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BACKGROUND:Bone tissue engineering is the most promising way to treat bone defects at present. The key problem is to construct vascular networks which can provide oxygen and nutrients for new bone, and thereby provide a way for the body metabolism. OBJECTIVE:To review the characteristics of bone tissue engineering scaffold materials and to introduce the development of composite scaffold materials. METHODS:With the key words of“bone tissue engineering, scaffold, vascularization, composite scaffold”in Chinese and in English, respectively, a computer-based search was performed for articles published in CNKI and PubMed databases from January 2001 to January 2014. After the initial screening, the reserved articles were further detailed, summarized and concluded. RESULTS AND CONCLUSION:According to the different sources, the bone tissue engineering scaffold materials can be divided into artificial materials, natural derivatives and composite scaffold materials. Single scaffold is difficult to be the most ideal material for repair of bone defects, while composite scaffold can make up for the defects of the single scaffold to different degrees. Therefore, in recent years, the bone tissue engineering scaffolds have developed from single to composite scaffolds and there is the trend of organic combination of artificial materials and natural derivatives. However, composite scaffolds have many problems to be solved in the clinical application. The main aspect is to control the proportion of the composite scaffold so that the degradation of materials can be matched with growth of tissues and cells. The other one is to keep the porous and high mechanical strength of the composite scaffold.
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OBJECTIVE: To discuss about the meaning of short-range application of gynecological perioperative antibacterials and its efficacy of infection prevention. METHODS: 100 cases of type Ⅰ & Ⅱ incision selective operations during Jun.～Nov., 2006 (control group) and 105 cases during Jun.～Nov., 2007 (short-range group) were collected and analyzed in respect of hospitalization time, hospitalization time after operation, applying time of antibacterials, cost of antibacterials, variety of antibacterials and post-operation infection. RESULTS: In short-rang group costs and applying time of antibacterials reduced significantly, which were significantly different from that in control group. No significant difference was noted in cases of post-operation infection. CONCLUSION: There is no significant difference between short-range medication and long-range medication for preventing infection of gynecological type Ⅰ & Ⅱ incision selective operation.