Research advances in familial exudative vitreoretinopathy / 国际眼科杂志(Guoji Yanke Zazhi)

·Familial exudative vitreoretinopathy ( FEVR ) is a hereditary disease associated with abnormal angiogenesis in the pediatric period. The most prominent finding of the disease is avascularity in the peripheral retina. Whereas, the phenotypic features are variable. In some minor cases, missed diagnosis would happened due to asymptom, while, in severe FEVR, neovascularization, retinal exudation, retinal folds, macular heterotopy and retinal detachment may occur and give rise to extremely poor vision or even blindness. Mutations in the FZD4, LRP5, NDP, TSPAN12, ZNF408, and KIF11 genes have been reported to contribute to FEVR with X - linked recessive, autosomal dominant, and autosomal recessive inheritance manners. We have summarized aspects of pathogenesis, clinical features and classification, mutations genes as well as diagnosis and treatment of FEVR in this review.

Development of surgery for proliferative diabetic retinopathy / 国际眼科杂志(Guoji Yanke Zazhi)

Given the poor prognosis of proliferative diabetic retinopathy (PDR),the morbidity of PDR has also increased recent years.Modern surgery has undergone a very impressive development over the last 10a due to the evolution of methods,techniques and extension of surgical indications.In this article,we will review the current choices of the surgery time,perioperative managements,as well as the methods of the vitrectomy.