Research progress in application of different types of hemostatic materials in trauma first aid / 中华创伤杂志

Hemostatic materials are essential for the treatment of trauma patients with massive blood loss in battlefields and disaster environments. According to the site and severity of trauma, different types of hemostatic materials need to be used to stop bleeding urgently. At present, first-aid hemostatic materials for bleeding on body surface wounds, extremities and junctions have been well applied. However, in the case of deep bleeding wounds in the thoracic and abdominal cavity and internal organs and even non-compressible hemostasis, there are still no ideal hemostatic materials in early emergency treatment. In this review, the authors elaborate the classification and mechanism of hemostatic materials and their application in trauma first aid, so as to provide references for the use of hemostatic materials in first aid.

Spatial and temporal distribution of Aedes albopictus monitored by mosq-ovitrap in Songjiang District of Shanghai in 2018—2020 / 上海预防医学

Objective Based on mosq-ovitrap monitoring method of Aedes albopictus， to determine the spatial and temporal distribution of Aedes albopictus in Songjiang District and provide scientific evidence for prevention and control of mosquito-borne diseases. Methods From May to October， 2018‒2020， density of Aedes albopictus was monitored by using the mosq-ovitrap method. Sub-districts and towns were used as the monitoring units and the difference in mosquito ovitrap index （MOI） was compared by seasons， years and habitats. Results The total number of positive mosquito ovitraps was 1049 in 2018‒2020， and the average MOI was 8.10. Four sub-districts/towns in the urban area and the northern area had the relatively high MOIs. Moreover， MOIs in residential and external environments were higher than other habitats. In addition， MOI of Aedes albopictus decreased over years from 2018 to 2020. Conclusion Aedes albopictus is widely distributed in Songjiang District. Although the number of mosquito decreased over years after the implementation of mosquito control measures， reproduction of mosquito remains excessive in some areas and seasons. It is necessary to perform targeted control measures based on comprehensive monitoring methods.

Study on the correlation of waist-to-height ratio and triglyceride with cerebrovascular hemodynamics and stroke / 公共卫生与预防医学

Objective To explore the correlation of waist-to-height ratio (WHtR) and triglycerides (TG) with changes in cerebral hemodynamic index (CVHI) and the risk of stroke. Methods From March 2018 to March 2019, a total of 500 medical examinees were selected from the civil servants who underwent a physical examination in the physical examination department of our hospital. According to the TG level, the subjects were divided into two groups: HTG group (208 cases) and normal group (292 cases). According to WHtR value, the subjects were divided into an abnormal group (216 cases) and a normal group (284 cases). According to the test results, CVHI and other information the stroke risk was analyzed among the 4 groups. Results The right Vmax and bilateral Qmean, Vmean, Vmin, and Dp in the HTG group were significantly lower than those in the normal group (P<0.05), while the bilateral Wv, Zcv, Rv, DR, and Cp were higher than those in the normal group (P<0.05). The parameters of bilateral Vmax, Qmean, Vmean, Vmin, and Dp in the abnormal group were significantly lower than those in the normal group (P<0.05), while the bilateral Wv, Zcv, Rv, DR, and Cp were higher than those in the normal group (P<0.05). The CVHI scores of the HTG group and the abnormal group were lower than those of the normal group (P<0.05), and the FSP scores were higher than those of the normal group (P<0.05). The proportion of high-risk strokes with CVHI<75 and FSP score ≥10 in the HTG group were both higher than that in the normal group (P<0.05). There were 4 predictors including HTG, WHtR, CVHI score, and FSP score. There was a statistically significant difference in the etiology of stroke between CVHI and FSP (P<0.05). The risk of stroke in patients with abnormal WHtR increased by 2.746 times, and the relative risk of stroke in patients with CVHI<75 increased by 3.298 times. Conclusion WHtR abnormality and CVHI<75 were two independent predictors of stroke risk. HTG may increase the risk of stroke by affecting cerebral hemodynamic indicators.

Effect of interleukin6 on the malignant progression of ovarian cancer / 中国综合临床

Modern oncology believes that tumor-associated inflammation is one of the prominent features of tumor microenvironment.The occurrence and development of ovarian cancer is inseparable from the influence of inflammatory factors in the microenvironment.Interleukin-6 (IL-6) is an important pro-inflammatory factor that regulates tumor cell growth.Current studies found that the expression of IL-6 and IL-6 receptor both increase in patients with ovarian cancer, which are closely related to poor clinical prognosis.The mechanism of effect of IL-6 on the malignant progression of ovarian cancer has been a research hotspots in the field of tumor microenvironment.In combination of the research results of this group in recent years, we mainly review the role of IL-6 in ovarian cancer including proliferation, invasion and metastasis, blood system disorders and drug resistance.Then, we introduce the research frontiers and application prospects of IL-6 targeted therapy for ovary cancer.

Effect of transcranial clipping in the treatment of intracranial aneurysms and its influence on hemodynamics, NSE and S100B expression / 中国基层医药

Objective:To investigate the effect of transcranial clipping in the treatment of intracranial aneurysms and its influence on hemodynamics, neuron specific enolase(NSE) and S100B expression.Methods:A retrospective analysis was made in 47 patients with intracranial aneurysms who admitted to Taizhou Hospital of Zhejiang Province from January 2017 to June 2019, all patients were treated by transcranial clipping.The hemodynamics, NSE and S100B levels were compared before operation and 1 week after operation.All patients were followed up for 6 months to evaluate the prognosis.Results:All patients completed the operation, the operation time was (2.79±0.43)h, the intraoperative bleeding volume was (243.51±28.73)mL, the incidence of postoperative complications was 6.38%(3/47), and the average hospitalization time was (16.74±1.86)d.One week after operation, the cerebral blood volume [(27.98±3.24)mL/100g] and cerebral blood flow [(2.08±0.34)mL·100g -1·min -1] were higher than those before operation [(23.41±2.36)mL/100g and (1.56±0.27)mL·100g -1·min -1] ( t=7.816, 8.211, all P<0.05). The serum NSE[(15.28±2.18)μg/L] and S100B[(0.83±0.16)μg/L] were lower than those before operation [(26.39±4.25)μg/L and (1.59±0.27)μg/L]( t=15.946, 16.601, all P<0.05). After follow-up for 6 months, 38 cases(80.85%) had a good prognosis. Conclusion:Transcranial clipping is effective in the treatment of intracranial aneurysms, and can improve hemodynamics, reduce the expression of NSE and S100B in serum, and reduce complications.

The efficacy of microsurgical clipping treatment for intracranial aneurysm rupture and optimal timing research / 中国基层医药

Objective@#To study the clinical efficacy of microsurgical clipping treatment for intracranial aneurysm rupture and optimal timing.@*Methods@#From January 2016 to December 2017, 80 patients with intracranial aneurysm rupture in Taizhou Enze Medical Center(Group) Hospital were randomly divided into the control group (24-72h after rupture) and the observation group (within 24h after rupture) according to the digital table, with 40 patients in each group.The pre- and intra-surgical re-rupture and surgical clipping, post-surgical complications, and clinical efficacy of 6-month follow-up in the two groups were observed and compared.@*Results@#Compared with the control group, the incidence rate of pre-surgical re-rupture was significantly reduced in the observation group (0.0% vs.10.0%, χ2=4.21, P<0.05). Compared with the control group, the incidence rate of post-surgical complications was obviously reduced in the observation group (20.0% vs.42.5%, χ2=4.71, P<0.05). Compared with the control group, the excellent rate of treatment was significantly improved in the observation group (87.5% vs.65.0%, χ2=5.59, P<0.05).@*Conclusion@#The microsurgical clipping treatment can improve the clinical efficacy of intracranial aneurysm rupture and sooner surgery with better prognosis.

The efficacy of microsurgical clipping treatment for intracranial aneurysm rupture and optimal timing research / 中国基层医药

To study the clinical efficacy of microsurgical clipping treatment for intracranial aneurysm rupture and optimal timing.Methods From January 2016 to December 2017,80 patients with intracranial aneurysm rupture in Taizhou Enze Medical Center ( Group) Hospital were randomly divided into the control group (24-72h after rupture) and the observation group (within 24h after rupture) according to the digital table,with 40 patients in each group.The pre-and intra-surgical re-rupture and surgical clipping ,post-surgical complications, and clinical efficacy of 6-month follow-up in the two groups were observed and compared.Results Compared with the control group,the incidence rate of pre -surgical re-rupture was significantly reduced in the observation group (0.0%vs.10.0%,χ2 ＝4.21,P＜0.05).Compared with the control group ,the incidence rate of post -surgical complications was obviously reduced in the observation group (20.0%vs.42.5%,χ2 ＝4.71,P＜0.05).Compared with the control group ,the excellent rate of treatment was significantly improved in the observation group (87.5%vs. 65.0%,χ2 ＝5.59,P＜0.05).Conclusion The microsurgical clipping treatment can improve the clinical efficacy of intracranial aneurysm rupture and sooner surgery with better prognosis.

Self Rating Scale for Self Care Ability of puerperal women using Delphi method / 中国实用护理杂志

Objective To construct a Self Rating Scale for Self Care Ability of puerperal women, and to provide pertinent assessment tools for family, community and hospital to evaluate the self-care ability of puerperium women. Methods Guided by the theory of Orem self-care, the initial scale of Self Rating Scale for Self Care Ability of puerperal women was preliminarily constructed through literature review, qualitative interview, group discussion and Delphi (Delphy expert consultation). Delphi method was used to conduct 3 rounds of questionnaire consultation among 18 experts, and the reliability of the method was tested by expert's positive coefficient, authority coefficient and coordination coefficient. Results The questionnaire recovery rates of 3 rounds of consultation experts were 20/21, 18/20 and 18/18, respectively, coordination coefficient was 0.322, 0.347, 0.502, respectively, and the expert authority coefficient was 0.88. Based on the comprehensive analysis of the results of expert consultation, Self Rating Scale for Self Care Ability of puerperal women included the initial 3 dimensions of self-care attitude, self-care knowledge and self-care skills and 42 items. Conclusions Self Rating Scale for Self Care Ability of puerperal women has high reliability, which can be used as an assessment tool for self nursing ability of puerperal women.

Molecular mechanism for inhibitory effect of puerarin on IL-6 secretion in human osteoblast-like MG-63 cells / 中国药理学通报

Aim To investigate the molecular mecha-nism for the inhibitory effect of puerarin on IL-6 secre-tion in human osteoblast-likeMG-63 cells. Methods According to our previous studies, human osteoblast-like MG-63 cells containing two estrogen receptor ( ER) isoforms are a suitable model for this study. En-zyme-linked immnosorbent assay (ELISA), RT-PCR, luciferase reporter assay and small interfering RNA were performed to investigate the effect of puerarin on IL-6 expression in osteoblast-derived cells and underly-ing molecular mechanism. Results Puerarin could obviously inhibit IL-6 expression and IL-6 promoter ac-tivity by human osteoblastic MG-63 cells. Treatment with the ER antagonist ICI 182,780 abrogates the a-bove actions of puerarin on osteoblast-derived cells. U-sing siRNA technology, we further demonstrated that the effects of puerarin on IL-6 production were media-ted by ERα. Conclusion The effect of puerarin on IL-6 production in osteoblast is mediated by ERα.

The study of resveratrol by modulating SATA3 on acute myeloblastic leukemia / 中国药理学通报

Aim To discuss the pathway of resveratrol for anti-acute myeloblastic leukemia.Methods Human acute myeloblastic leukemia cell Kasumi-1 was applied in this study.After different doses of Res treatment for different time, methyl thiazolyl tetrazolium(MTT)colorimetry was used to detect the cell proliferation.Furthermore, apoptosis and cell cycle were detected by flow cytometry.Western blot and reverse transcription polymerase chain reaction(RT-PCR)were used to detect the expression levels of Bcl-2 and Bax for mRNA and protein.The activity of signal transducers and activators of transcription 3(STAT3)was detected by immunoblotting and Luciferase reporter gene assay.On the other hand, leukemia-bearing mice models were made to investigate the live situation, survival time and the activation of STAT3 by Western blot and immunohistochemical method.Results Resveratrol could suppress the proliferation of Kasumi-1, and induce cell cycle arrest and apoptosis.At the same time, the ratios of Bcl-2/Bax and phosphor-signal transducers and activators of transcription 3(p-STAT3)were decreased significantly.In vivo, resveratrol could prolong the life span of Kasumi-1-bearing mice and attenuate the activity of STAT3 in a dose-dependent manner.Conclusions Resveratrol is a natural occurring chemotherapeutic agent present in Chinese Herbals.The regulatory effect on signaling pathways involved in STAT3 by resveratrol may be associated with its anti-leukemia effect.

Effect of estrogen on experimental autoimmune thyroiditis in Wistar rats / 中华内分泌代谢杂志

Objective To observe the effects of estradiol-17? (E 2-17?) on the induction of experimental autoimmune thyroiditis (EAT). Methods Ten-week old female Wistar rats were ovariectomized (OVX). EAT of Wistar rats was induced by immunization with thyroglobulin (Tg) from SD rats in the presence of complete Freund′s adjuvant. Thyroiditis was pathologically evaluated by HE staining. E 2-17? and PRL levels were measured by RIA, anti-Tg antibody (TgAb) was detected by ELISA, and interferon (IFN)-?, interleukin (IL)-10 mRNA in thyroid were assayed by RT-PCR. Results The serum level of E 2-17? (17.60?1.02)pmol/L and PRL (2.45?0.15)?g/L were much lower in OVX rats than intact rats 〔(58.56?6.99)pmol/L and (3.22?0.17)?g/L, respectively〕 (both P