Expressions of FOSB and P16 and their correlation in different molecular subtypes of breast invasive ductal cancer / 上海交通大学学报（医学版）

Objective: To detect the expressions of proto-oncogene protein FOSB and cyclin protein P16 in the different molecular subtypes of breast invasive ductal cancer and their correlation. Methods: The tumor tissues of 138 patients diagnosed with breast invasive ductal cancer by postoperative pathological examinations in Zhongshan Bo'ai Hospital from August 2013 to March 2019 were collected with normal breast tissues as control. Immunohistochemical staining was performed for the expressions of FOSB and P16 to investigate their correlation in the breast cancer. Besides, their expressions and their correlations in the different molecular subtypes of breast cancers, i.e. Luminal A, Luminal B [According to the expression of human epidermal growth factor 2 (HER2), it can be divided into HER2- and HER2+.], HER2 positive subtype, and triple-negative breast cancer (TNBC), were also detected. Results: ① The expression level of FOSB in 138 cases of breast invasive ductal cancer tissues was negatively correlated with P16 (r= -0.181, P=0.033). ② The expression of FOSB was significantly higher in Luminal A than those in other subtypes (P=0.028, P=0.033, P=0.001, P=0.010), while the expression of P16 was significantly higher in TBNC than those in other subtypes (P=0.025, P=0.005, P=0.008, P=0.011). ③ The expression level of FOSB in TBNC was negatively correlated with the expression of P16 (r=-0.566, P=0.018). Conclusion: The expressions of FOSB and P16 in the different molecular subtypes of breast invasive ductal cancer are different. The expression level of FOSB significantly increases in Luminal A, and that of P16 significantly increases in TBNC. There is a negative correlation between the expression levels of FOSB and P16 in TBNC.

Relation among Ultrasound Findings，Clinical Significance and Expression of FosB in Invasive Breast Cancer / 中山大学学报(医学科学版)

@#【Objective】To investigate the expression of FosB in invasive breast cancer and its correlation to the ultrasound findings and clinical significance.【Methods】Immunohistochemical and ultrasound examination were performed for 155 cases with invasive breast cancer，36 cases with paracancerous tissue and 30 cases with normal breast tissue. To investigate the correlations between the different expression of FosB with histological grade ，lymph nodes，and ultrasound findings.【Results】①The expression of FosB in paracancerous tissue and normal breast tissue was higher than that in invasive breast cancer（P＜0.01）. ②Based on immunohistochemical staining，high positive expression rate of FosB was associated with low histological grade，ER positive and PR positive（P＜0.05）. There was no correlation between FosB and age，tumor diameter，lymph nodes，Her2 and clinical stages（P＞0.05）③The expression of FosB was higher in microcalcification positive and lymph nodes bigger tissues（P＜0.05）. There was no correlation between FosB and tumor size， regular shape，boundary，posterior attenuation ratio and blood flow（P＞0.05）.【Conclusion】The expression of FosB in invasive breast cancer was lower than that in paracancerous tissue and normal breast tissue. The different expression of FosB was correlated with histological grade，ER positive and PR positive. To study the expression of FosB in invasive breast cancer may be helpful for differential diagnosis and targeted treatment. The different expression of FosB was correlated with microcalcification，lymph nodes，and combined FosB with ultrasound findings may contribute to prognostic evaluation of breast cancer.

ExpressionandClinicalSignificanceofJunDinMolecularSubtypesof InvasiveBreastCarcinoma / 中山大学学报(医学科学版)

@#【Objective】ToinvestigatetheexpressionandclinicalsignificanceofJunDinmolecularsubtypesofinva⁃ sivebreastcarcinoma，benignandmalignantbreastlesions.【Methods】Immunohistochemicalexaminationwasperformed for160patientswithinvasivebreastcarcinoma，191patientswithbreastintraductalproliferativelesionsand20patients withnormalbreasttissue.【Results】①ComparisonwithothersubtypesshowedthattheexpressionofJunDwassignificantly increasedinTBNCsubtype（P＜0.05）anddifferencesbetweenothersubtypeswerenotstatisticallysignificant（P＞0.05） . ②TheexpressionofJunDininvasivebreastcarcinomawaslowerthanthatinbreastintraductalproliferativelesionsand normalbreasttissuse（P <0.01） .③Basedonimmunohistochemicalstaining，highpositiveexpressionrateofJunDwas associatedwithlowhistologicalgrade（P <0.01）.ThereisnocorrelationbetweenJunDandtumordiameter，age，lymph nodes，ER，PRandhistologicalgrade（P >0.05） .【Conclusions】TheexpressionofJunDwassignificantlyincreasedin TBNCsubtype.TostudytheexpressionofJunDinTBNCsubtypeofinvasivebreastcarcinomamayprovideanevaluation intargetedtreatment.ThedifferentexpressionofJunDinbenignandmalignantbreastlesionsmaybehelpfulfortheir differentialdiagnosis.