RESUMO
Objective To compare the clinical effects and safety of two kinds of adjuvant chemotherapy in treatment of patients with colon cancer with Ⅱ-Ⅲ stage after radical resection including 5 -FU/CF scheme and FOLFOX4 scheme.Methods 110 patients with colon cancer with Ⅱ-Ⅲ stage after radical resection were chosen from July 2010 to July 2013 in our hospital and were randomly divided into two groups.A group (55 patients) was given 5-FU/CF scheme and B group (55 patients) received FOLFOX4 scheme.The recurrence and metastasis rate with follow-up,survival time and drug side effects incidence were compared between the two groups.Results The recurrence and metastasis rates with follow-up of B group(18.18%,25.45%) were significantly better than A group (34.55%,63.64%)(χ2 =9.12,8.74,all P0.05).Conclusion Compared with 5-FU/CF scheme,FOLFOX4 scheme in treatment of patients with colon cancer withⅡ-Ⅲstage after radical resection can efficiently reduce the risk of recurrence and metastasis,prolong the survival time and not increase the risk and extent of drug adverse effects.