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Objective To observe the clinical efficacy of different dialysis frequency and methods in the treatment of chronic renal failure uremia patients ,and to provide a reliable reference for clinical practice.Methods From February 2016 to February 2017,140 chronic renal failure uremic patients who admitted to the Department of Nephrology at Taizhou Central Hospital were selected and divided into the observation group and the control group by complete random distribution method ,with 70 cases in each group.The patients in the control group received 3 times of regular hemodialysis treatment per week , while the observation group received 3 times of regular hemodialysis combined with 1 time of hemodiafiltration treatment per week.The clinical treatment effects and complications of the two groups were compared.Results Compared with blood uric acid ( BUA) [(532.09 ±71.05) mmol／L],serum creatinine(Scr) [(734.34 ±63.08) μmol／L],blood urea ( BUN) [(23.84 ±2.58) mmol／L],serum phosphorus [(1.98 ±0.37)mmol／L],parathyroid hormone ( PTH) [(464.37 ±113.92) ng／L],β2 microglobulin ( β2 -MG) [(13.48 ±6.38)mg／L]in the control group,BUA[(495.89 ±58.23) mmol／L],Scr[(684.34 ±77.32)μmol／L], BUN[(20.62 ±1.77) mmol／L],serum phosphorus [(1.74 ±0.44) mmol／L],PTH[(352.14 ±123.25) ng／L], β2 -MG[(9.58 ±5.45) mg／L] were significantly lower in the observation group ,the differences were statistically significant (t＝3.29,4.19,8.61,3.49,5.59,3.88,all P＜0.01).Compared with the incidence rate of pruritus in the control group(61.43%),the incidence rate of pruritus in the observation group (34.29%) was significantly lower (χ2 ＝9.72,P＜0.01),the incidence of other complications had no statistically significant differences ( χ2 ＝1.14, 1.58,3.08,all P＞0.05).Conclusion Hemodialysis 3 times combined with 1 time of hemodiafiltration per week has significant advantage in the treatment of chronic renal failure uremia patients ,which can effectively remove urine toxin molecules and reduce the incidence of complications ,and it is worthy of clinical application.
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Objective@#To observe the clinical efficacy of different dialysis frequency and methods in the treatment of chronic renal failure uremia patients, and to provide a reliable reference for clinical practice.@*Methods@#From February 2016 to February 2017, 140 chronic renal failure uremic patients who admitted to the Department of Nephrology at Taizhou Central Hospital were selected and divided into the observation group and the control group by complete random distribution method, with 70 cases in each group.The patients in the control group received 3 times of regular hemodialysis treatment per week, while the observation group received 3 times of regular hemodialysis combined with 1 time of hemodiafiltration treatment per week.The clinical treatment effects and complications of the two groups were compared.@*Results@#Compared with blood uric acid(BUA)[(532.09±71.05)mmol/L], serum creatinine(Scr)[(734.34±63.08)μmol/L], blood urea(BUN)[(23.84±2.58)mmol/L], serum phosphorus[(1.98±0.37)mmol/L], parathyroid hormone(PTH)[(464.37±113.92)ng/L], β2 microglobulin(β2-MG)[(13.48±6.38)mg/L]in the control group, BUA[(495.89±58.23)mmol/L], Scr[(684.34±77.32)μmol/L], BUN[(20.62±1.77)mmol/L], serum phosphorus[(1.74±0.44)mmol/L], PTH[(352.14±123.25)ng/L], β2-MG[(9.58±5.45)mg/L] were significantly lower in the observation group, the differences were statistically significant (t=3.29, 4.19, 8.61, 3.49, 5.59, 3.88, all P<0.01). Compared with the incidence rate of pruritus in the control group(61.43%), the incidence rate of pruritus in the observation group(34.29%) was significantly lower (χ2=9.72, P<0.01), the incidence of other complications had no statistically significant differences(χ2=1.14, 1.58, 3.08, all P>0.05).@*Conclusion@#Hemodialysis 3 times combined with 1 time of hemodiafiltration per week has significant advantage in the treatment of chronic renal failure uremia patients, which can effectively remove urine toxin molecules and reduce the incidence of complications, and it is worthy of clinical application.
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OBJECTIVE:To preliminarily study the stability of 3 pieces of Chinese medicinal formula(CMF)after decoction, and provide reference for guaranteeing storage quality of decocted liquid and improving safety of drug use. METHODS:3 represen-tative formulas of Gegen Huangqin Huanglian decoction(A formula),Wuling powder(B formula)and Didang decoction(C for-mula)from Shanghan Zabing Lun were selected,the decocted liquid were stored under ambient temperature(25 ℃)and refrigerat-ed temperature (4 ℃) after decocting by automatic boiling-machine and packing. The microorganism,precipitation,pH and con-tents of total flavonoids,alkaloid,polysaccharide,total protein after 1,7,14,21,28 d were detected. RESULTS:Compared with the first day,contents of total flavonoids,polysaccharide in formula A at ambient temperature group were significantly in-creased on the 28th(P<0.05),content of polysaccharide in refrigerated temperature group was significantly increased(P<0.05). Content of polysaccharide in formula B at ambient temperature group was significantly decreased(P<0.05). The pH and content of total flavonoids in formula C at ambient temperature group and refrigerated temperature group were significantly increased (P<0.05 or P<0.01). Other indexes showed no obvious changes during the trial period. CONCLUSIONS:Under ambient temperature and refrigerated temperature,liquid ingredients of above decocted CMF will change when storing for 4 weeks. It indicates that the storage time of decocted CMF should not be more than 3 weeks.