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Objective To explore the correlation between the levels of estradiol E2 and testosterone T in serum and expressed prostatic secretion(EPS) with the erectile function in the patients with type Ⅲ prostatitis(CP/CPPS) .Methods The E2 and T lev‐els in serum and EPS from 64 cases of CP/CPPS ,including 35 cases of type Ⅲ A and 29 cases of Ⅲ B ,and 20 individuals of physical examination were detected by using the radioimmunoassay .All cases were evaluated by the scores of NIH‐CPSI and the Internation‐al Index of Erectile Function 5(IIEF‐5) .64 patients were grouped according to the IIEF‐5 scores ,the erectile dysfunction(ED) group(32 cases) and the non‐ED group(32 cases) .Results The mean E2/T levels in serum and EPS of the Ⅲ A group and the Ⅲ B group were higher than those in the control group ,the difference had statistical significance(P0 .05 .There was a positive correlation between the IIEF‐5 score and the T level in serum and EPS in the CP/CPPS group(r=0 .218 ,r=0 .231 ,P0 .05) .The serum T level in the ED group was (6 .32 ± 1 .86)ng/mL ,which was lower than(7 .89 ± 2 .92)ng/mL in the non‐ED group and (8 .41 ± 2 .02)ng/mL in the control group ;the .E2/T level in EPS in the ED group was (55 .02 ± 29 .26) ,which was higher than (14 .06 ± 9 .36) in the non‐ED group and (16 .45 ± 13 .76) in the control group ,the differences among them were statistically significant (P<0 .05) .Con‐clusion The imbalance degree of hormone estradiol and testosterone in serum and EPS is related with erectile function in the pa‐tients with CP/CPPS .
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Objective To investigate the level and clinical significance of nerve growth factor ( NGF) , transforming growth factor ( TGF )-β1 , estradiol ( E2 ) and testosterone ( T ) in serum and ex-pressed prostatic secretion (EPS) of patients with category Ⅲprostatitis. Methods From August 2011 to January 2012, 64 patients with (chronic prostatitis/chronic pelvic pain syndrome , CP/CPPS) and 20 health people were enrolled in this study.In CP/CPPS group, the age of patients ranged from 18 to 56 years, mean (36.6±9.3) years.The history of CP/CPPS ranged from 3 months to 6 years, mean 2 years.All patients were asked to complete NIH-CPSI questionnaires with CP/CPPS, including group ⅢA 35 cases and groupⅢB 29 cases.The age of healthy controls ranged from 25 to 41 years.The average healthy control age was (33.1±3.9) years.EPS and serum samples from CP/CPPS and control group were collected and frozen . NGF, TGF-β1 , E2 and T level in EPS and serum were measured by ELISA and radioimmunoassay and com -pared in each group. Results The mean E2, E2/T, TGF-β1 level in serum of patients with CP/CPPS were (175.7±82.4) pmol/L, (7.9±6.7), (2 216.2±581.6) ng/L, which were higher than that in healthy controls, (131.7±49.4) pmol/L, (4.6±2.4), (1 599.8±469.5) ng/L.The mean T level in CP/CPPS pa-tients′serum was (24.7±8.9) nmol/L, which was lower than that in controls (29.2±7.0) nmol/L.The E2/T (34.5±29.8), TGF-β1(6 859.3±5 229.4 ng/L), NGF (467.0±164.3 ng/L) levels in EPS of CP/CPPS patients were higher than that in controls (16.5±13.8), (1 774.1±1 304.3) ng/L, (310.8±106.6) ng/L. The TGF-β1 level in EPS of CP/CPPS patients showed the positive correlation ship with urination symptom score (6.1±2.4) (r=0.641, P<0.05).The NGF level in EPS of CP/CPPS patients also showed the positive correlation ship with pain score (7.6±2.6) (r=0.497, P<0.05).E2/T,TGF-β1 levels in serum and E2/T, TGF-β1,NGF levels in EPS of group ⅢA were (7.1±4.6), (2131.5±412.0)ng/L and (31.5±22.3), (7 667.1±5 652.4)ng/L, (440.6±134.3)ng/L, which were significantly higher than those in healthy con-trol (P<0.05).E2/T, TGF-β1 levels in serum and E2/T, TGF-β1, NGF levels in EPS of group ⅢB were (8.9±8.5), (2 340.5±728.2) ng/L and (38.2±37.1), (5 884.4±4 574.3) ng/L, (498.9±192.1) ng/L, which were also higher than those in healthy control ( P<0.05) . Conclusions Hormonal imbalance in es-tradiol and testosterone with TGF-β1 , NGF higher levels in EPS is closely related with pathogenesis and clin-ical symptom of category III chronic nonbacterial prostatitis .
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Objective To determine the relationship between blood biochemical metabolites and benign prostatic hyperplasia (BPH).Methods From Jan.2008 to Oct.2010,the medical records of 73 BPH patients diagnosed by postoperative histopathology were retrospectively studied.The age of patients ranged from 55 to 86 years.The average patient age was 70 years.Of the 73 cases,65 cases were not taking medications which could have an impact on metabolic levels of serum glucose and lipoprotein.Three months prior to operation,the patients were placed in a group to analyze the correlation between the total volume of the prostate (TP),prostate average annual growth rate and biochemical metabolites including serum glucose,high-density lipoprotein cholesterol (HDL-c) and prostate specific antigen (PSA).To compare the changes of prostate volume,prostate annual growth rate and PSA,the 73 cases were divided into two groups; patients with metabolic syndrome (MS) and those without MS.Results Of the 65 BPH patients,the mean of TP and prostate annual growth rate were (58.76 ± 25.96) ml and (1.32 ± 0.89) ml,serum glucose was (4.99 ± 0.73) mmol/L,HDL-c was (1.36 ± 0.39) mmol/L,and PSA was (5.99 ±8.30) μg/L.Stratified with prostate volume,patient's serum glucose,prostate annual growth rate and PSA levels increased with the increased TP (F =4.63,P =0.0060; F =62.98,P =0.0001 ; F =4.83,P =0.0044).On the other hand.HDL-c decreased with the increased TP (F =5.32,P =0.0025).There was a positive relationship between TP and serum glucose (r =0.48,P =0.0005).There was a negative correlation between TP and HDL-c (r =-0.26,P =0.0353).Of the 73 patients,20 cases had MS.The MS group had PSA levels (6.52 ± 5.28) μg/L,TP (79.41 ± 38.24) ml and prostate annual growth rate (1.86 ± 1.14) ml.These levels were higher than the 53 cases without MS.The group without MS had PSA levels (3.95 ± 3.77) μg/L,TP (54.98 ± 20.94) ml and prostate annual growth rate (1.23 ± 0.80) ml (t=2.29,P=0.0253; t=2.65,P=0.0147; t=2.22,P=0.0360).Conclusions PSAlevels,TP and prostate annual growth rate in BPH patients are related with blood biochemical metabolites.Both serum glucose and HDL-c affect prostate volume.BPH patients with MS have a remarkable clinical progression.