Effects of compatibility of Schisandra chinensis on Psoralea corylifolia -induced oxidative damage and endoplasmic reticulum stress in hepatocytes / 中国药房

OBJECTIVE To study the effects of the compatibility of Schisandra chinensis on Psoralea corylifolia -induced oxidative damage and endoplasmic reticulum stress in L 02 hepatocytes，and to provide reference for clinical use of the compatibility attenuation of P. corylifolia -S. chinensis . METHODS L02 cells were divided into blank control group ，P. corylifolia model group （1 200 μg/mL P. corylifolia ，calculated by crude drug ），P. corylifolia -S. chinensis low-dose，medium-dose and high-dose groups （1 200 μg/mL P. corylifolia combined with 600，1 200，2 400 μg/mL S. chinensis ，respectively，calculated by crude drug ）. After the cells in each group were cultured in culture medium or drug solution for 48 hours，the levels of aspartate aminotransferase（AST）and alanine aminotransferase （ALT）were detected ；the levels of glutathione （GSH），superoxide dismutase （SOD）and malondialdehyde （MDA）in cell culture medium were detected ；reactive oxygen species （ROS）level and mitochondrial membrane potential in cells were detected ；mRNA and protein expressions of glucose-regulated protein 78（GRP-78）and protein kinase R-like endoplasmic reticulum kinase （PERK）were detected. RESULTS Compared with blank control group ，the levels of AST，ALT，MDA and ROS ，mRNA and protein expressions of GRP- 78 and PERK were increased significantly in P. corylifolia model group （P＜0.05 or P＜0.01）；while GSH and SOD levels ，mitochondrial membrane potential were decreased significantly （P＜0.05 or P＜0.01）. Compared with P. corylifolia model group ，above indexes of P. corylifolia -S. chinensis low-dose， medium-dose and high-dose groups were all improved significantly （P＜0.05 or P＜0.01）. CONCLUSIONS The compatibility of P. corylifolia -S. chinensis can alleviate P. corylifolia -induced oxidative damage and endoplasmic reticulum stress of L 02 cells.

Diagnostic value of Caprini score for acute pulmonary embolism / 中国基层医药

Objective:To explore the diagnostic value of Caprini score for acute pulmonary embolism(APE).Methods:Totally 2 764 patients with suspected APE admitted to Yuncheng Central Hospital were enrolled from January 2012 to January 2019, and 312 patients were diagnosed APE and assigned to APE group finally.Among the patients without APE, 312 patients(control group) were matched with the patients in APE group according to age, gender, weight, blood pressure, surgical history, etc.The general clinical data of the two groups were collected, and the Caprini score of each patient was recorded.The differences between the two groups in clinical data and Caprini score were compared.The area under curves(AUC) of receiver operating characteristic(ROC) was calculated to predict the diagnostic efficacy of Caprini scale for patients with APE.Results:The Caprini score of the APE group was significantly higher than that of the control group[(5.41±2.47)points vs.(2.16±1.28)points, t=1.180, P=0.004]. The Caprini score had a favorable diagnostic efficacy for patients with suspected APE(AUC=0.915, 95% CI: 0.878-0.995, P<0.001), and when the 3.5 cutoff value of Caprini score was determined, the specificity and sensitivity were 87.76% and 95.24%, respectively, with 7.778 of positive likelihood ratio, 0.054 of negative likelihood ratio, and 0.83 of Youden index. Conclusion:Caprini score has strong diagnostic efficacy in patients with APE.

Research progress in non-invasive brain stimulation technique for rehabilitation of traumatic brain injury / 中华创伤杂志

Traumatic brain injury (TBI) is a leading cause of death and disability in young adults,leaving patients with multiple sequelae and dysfunction,including cognition,sensation,motor dysfunction and chronic pain.Rehabilitative treatment of functional disorders can help improve the quality of life for TBI patients and help them return to work.Currently,medication and exercise rehabilitation are often adopted,yet with certain limitations.Non-invasive brain stimulation (NBS) mainly includes transcranial magnetic stimulation,transcranial direct current stimulation,low-energy laser therapy,and transcranial Doppler ultrasound.Currently,many studies have been exploring the application of NBS in TBI treatment.NBS is expected to play an important role in improving cognition,sensation,motor function and alleviating chronic pain,providing a new approach for the rehabilitation of TBI patients.This article reviews the common dysfunction after TBI and NBS application in TBI treatment in order to provide reference for its further application.

Research on integrated information literacy education in medical colleges / 中华医学教育探索杂志

This article outlined the necessity of integrated information literacy education,ex-pounded the connotation of information literacy and integrated education and analyzed the situation of integrated information literacy education in China's medical colleges. In the end,the measures of inte-grated information literacy education were promoted from the following perspectives:improving the level of information literacy of professional teachers,designing the curriculum system of information literacy,integrating with medical professional courses,and establishing a network learning platform with professional education and information literacy education.