RESUMO
The pathogenesis of diabetic retinopathy (DR) is complex.Antisense non-coding RNA (ANRIL) in the INK4 locus in long-chain non-coding RNA (lncRNA) is closely related to cell proliferation,differentiation,and individual development.It plays an important role in the dysplasia of retinal vascular endothelial cells and is a new field in the study of the pathogenesis of DR.According to the researches at present,ANRIL may plays its role in the occurrence and development of DR through the signal pathway of nuclear factor-κB and ROS/polyadenylation diphosphate ribose polymerase,and interact with p300,miR-200b,and EZH2 to regulating the expression and function of VEGF.Specific blocking ANRIL and its related pathwaysmay become a new target in the treatment of DR.
RESUMO
Objective To explore the clinical features and radiological findings of patients with Sturge-Weber syndrome (SWS).Methods A retrospective study was performed on the course of illness,clinical data and neuroimages of 8 patients with SWS,admitted to our hospital from June 2012 to November 2015.Results The main symptoms included facial hemangioma in 7 patients,epilepsy in 5 patients,headache in 4 patients,limb hemiplegia in 3 patients,glaucoma in 3 patients,and thyroid dysfunction in one patient.Neurological imaging showed subcortical calcification,brain atrophy,gyriform enhancement and increased pial vascular tortuosity.Fundus examination revealed optic atrophy and vascular malformations of choroid.All symptoms in the patients were alleviated after treatment.Conclusions SWS should be highly suspected in young patients who present with typical glaucoma,epilepsy or hemiplegia with/without facial hemangioma.CT angiography or MR imaging (especially susceptibility-weighted imaging) is required to confirm the diagnosis.If medications fail to control seizures,surgery could be considered in some patients.