Neuropathologic investigation of area tempestas sclerosis in epileptic sensitive rats / 中国应用生理学杂志

<p><b>AIM AND METHODS</b>The relation between AT sclerosis (loss of neurons and proliferation of astrocytes) and long-lasting epileptic susceptibility was investigated by thionine staining, GFAP immunohistochemistry and observing the behavior of rats, after scorpion venom (SV) or normal saline (NS) administrated for three week.</p><p><b>RESULTS</b>Compared with NS+ NS group, both the loss of neurons and proliferation of astrocytes were very marked in KA+ NS group (epileptic susceptible rats) (P < 0.05), but those changes were not visible in KA+ NS group (epileptic nonsusceptible rats).</p><p><b>CONCLUSIONS</b>It suggested that AT sclerosis may be one of important reasons of the long-lasting epileptic susceptibility.</p>