Advances in analytical techniques for the determination of genotoxic impurities in pharmaceuticals / 中国药科大学学报

@#Genotoxic or potentially genotoxic impurities seriously threaten people′s health, therefore, it is necessary to identify and quantify these impurities in pharmaceutical materials even at trace levels. Due to the special requirements on the sensitivity, selectivity, analyte stability and matrix effect, development of analytical methods is a challenge for the determination of genotoxic impurities. This paper reviews the recent advances in analytical methods for trace levels of commonly encountered genotoxic or potentially genotoxic impurities, including alkyl halides, alkyl sulfonates, hydrazines, epoxides and acyl halides, which would be helpful to control these impurities.

A survey on the knowledge and behavior in asthmatic children's parents in Tianjin / 中国综合临床

Objective To investigate the understanding level of asthma related knowledge and the treatment compliance in parents of children with asthma in Tianjin. Methods Questionnaire survey was given to 93 randomly selected parents of children with asthma at our asthmatic clinic ,whose children began to receive regularly asthmatic administration for at least 6 months from June to July in 2009. Results 72.04% of the parents included into the survey knew that asthma was a chronic airway inflammatory disease; 100% of them adhered to use prescription inhaled corticosteroid (55.91%) or inhaled corticosteroid combined with an inhaled long-acting β2-agonist (44. 09% ) ;74. 68% of them believed that if the child is in a well control state, he/she could participate in exercise as healthy children. There were 93.55% and 97.85% children patients aged ＞ 5 had never used PEF meter or CACT respectively to monitor the ill conditions. 25.81% of the parents chose rapid-acting β2-agonist to deal with asthma at acute attack stage, while 19.35% chose to add antibiotics and 11.83% were unable to do anything. 43.01% of the parents worried that the long-term use of inhaled corticosteroid would have side effects on the growth and development of their children, although they chose to obey to the doctor's prescription. Conclusions The general understanding of asthma is good in the parents, whose children had received asthmatic administration regularly in Tianjin area,but there are still some weak links exist. The related education may help asthmatic children's parents to master the knowledge of asthma, give them correct recognition of the treatment and prevention of asthma,increase the treatment compliance. This work should be insisted continuously.