The impact of long- and short-time blood pressure variability on glomerular filtration rate in elderly population / 中华心血管病杂志

<p><b>OBJECTIVE</b>To investigate the impact of long-time and short-time blood pressure variability (BPV) on glomerular filtration rate (eGFR) in elderly population.</p><p><b>METHODS</b>A total of 2 464 participants aged of ≥60 years old without history of stroke and coronary heart disease were selected with random sampling method from the individuals underwent health check up in Tangshan Kailuan Hospital, Kailuan Linxi Hospital, Kailuan Zhaogezhuang Hospital between 2006 and 2013. The study participants were asked to join a face-to-face interview every two years. Long-time BPV was defined as the standard deviation of all SBP values at the baseline visit and following visits, short-time BPV was defined as the standard deviation of day time blood pressure and night time blood pressure which was derived from 24 hours ambulatory blood pressure monitoring. Multivariate linear regression models were used to test the impact of long- and short-time BPV on eGFR.</p><p><b>RESULTS</b>The study included 3 participants groups including the long-time SBPV group (2 279 participants), the short-time SBPV group (1 636 participants) and the long- plus short-time SBPV group (1 632 participants). Participants were further sub grouped by median value (NO.1<meadian and NO.2>median value). eGFR in the long-time SBPV NO.1 and NO.2 group was 83.19 and 81.49 ml·min(-1)·1.73 m(-2) respectively, in the short time SBPV NO.1 and NO.2 group was 83.53 and 80.81ml·min(-1)·1.73 m(-2) of the day time, and was 83.20 and 81.14 ml·min(-1)·1.73 m(-2) of the night time, respectively. eGFR in the long- plus short-time SBPV NO.1 and NO.2 group was 83.21 and 81.08 ml·min(-1)·1.73 m(-2) of the long-time SBPV, and was 83.53 and 80.75 ml·min(-1)·1.73 m(-2) of the day time, and was 83.18 and 81.11 ml·min(-1)·1.73 m(-2) of the night time. Significant linear relationship was found between higher day time SBPV and lower eGFR (P<0.05). After adjusting for confounding parameters including age, sex, body mass index, 1 mmHg(1 mmHg=0.133 kPa) of day time SBPV increase was related 0.21 ml·min(-1)·1.73 m(-2) eGFR decrease (P<0.05).</p><p><b>CONCLUSION</b>The higher day time SBPV is associated with reduced eGFR in the elderly population.Clinical Trail Registry Chinese Clinical Trial Registry, ChiCTR-TNC-11001489.</p>

Correlation between long time systolic blood pressure variability and short time systolic blood pressure in aged population / 中华心血管病杂志

<p><b>OBJECTIVE</b>To investigate the correlation between long time systolic blood pressure variability(SBPV)and short time SBPV in aged population.</p><p><b>METHODS</b>A total of 752 subjects aged ≥60 years of Kailuan Group who took part in 2006-2007, 2008-2009, 2010-2011 and 2012-2013 health examination were included by cluster sampling method.Long time SBPV was calculated by standard deviation of mean systolic blood pressure measured in 2006-2007, 2008-2009, 2010-2011 and 2012-2013, standard deviation represents short time systolic blood pressure which is derived from 24 hour ambulatory blood pressure monitoring. The observation population was divided into three groups according to the third tertiles of the time systolic blood pressure variability: the first point(<9.09 mmHg (1 mmHg=0.133 kPa)), second point (≥9.09 mmHg, and <14.29 mmHg), and third point (≥14.29 mmHg). Multivariate logistic regression analysis was used to analyze the correlation between long time systolic blood pressure variability and short time systolic blood pressure.</p><p><b>RESULTS</b>(1) The participants' age were (67.0±5.7) years old (284 women). (2) The 24 hours and daytime SSD were (14.7±4.0) mmHg, (14.7±3.5) mmHg, (15.7±4.4) mmHg (P=0.010) and (14.1±4.4) mmHg, (14.2±3.5) mmHg and (15.4±4.6) mmHg (P<0.001) according to the tertiles of long time systolic blood pressure variability, respectively, nighttime SSD were (12.0±4.4) mmHg, (11.8±4.8) mmHg and (11.9±4.9) mmHg (P=0.900). (3) Multiple logistic regression analysis showed that the tertiles of long time SSD was the risk factor for increasing daytime SSD>14.00 mmHg (OR=1.51, 95%CI: 1.03-2.23, P=0.037), but not a risk factor for increasing 24 hours SSD>14.41 mmHg (OR=1.10, 95%CI: 0.75-1.61, P=0.639) and nighttime SSD>11.11 mmHg (OR=0.98, 95%CI: 0.67-1.42, P=0.899).</p><p><b>CONCLUSION</b>Increased long time SBPV is a risk factor for increasing daytime SBPV.</p>

Impact of resting heart rate on the progression to hypertension in prehypertension patients / 中华心血管病杂志

<p><b>OBJECTIVE</b>To observe the effect of resting heart rate (RHR) on the progression to hypertension in patients with prehypertension.</p><p><b>METHODS</b>People who participated the physical examination between 2006 and 2007 at Kailuan medical group and diagnosed as prehypentension were selected as the observation cohort. The second and the third physical examination were conducted between 2008 and 2009 and between 2010 and 2011. The observation population was divided into five groups according to the different levels of RHR at baseline: the first group ( ≤69 beats/min), the second group (70-74 beats/min), the third group (75-79 beats/min), the fourth group (80-84 beats/min) and the fifth group ( ≥85 beats/min). The rate of the progression to hypertension was compared among five groups, and the relationship between RHR and the progression to hypertension was estimated using Cox proportional hazard analysis.</p><p><b>RESULTS</b>A total of 34 512 patients with prehypentension were recruited and 25 392 patients were involved in the final statistics after excluding patients who died or were lost to follow-up. A total of 13 228 (52.1%) patients with prehypentension developed hypertension during follow-up. The rate of the progression to hypertension increased with the RHR (first group: 51.2%, second group: 50.1%, third group: 52.9%, fourth group: 53.5%, fifth group: 57.5%). Multiple Cox regression models showed that the risk of the progression to hypertension increased with the RHR levels. Patients in the fifth group carried 1.25 times higher risk for developing hypertension than patients in the second group after adjustment for age, gender, systolic blood pressure, diastolic blood pressure, waist circumference, body mass index, triglyceride, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, fasting blood glucose, serum uric acid, C-reactive protein, smoking, drinking, physical exercise and family history of hypertension at baseline.</p><p><b>CONCLUSION</b>Elevated RHR is an independent risk factor for the progression to hypertension in patients with prehypertension.</p>

The relationship between angiotensin Ⅱ type 1 receptor gene A1166C polymorphism and chronic heart failure / 中国综合临床

Objective To investigate the relationship of angiotensin Ⅱ typel receptor gene A1166C polymorphism and chronic heart failure.Method Polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP)was used to detect the A1166C polymorphism of AT1R gene of 135 chronic heart failure patients and 121 controls.Results The genotype frequency of the patients and controls of AA,AC,CC were 87.6%.12.4%,0%and 87.6%,11.6%,0.8%respectively.Allele frequency of the patients and controls were 93.8%,6.2%and 93.6%,6.4%respectively.There was no significant difference of the frequency of AT1R genotype and allele between CHF and controls(P＞0.05).Conclusion Angiotensin Ⅱ type 1 receptor gene A1166C polymorphism is not associated with CHF.

A case-control study on risk factors of stroke in elderly male / 中国实用内科杂志

Objective To evaluate odds ratio(OR)of common risk factors and independent risk factors of stroke in elderly male.MethodsOutpatients and inpatients from hospital who aged≥65 year and male were enlisted in the study.Patients diagnosed as stroke were defined as case group and without history of stroke were defined as control group.A uniform questionnaire was designed for investigate general information and common risk factors of stroke.Odds ratio of risk factors were estimated by a case-control design and Multiple Logistic regression was applied to define independent risk factor.ResultsUnivariate analysis indicated that systolic,diastolic,mean blood pressure,weight,body mass index(BMI)in case group were significantly higher than that in control group.Hypertension,heart disease,diabetes,obesity,cigarette smoking and alcohol drink were the statistically significant risk factors of stroke.Ors of these risk factors were 2.26,1.57,2.57,1.96,1.49 and 1.54,respectively.Multiple Lgistic regression analysis showed that cigarette smoking,diabetes,obesity and hypertension were the factors being selected into equation.ConclusionCigarette smoking,diabetes,obesity and hypertension were the independent risk factors of stroke in elderly male.

A comparison between external fixation with external fixation apparatus in entire period with external fixation apparatus and plaster in different period for treatment of open fractures of tibia and fibula / 临床外科杂志

Objective To study the results of treatment of open fracture of tibia and fibula by external fixation with unilateral multifunction external fixation apparatus(UMEFA) and plaster in different period. Methods 89 cases with open fracture of tibia and fibula had got reduction and external fixation with UMEFA and then divided into two groups, group A of 53 cases followed by external fixation with UMEFA, 8 cases of them were forced to remove UMEFA because of complications, the other 45 cases followed by external fixation with UMEFA till bone union, group B of 36 cases were removed UMEFA and changed with plaster when the skin was healed, the sweal was eliminated and the bone was steady. Compared and analyzed the results by complication, healing time and quality.Results In group B, there was less complications(P