Social Ethical Reflection on COVID-19 Epidemic from the Perspective of Caring Ethics / 中国医学伦理学

COVID-19 has caused global concern and called for emergency response measures. In this continuous epidemic crisis, ethics has suffered unprecedented huge impact and challenges. It is the responsibility of contemporary ethics to reflect on the moral dilemma existing in itself and in the world. Therefore, ethics must stand the test and provide legitimate reasons for how to give full play to relevance and availability in this global crisis. The theory of rule ethics, which focuses on the realization of moral obligations and rights, is obviously unable to adapt to the response to the demand for ethical responsibility in special periods. The ability to take moral actions against others requires the intervention of "empathy" and "care" factors to realize the possibility of changing from heteronomy to self-discipline. Caring ethics emphasizes that "empathy" and "care" should be wisely regarded as an important value under the COVID-19 epidemic, so as to minimize the possible of the COVID-19 spread and its mutation and escalation in daily interpersonal communication, and create more meaningful ethical relationships with others by being responsible for and caring for others. At the same time, caring ethics further emphasizes that ignoring the cognition may lead to continuous psychological impact, making it difficult to reconstruct a harmonious social psychological situation.

Analysis of etiology and cytokines of benign infantile convulsions with mild gastroenteritis / 中国小儿急救医学

Objective:To investigate the pathogenic distribution of benign infantile convulsions with mild gastroenteritis(BICE)and explore the relevance of serum cytokines and BICE.Methods:Eighty BICE infants admitted in Inner Mongolia Maternal and Child Health Hospital from January 2017 to December 2019 were selected as BICE group, and 80 mild gastroenteritis infants without convulsion attack were selected as control group during the same period.Fluorometric real-time PCR was used to detect the pathogen of enterovirus.Serum cytokines including interleukin(IL)-6, tumor necrosis factor(TNF)-α, IL-8 and soluble interleukin-2 receptor(SIL-2R)were detected by using chemiluminescence method.The relevance of frequency and duration of convulsion in infants with BICE and the indicators above were analyzed.Results:Rotavirus infection was the main cause of BICE during the study period in this region.Among 80 cases in the BICE group, rotavirus positive infants accounted for 38.8%(31/80) and norovirus positive infants accounted for 10.0%(8/80). The levels of IL-6, IL-8 and SIL-2R in the BICE group were prominently higher than those in the control group( P<0.05); the difference of TNF-α level between two groups had no statistical significance( P>0.05). The levels of IL-6, TNF -α, IL-8, SIL-2R in the group with convulsion attack times ≥ 2 and convulsion duration ≥5 min were higher than those in the group with convulsion attack times<2 and convulsion duration<5 min( P<0.05). The frequency and duration of convulsions were positively correlated with the levels of IL-6, TNF -α, IL-8 and SIL-2R( P<0.05). Conclusion:Rotavirus is the main pathogen of BICE in this region.There is immunologic imbalance in children with BICE, especially the changes of IL-6 and SIL-2R levels, which may provide effective cytological and experimental data evidence for judging progression and prognosis of the disease.

Peripheral nerve injury in LAMA2-related congenital muscular dystrophy patients / 中华儿科杂志

Objective@#To explore the injury pattern and features of peripheral nerve in congenital muscular dystrophy patients caused by LAMA2 gene mutation.@*Method@#Seventeen patients genetically or molecular pathologically diagnosed as LAMA2-related congenital muscular dystrophy were recruited in Peking University First Hospital between 2002 and 2015. All the patients received nerve conduction velocity (NCV) and needle electromyography tests. Clinical and laboratory examination data of the patients was retrospectively analyzed. The correlation between the NCV and disease course was determined by Pearson correlation analysis. Additionally, one patient underwent a sural nerve biopsy.@*Result@#Among these 17 identified patients (13 male and 4 female), all of them were diagnosed as congenital muscular dystrophy, and all of them underwent electrophysiological examination at ages between 1 month to 6 years. Electromyogram indicated seventeen patients of myogenic damage, of whom 10 cases were complicated with reduced NCV. Twenty-six of 95 analyzed nerves showed NCV slower than the normal average of contemporary in 17%-47%. Correlation analysis between NCV and the disease course indicated that NCV of median nerves, ulnar nerves, tibial nerves and common peroneal nerves were negatively associated with the disease course (r=-0.737, -0.771, -0.540 and -0.682, respectively; all P<0.05). Sural nerve biopsy revealed peripheral neuropathy changes of myelin.@*Conclusion@#There is peripheral nerve injury in LAMA2-related muscular dystrophy patients. It mainly manifests as demyelinating lesions. Moreover, the NCV of peripheral nerve will decrease with the increase of the course of the disease.

Large diameter esophagogastric internal fistula combined with fundoplication for treatment of achalasia / 局解手术学杂志

Objective To explore the clinical the efficacy of large diameter esophagogastric internal fistula combined with fundoplication and modified Heller surgery for treatment of achalasia.Methods From June 2008 to March 2014,18 patients diagnosed as achalasia were se-lected into this suty,and they were divided into the observation group (8 cases)and the control group (10 cases).Patients of the observation group were received large diameter esophagogastric internal fistula combined with fundoplication while patients of the control group received modified Heller surgery.Compared the surgical curative effect and complications between the two groups.Results All the 18 patients suc-cessfully completed the arranged surgical treatment.The imaging examination 3 months after the operation showed that the contrast agent suc-cessfully passed through the esophagus,cardia and the anastomosis,and then went into the gastric lumen.The total effective rate was 100% in the observation group 12 months after operation,while it was 60% in the control group,and the difference between the two groups was statisti-cally significant (P =0.014).The incidence of complications in the observation group was lower than that of the control group,the difference was statistically significant (P =0.026).Conclusion Large diameter esophagogastric internal fistula combined with fundoplication for treat-ment of achalasia is safer,and there is a possibiltiy to cure the achalasia.

Relationships between posttraumatic growth and psychological distress among patients with prostate cancer / 现代临床护理

Objective To investigate the level and relationships of posttraumatic growth (PTG) and psychological distress among patients with prostate cancer. Method Totally 116 patients with prostate cancer involved in the investigation by a self-designed demographic questionnaire, posttraumatic growth inventory (PTGI) and distress thermometer (DT). Results The total score of PTGI was (53.12 ± 13.51), at a low level, and the score of DT was (4.32 ± 2.59), at a medium level. The score of DT was negatively correlated to the scores of PTG and its dimensions (all P<0.05). Conclusions Patients with prostate cancer show a low level of PTG and a medium level of psychological distress and they are negatively related . Therefore , nurses should take measures to reduce the patients psychological distress and then improve their PTG level.

Analysis of the status and influencing factors of quality of life in patients with chronic obstructive pulmonary disease / 重庆医学

Objective To understand the quality of life in patients with chronic obstructive pulmonary disease (COPD) ,and to analyze the influencing factors for their quality of life .Methods A total of 250 patients with COPD from 3 hospitals in Zhanjiang City were investigated by using the Chinese Scale Of World Health Organization (WHOQOL‐BREF) ,and the influencing factors for quality of their life were analysed ,as well .Results A total of 237 qualified questionnaires were reclaimed out of 250 questionnaires , and the response rate was 94 .80% .Scores of physiological aspect ,psychological aspect ,social relation ,environmental condition and comprehensive health self evaluation were (59 .57 ± 15 .73) ,(56 .99 ± 13 .01) ,(64 .28 ± 14 .82) ,(58 .70 ± 11 .53)and (74 .97 ± 12 .61) ,respectively .The scores of quality of life in the physiological aspect ,psychological aspect ,social relation and environmental condition of male patients with COPD were higher than those of the female ;the scores of quality of life in the social relation in pa‐tients with higher education level were higher than that in patients with lower education level ,the scores of quality of life in the physiological aspect ,psychological aspect ,social relation and environmental condition in patients with higher income level were high‐er than those in patients with lower income level ;the disease severity was higher ,the scores of quality of life in the physiological as‐pect ,psychological aspect ,social relation and environmental condition were lower ,all had statistically significant differences (P<0 .05) .Logistic regression analysis showed that sex ,monthly income level and disease severity were the influence factors of quality of life self evaluation in COPD patients .Conclusion The quality of life in patients with COPD might be influenced by sex ,income level ,level of education and disease severity .It is necessary to strengthen the health education ,pay attention to personalized care and improve the quality of life of patients with COPD .

Effect of compatibilities and proportions of shuanglong formula on acute myocardial infarction in rats / 中国中药杂志

<p><b>OBJECTIVE</b>To verify the rational of Chinese medicine Shuanglong formula.</p><p><b>METHOD</b>Rat models of acute myocardial ischemia were induced by hydrochloride isoproterenol. ECG J point change, myocardial infarction area and cellular enzyme (CK, LDH, SOD and MDA) levels were observed and detected to show protective effect of treatment groups.</p><p><b>RESULT</b>The single drug prescriptions and compatibilities both could improve ECG performance, decrease levels of CK, LDH, SOD and MDA in serum, and reduce a certain myocardial infarct size.</p><p><b>CONCLUSION</b>The Shuanglong formula at the high dose of 3:7 was proved to be more effective on myocardial ischemia.</p>

Nursing of patients with early severe acute pancreatitis undergoing laparoscopic treatment / 中国实用护理杂志

Objective To discuss nursing of patients with early severe acute pancreatitis undergoing laparoscopic treatment and in comparison with open surgery. Methods Totally 56 patients with early se-vere acute pancreatitis were admitted from October 2002 to October 2007,among which 30 cases (group A) received laparoscopic.treatment and the other 26 cases (group B) was given open surgery.The average time of hospital stay,incidence of complication and re-operation were compared between the two groups. Re-sults The average time of hospital stay,incidence of complication and re-operation of group A were lower than those of group B (P<0.05). Conclusions Treatment of severe acute pancreatitis with laparoscopy proved to be a desirable method in that it performs good effect with little trauma and low fatality.Other basic treatment,regulation of water and electrolyte balance and acid-base balance,enforcement of nutritional sup-port,fasting and gastrointestinal decompression should not be ignored.

Relationships between serum levels of adiponectin and essential hypertension in the people with overweight and obesity / 中国医师杂志

Objective To explore the relationships between serum levels of adiponectin and essential hypertension in the people with overweight and obesity.Methods The body mass index(BMI),waist circumference(WC),waist-hip ratio(WHR) and blood pressure(BP) were measured among 21578 people from 21 to 60 years old in Shenzhen.According to BMI,the people were divided into the normal-weight group(BMI≤24kg/m~2)(n=14817),the overweight group(2495 cm,respectively(all P0.05).The serum levels of adiponectin were negatively correlated with BMI,WC,WHR and systolic blood pressure in the hypertension obesity cases.Conclusion Adiponectin may be intimately related to obesity and essential hypertension.Keeping the BMI and WC at normal range is one of the effective ways to prevent the risk of essential hypertension.

Changes of bone mineral density, bone metabolism indices and Vitamin D receptor content in patients with hyperthyroidism / 中华内分泌代谢杂志

Bone mineral density (BMD) of lumbar spines, femoral neck, Ward′s triangle and greater trochanter was lowered, serum calcium, phosphate, alkaline phosphatase and bone Gla-protein levels were raised, and vitamin D receptor (VDR) contents in lymphocyte was lowered in hyperthyroid patients. Both FT 3 and FT 4 were negatively correlated with BMD, suggesting that hyperthyroidism results in high-turnover type of bone loss which causes the abnormalities of bone metabolic indices and VDR content.