radiation in the areas affected by nuclear power plant accidents show long-term impacts on the mental health of these people. This paper reviews these psychological impacts.

Investigation on awareness of radon and health risks in non-uranium miners from 2020 to 2021 / 中华放射医学与防护杂志

Objective:To understand the non-uranium miners′ awareness of radon and health risks in China and analyze the relevant influencing factors, in order to provide research basis for radiological protection institutions and employers to carry out radon health education.Methods:Male miners in 32 typical non-uranium mines from 11 provinces were selected by using cluster random sampling method from June 2020 to December 2021. The awareness of radon and health risks was investigated, and the influencing factors were analyzed by binary logistic regression model.Results:A total of 1 184 non-uranium miners were investigated, and the radon awareness rate of them was 19.17%. 36.56% of the non-uranium miners heard about radon knew the radon health risks accurately, and 18.06% could identify the measures to reduce radon concentration correctly. Univariate analysis showed that the radon awareness rate of non-uranium miners varied with different education levels, labor relations, post categories, and regions ( χ2=55.92, 21.89, 64.31, 11.26, P<0.05 ). The result of logistic regression analysis showed that a bachelor degree or above, regular employee, administrative personnel and technical personnel were influencing factors of the radon awareness level ( χ2=12.81, 6.58, 5.66, 21.44, P<0.05 ). There was no statistically significant difference of radon awareness rate in different ages, working years, regions, and smoke groups ( P>0.05 ). Conclusions:The awareness level of radon and health risks of non-uranium miners was relatively low in China. Radiological protection institutions and employers should strengthen education and training of radon related knowledge in non-uranium miners through mass media, on-duty training, contract notification and workplace publicity board notification, so as to improve their personal protection consciousness.

The investigation and analysis of eye lens dose to interventional radiology workers in China from 2019 to 2021 / 中华放射医学与防护杂志

Objective:To investigate and analyze the eye lens dose to interventional radiology workers in China from 2019 to 2021.Methods:The monitoring data on eye lens dose to interventional radiology workers from 31 province-level units during 2019-2021 were collected through the National Radiological Health Information Platform. The eye lens dose evaluation indicator was Hp(3), with each monitoring period of no more than 3 months. Kusall-Wallis H test was used for the comparison of multiple groups and pairwise. Results:A total of 6 643 interventional radiology workers were investigated from 2019 to 2021. The average annual eye lens dose was 1.03 mSv, with the median of 0.17 mSv and the maximum of 94.88 mSv. The annual eye lens dose to 59 workers exceeded 20 mSv. It was also found that the annual eye lens dose to the doctors in 2019 and 2020 was slightly higher than that to nurses (rank mean difference=118.29, 129.71, P<0.01), and the lens dose to interventional radiology workers who performed cardiac interventions in 2019 was higher than that to workers who performed peripheral vascular interventions (rank mean difference=46.52, P<0.05). Conclusions:The lens dose to interventional radiology workers is lower than the limits given in Chinese national standard currently in effect, but exceed the latest internationally recommended limit for a few ones. In order to protect the occupational health of interventional radiology workers, the monitoring of lens dose should be strengthened.

Chinese expert consensus on diagnosis, treatment and prevention of venous thrombus embolism associated with chest trauma (2022 version) / 中华创伤杂志

Chest trauma is one of the most common injuries. Venous thromboembolism (VTE) as a common complication of chest trauma seriously affects the quality of patients′ life and even leads to death. Although there are some consensus and guidelines on the prevention and treatment of VTE at home and abroad, the current literatures lack specificity considering the diagnosis, treatment and prevention of VTE in patients with chest trauma have their own characteristics, especially for those with blunt trauma. Accordingly, China Chest Injury Research Society and editorial board of Chinese Journal of Traumatology organized relevant domestic experts to jointly formulate the Chinese expert consensus on the diagnosis, treatment and prevention of chest trauma venous thromboembolism associated with chest trauma (2022 version). This consensus provides expert recommendations of different levels as academic guidance in terms of the characteristics, clinical manifestations, risk assessment, diagnosis, treatment, and prevention of chest trauma-related VTE, so as to offer a reference for clinical application.

Measurement of 131I activity in thyroid of workers at the place of radioiodine therapy in six hospitals / 中华放射医学与防护杂志

Objective:To investigate 131I activity in thyroid of workers at the place of radioiodine therapy and its main influencing factors. Methods:In terms of the types of hospitals, six hospitals that performed radioiodine therapy procedure were selected by quota sampling in the provinces of Shandong and Shanxi. 131I activity in thyroids of 76 workers at the place of radioiodine therapy was measured directly, and their internal doses were estimated. Results:131I activity in thyroids was found to be above the detection limit for 29 subjects (38.16%) in five hospitals. The maximum value of 131I activity was 2 468.45 Bq for a doctor who was responsible for manual distribution of radioisotopes. In general 131I activities in thyroid of workers at the place of radioiodine therapy of six hospitals were not significantly different ( P>0.05). But the measurement result in the hospitals where radioiodine was distributed manually were significantly higher than that in the hospitals where radioiodine was distributed automatically ( Z=1.75, P<0.01). Thyroid measurement result of 12 workers in two hospitals where radioiodine was distributed manually were all above the detection limit, with medians of 324.59 Bq and 331.98 Bq, respectively. The medians of 131I activities in thyroid of 12 staff in the remaining 4 hospitals were all below the detection limit. The detection frequencies of 131I above dose limit were 32.61%, 25.00%, 10.00% and 0. The measurement result for the doctors who participated in distributing 131I and the relevent cleaners were significantly higher than for the doctors who did not participate in distributing 131I at the same hospital ( Z=2.44, 2.12, P<0.05). Conclusions:There was a significant difference in the internal exposure level among workers at the different places of radioiodine therapy. Using automatic loading device could reduce the internal exposure level of the workers at the place of radioiodine therapy. It is necessary to strengthen the radiological protection for workers at the control area of the place of radioiodine therapy.

Analysis of abnormal dose values from individual dose monitoring for radiation workers in medical institutions in China in 2020 / 中华放射医学与防护杂志

Objective:To analyze distributions of dose range, occupational category, and causes of abnormal dose values from individual dose monitoring of radiation workers and to provide recommendations for improving the quality of individual monitoring data and occupational health management in medical institutions.Methods:The data of individual dose monitoring result exceeding 1.25 mSv in a single monitoring cycle, collected by Occupational Health System for Radiology Facilities’ on National Radiological Health Information Platform, was analyzed.Results:A total of 1 113 abnormal dose values were detected in 31 provinces in 2020, with an abnormal rate of 2.48‰, of which workers of diagnostic radiology and interventional radiology accounted for 68.01% and 18.78%, respectively. The dose distribution of abnormal dose values was mainly between 1.25 and 5 mSv. The abnormal dose values were mainly caused by improperly wearing or using personal dosimeters, accounting for 63.88%. Workers for whom the dose values was abnormal due to increased workload accounted for 12.32%, with an average annual individual dose of 5.14 mSv. There was no statistically significant difference in annual individual dose among radiation workers between different occupational groups( P>0.05). Conclusions:Education and training on radiation protection for radiation workers should be strengthened, and a specific and feasible system for radiation protection management, as well as a reward and punishment system, should be established in order to reduce the occurance of the improper wearing of personal dosimeters. Great attention should be paid to occupational exposure of workers in diagnostic radiology and interventional radiology, and a work shift system should be conducted to reduce individual dose levels. It is recommended that standard verification procedures for abnormal dose values from individual dose monitoring should be developed to improve the quality of individual monitoring data.

Herb-drug interaction in the protective effect of Alpinia officinarum against gastric injury induced by indomethacin based on pharmacokinetic,tissue distribution and excretion studies in rats / 药物分析学报

Alpinia officinarum Hance of the Chinese traditional herb for the treatment of emesis,abdominal pain and diarrhea has been used to counteract gastric disease induced by indomethacin in rats without obvious side effects.However,the role of herb-drug interaction between indomethacin and A.officinarum based on pharmacokinetic,tissue distribution and excretion still remains unknown.In this study,an ultra-fast liquid-tandem mass spectrometry(UFLC-MS/MS)method was developed for simultaneous determina-tion of indomethacin and its three metabolites,O-desmethylindomethacin(ODI),deschlor-obenzoylindomethacin(NDI)and indomethacin acyl-β-D-glucuronide(IDAβG)by oral administration of indomethacin solution with and without the ethanolic extract of A.officinarum and applied to comparative pharmacokinetic,tissue distribution and excretion studies.Our results clarified that oral administration of A.officinarum produced significant alterations in the pharmacokinetic parameters of indomethacin.And the pharmacokinetic interaction between indomethacin and A.officinarum reduced the systemic exposure of indomethacin and increased its elimination.Tissue distribution results demonstrated that co-administration of A.Officinarum could not reduce the accumulation of indo-methacin in the target tissue of the stomach,but could accelerate the excretions of indomethacin and its three metabolites including ODI,NDI and IDAβG in the bile and feces of rats in the excretion study.Therefore,A.Officinarum might have a gastrointestinal protective effect through the interaction role with indomethacin based on the pharmacokinetics and excretion in rats.

Standard interpretation of radiological protection requirements for the production places of rare earths / 中国辐射卫生

Chinese national standard GBZ139—2019 Radiological Protection Requirements for the Production Places of Rare Earths was published to replace GBZ 139—2002 Radiological Protection standards for the production places of rare-earth elements and implemented from April 1, 2020. Herein, background on which the new standard was based, the main modifications and the foundations were explained. More specific requirements for the production places of rare earths were stipulated in the new standard, which will play an important role in occupational health protection of the workers engaged in the mining, mineral processing and smelting of rare earths.

Correlation between cognition on hearing protection and mental health status among noise-exposed workers / 中国职业医学

OBJECTIVE: To explore the correlation between the cognition on hearing protection and mental health status of noise-exposed workers. METHODS: A total of 499 noise-exposed workers from 3 enterprises of coal mine, steel and textile in Xinjiang region were selected as study subjects by stratified cluster random sampling method. The cognitive status of hearing protection and mental health status of each group were investigated by the Workplace Health Promotion Pilot Project Questionnaire. RESULTS: A total of 235 workers had abnormal mental health status.The abnormal rate of mental health status was 47.1%(235/499). The results of logistic regression analysis showed that female, age ≤40.0 years, unable to bear current noise hazards, worried about noise-induced-deafness and noise-induced discomfort were the risk factors of abnormality of mental health status(odds ratio values were 1.62, 1.87, 2.42, 2.20, 2.14, P<0.05). Using hearing protectors for ≥3.0 years was the protective factor of abnormality of mental health status(odds ratio value was 0.47, P<0.05). CONCLUSION: The subjective cognition on hearing protection has an impact on the mental health of noise-exposed workers.

Result analysis of occupational health monitoring on radiation workers in national medical institutions in 2018 / 中国职业医学

OBJECTIVE: To analyze the results of occupational health monitoring on radiation workers in national medical institutions in 2018. METHODS: Through the National Radiation Health Information Platform Subsystem Occupational Radiation Diseases and Occupational Health Monitoring System, the monitoring data including the overview of radiological diagnosis and treatment institutions, occupational health management, and occupational health examination information across the country were collected for analysis in 2018. RESULTS: In 2018, there were a total of 55 902 radiological diagnosis and treatment institutions with 353 141 radiation workers nationwide. The radiation dose monitoring rate on individuals and hospitals was 94.6%(334 222/353 141) and 97.3%(91 051/93 559), respectively. The rate of health examination was 84.6%(298 914/353 141) and 95.4%(87 031/91 244) respectively.The monitoring rate on chromosomal aberration in peripheral blood lymphocytes was 0.3% in radiation workers. The rate of opacity under the posterior lens capsule was 4.3% and the rate of thyroid nodules was 25.7% in interventional radiology and nuclear medicine workers. CONCLUSION:s The personal dose monitoring rate and occupational health examination rate of radiation workers in medical institutions in China are maintained at a relatively high level. However, monitoring attention should also be paid to the analysis of chromosome aberrations in peripheral blood lymphocytes, the examination of eye lens and thyroid gland.

Allocation of radiation protection equipment and status of occupational health management for radiation workers in investigated hospitals nationwide in 2019 / 中华放射医学与防护杂志

Objective:To investigate the allocation of radiation protection equipment and status of radiological protection management for radiation workers in hospitals nationwide.Methods:A descriptive analysis was conducted of the data reported from the investigated hospitals based the data for 2019 available from the National Radiological Health Information Platform.Results:A total of 3 806 hospitals were investigated in 2019, including 609 tertiary hospitals, 1 421 secondary hospitals, 1 776 primary and ungraded hospitals. Large differences had been shown in the number of radiation workers in different grade hospitals. The average number of radiation workers were found to be, respectively, 99 in tertiary hospitals, 19 in secondary hospitals, 2 in primary and/or ungraded hospitals. Interventional radiology and nuclear medicine workers were equipped seperately with 0.40 and 0.43 pieces of lead apron, 0.27 and 0.31 lead caps, 0.38 and 0.45 lead rubber neck sleeves, 0.18 and 0.08 pairs of lead rubber gloves and 0.31 and 0.22 pairs of lead glasses. No personal alarming dosimeter was available in 15.25% hospitals where radiotherapy was performed, nor radiation surveillance meter in 27.90% such hospitals. In the hospitals considered, 88.13% workers were granted the Radiation Worker Cetificate and 83.69% received the on-the-job radiation protection training. The number of monitored workers accounted for 99.20%, of which 0.40% received the personal annual dose Hp(10)≥20 mSv. The occupational health surveillance files that had been completed reached 98.05% of the total and the on-the-job radiation workers who had passed the occupational health examination made up to 96.00%. It was advised that, of 76 627 radiation workers who received the 2019 health examination, 0.88% should get out of radiation work for the being time and 0.11% should not continue for this work. Conclusions:The considerably large proportion of radiation workers in China have received individual dose monitoring and occupational health examination. Radiological diagnosis and therapy departments should enlarge the allocation of radiation monitoring and personal protection equipment for radiaton workers in their hospitals.

Research progress on the effect of microplastics on human health / 公共卫生与预防医学

Microplastics refer to plastic particles with a diameter of less than 5 mm. Because of their wide distribution in the environment, it has gradually become one of the environmental hot issues of global concern in recent years. Microplastics are characterized by small particle size and strong adsorption. Existing studies have confirmed the biotoxic effects of microplastics in marine organisms and in experimental animals, suggesting their potential harm to human health. However, there have been few studies on the effects of microplastics on human health, and the research results have been inconsistent. Therefore, by summarizing the recent domestic and foreign studies about human exposure to microplastics as well as their potential effects on human body, this paper provides ideas and theoretical basis for further exploring the effects of microplastics on human health and related mechanisms.

Introduction to national occupational radiation disease reporting system / 中华放射医学与防护杂志

Objective To establish the national occupational radiation disease reporting system and learn about the incidence of occupational radiation sickness in radiation workers. Methods In accordance with the relevant regulations, standards and literatures available in China, the system was designed and implemented to survey the requirements of diagnosis institutions of occupational radiation sickness and administrative departments. Results The system was initially established with expectant functions. The system functional modules consisted of case reporting, case information enquiry, statistical analysis and system management. The diagnosis institutions of occupational radiation sickness had used the system to report the cases diagnosed in 2017. Conclusions The system achieved the standardized case reporting for the institutions of occupational radiation sickness, and provided scientific data for the health surveillance of radiation workers and decisions of governments.

Construction and preliminary application of occupational radiation disease and occupational health monitoring system in China / 中华放射医学与防护杂志

Objective To develop occupational radiation disease and occupational health monitoring system for radiation workers in order to identify the current status of occupational health management of radiation workers in China. Methods In compliance with the relevant laws, regulations and standards in China, the system design was completed according to wide variety of needs. Results An occupational health monitoring system for radiation workers was initially established. The system consisted of four modules and three levels of users to make sure. Conclusions Through the collection of data, some key risk points existing in radiology diagnosis and treatment have been identified in relation to occupational radiation disease, so as to provide scientific basis for health administrative department to carry out decision-making and revision of laws and regulations.

Introduction to national occupational radiation disease reporting system / 中华放射医学与防护杂志

Objective@#To establish the national occupational radiation disease reporting system and learn about the incidence of occupational radiation sickness in radiation workers.@*Methods@#In accordance with the relevant regulations, standards and literatures available in China, the system was designed and implemented to survey the requirements of diagnosis institutions of occupational radiation sickness and administrative departments.@*Results@#The system was initially established with expectant functions. The system functional modules consisted of case reporting, case information enquiry, statistical analysis and system management. The diagnosis institutions of occupational radiation sickness had used the system to report the cases diagnosed in 2017.@*Conclusions@#The system achieved the standardized case reporting for the institutions of occupational radiation sickness, and provided scientific data for the health surveillance of radiation workers and decisions of governments.

Construction and preliminary application of occupational radiation disease and occupational health monitoring system in China / 中华放射医学与防护杂志

Objective@#To develop occupational radiation disease and occupational health monitoring system for radiation workers in order to identify the current status of occupational health management of radiation workers in China.@*Methods@#In compliance with the relevant laws, regulations and standards in China, the system design was completed according to wide variety of needs.@*Results@#An occupational health monitoring system for radiation workers was initially established. The system consisted of four modules and three levels of users to make sure.@*Conclusions@#Through the collection of data, some key risk points existing in radiology diagnosis and treatment have been identified in relation to occupational radiation disease, so as to provide scientific basis for health administrative department to carry out decision-making and revision of laws and regulations.